2,542 research outputs found

    WS11.4 Host response to Pseudomonas aeruginosa adaptation during airway chronic infection

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    Excitons and charged excitons in semiconductor quantum wells

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    A variational calculation of the ground-state energy of neutral excitons and of positively and negatively charged excitons (trions) confined in a single-quantum well is presented. We study the dependence of the correlation energy and of the binding energy on the well width and on the hole mass. The conditional probability distribution for positively and negatively charged excitons is obtained, providing information on the correlation and the charge distribution in the system. A comparison is made with available experimental data on trion binding energies in GaAs-, ZnSe-, and CdTe-based quantum well structures, which indicates that trions become localized with decreasing quantum well width.Comment: 9 pages, 11 figure

    Scintillation/dynamics of the signal

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    Conformal invariance and its breaking in a stochastic model of a fluctuating interface

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    Using Monte-Carlo simulations on large lattices, we study the effects of changing the parameter uu (the ratio of the adsorption and desorption rates) of the raise and peel model. This is a nonlocal stochastic model of a fluctuating interface. We show that for 0<u<10<u<1 the system is massive, for u=1u=1 it is massless and conformal invariant. For u>1u>1 the conformal invariance is broken. The system is in a scale invariant but not conformal invariant phase. As far as we know it is the first example of a system which shows such a behavior. Moreover in the broken phase, the critical exponents vary continuously with the parameter uu. This stays true also for the critical exponent τ\tau which characterizes the probability distribution function of avalanches (the critical exponent DD staying unchanged).Comment: 22 pages and 20 figure

    Spacecraft thermal control design data

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    This paper shows the actual state of a compilation work on Thermal Control Design Data being done at Madrid (Lamf-ETSIA) under several ESTEC contracts, introducing a Handbook already issued, its additions and updatings

    LandTrendr smoothed spectral profiles enhance woody encroachment monitoring

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    Secondary succession (SS) is one of the main consequences of the abandonment of agricultural and forestry practices in rural areas, causing -among other processes- woody encroachment on former pastures and croplands. In this study we model and monitor the spatial evolution of SS over semi-natural grassland communities in the mountain range of the Pyrenees in Spain, during the last 36 years (1984-2019). Independent variables for ‘annual-based’ and ‘period-based’ modeling were drawn from a suite of Surface Reflectance Landsat images, LandTrendr (LT)-algorithm-adjusted images and LT outputs. Support vector machine (SVM) classifiers were trained and tested using all possible variable combinations of all the aforementioned datasets. The best modeling strategy involved yearly time series of LT-adjusted Tasseled Cap Brightness (TCB) and Wetness (TCW) axes as predictors, attaining a F1-score of 0.85, a Matthew Correlation Coefficient (MCC) of 0.67 and an AUC 0.83. Woodlands encroached above 480, 000 ha of grasslands and crops during the study period. A model using LT outputs for the whole period also denoted good performance (F1-score = 0.85, MCC = 0.75) and estimated a similar area of woodland expansion (~509, 000 ha), but this ‘period’ approach was unable to provide temporal information on the year or the encroachment dynamics. Our results suggest an overall proportion of 66% for the Pyrenees being affected by SS, with higher intensity in the west-central part, decreasing towards the eastern end. © 2021 The Author

    Correlates of species richness in the largest Neotropical amphibian radiation

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    Although tropical environments are often considered biodiversity hotspots, it is precisely in such environments where least is known about the factors that drive species richness. Here, we use phylogenetic comparative analyses to study correlates of species richness for the largest Neotropical amphibian radiation: New World direct-developing frogs. Clade-age and species richness were nonsignficantly, negatively correlated, suggesting that clade age alone does not explain among-clade variation in species richness. A combination of ecological and morphological traits explained 65% of the variance in species richness. A more vascularized ventral skin, the ability to colonize high-altitude ranges, encompassing a large variety of vegetation types, correlated significantly with species richness, whereas larger body size was marginally correlated with species richness. Hence, whereas high-altitude ranges play a role in shaping clade diversity in the Neotropics, intrinsic factors, such as skin structures and possibly body size, might ultimately determine which clades are more speciose than others

    Translational and transdisciplinary approach to the human papilloma virus – Preliminary evidence from the Italian “HPV board: a future without papilloma virus” project

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    Human papillomavirus (HPV) is considered to be one of the viral infections associated with cancers and other diseases. HPV is detected asymptomatically in the oral mucosa. The presence of human papillomavirus in the oral mucosa appears to be closely associated with a series of benign and malign oral lesions. The aim of this paper is to report the Italian experience in applying translational protocols, using new technologies and multidisciplinary strategies in Human Papilloma virus detection and treatment. The “HPV board: a future without papilloma virus” project was born, promoted by CNEL (Italian Council of Economics and Labor) with the collaboration of numerous scientific societies to commonly approach to public knowledge of HPV-related oral lesions and their clinical management. The preliminary results are related to the assessment of the proof-of-concept of this new project. More in details, “HPV Board” is a project that plans the presence of a working group, made up of otolaryngologists, dentists, oral and maxillofacial surgeons, in close contact with gynecologists, oncologists and pediatricians; this working group manages to combine very transversal skills, in order to promote primary prevention projects, early diagnosis and adequate therapies. The “HPV BOARD” project will give the opportunity to increase the attention of patients and doctors on the early diagnosis of oncological diseases dependent on infection by the infectious agent HPV. In this panorama, dentists will have the role of “first sentinel” of public health because oral health is an indicator, too often overlooked, for the prevention of numerous diseases

    Peri-operative red blood cell transfusion in neonates and infants: NEonate and children audiT of anaesthesia pRactice IN Europe: A prospective European multicentre observational study.

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    BACKGROUND Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN A multicentre observational study. SETTING The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION ClinicalTrials.gov, identifier: NCT02350348
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