Bronchopulmonary Dysplasia

Hospitalizations for respiratory syncytial virus bronchioliti

Pediatr Pulmonol

OBJECTIVE: To determine if nasal high-frequency percussive ventilation (nHFPV) to manage neonatal respiratory distress decreases the regional cerebral oxygen saturation (rScO(2) ) compared to nasal CPAP. STUDY DESIGN: A prospective, randomized, monocentric, open-label, non-inferiority crossover trial. Newborns of gestational age (GA) ≥ 33 weeks exhibiting persistent respiratory distress after 10 min of life were treated with nHFPV and nCPAP, in succession and in random order. The primary endpoint was the mean rScO(2) , as revealed by near-infrared spectroscopy (NIRS). RESULTS: Forty-nine newborns were randomized; the mean GA and birth weight were 36.4 ± 1.9 weeks and 2,718 ± 497 g. The mean rScO(2) difference during the last 5 min of each ventilation mode (nHFPV minus nCPAP) was -0.7 ± 5.4% (95% CI -2.25; 0.95%). CONCLUSION: In our study on newborns of GA ≥ 33 weeks treated for respiratory distress, cerebral oxygenation via nHFPV was not inferior to nCPAP. This article is protected by copyright. All rights reserved

Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

International audienceno abstrac

Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at <33 weeks gestation without bronchopulmonary dysplasia: the CASTOR study

International audienceThis study was conducted during the 2008-2009 respiratory syncytial virus (RSV) season in France to compare hospitalization rates for bronchiolitis (RSV-confirmed and all types) between very preterm infants (\textless33 weeks' gestational age, WGA) without bronchopulmonary dysplasia and full-term infants (39-41 WGA) matched for date of birth, gender and birth location, and to evaluate the country-specific risk factors for bronchiolitis hospitalization. Data on hospitalizations were collected both retrospectively and prospectively for 498 matched infants (249 per group) aged \textless6 months at the beginning of the RSV season. Compared to full-term infants, preterm infants had a fourfold [95% confidence interval (CI) 1·36-11·80] and a sevenfold (95% CI 2·79-17·57) higher risk of being hospitalized for bronchiolitis, RSV-confirmed and all types, respectively. Prematurity was the only factor that significantly increased the risk of being hospitalized for bronchiolitis. The risk of multiple hospitalizations for bronchiolitis in the same infant significantly increased with male gender and the presence of siblings aged ⩾2 years

Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

International audienceno abstrac