51 research outputs found
Optical frequency measurement of the 1S-3S two-photon transition in hydrogen
This article reports the first optical frequency measurement of the
transition in hydrogen. The excitation of this
transition occurs at a wavelength of 205 nm which is obtained with two
frequency doubling stages of a titanium sapphire laser at 820 nm. Its frequency
is measured with an optical frequency comb. The second-order Doppler effect is
evaluated from the observation of the motional Stark effect due to a transverse
magnetic field perpendicular to the atomic beam. The measured value of the
frequency splitting is with a relative uncertainty of
. After the measurement of the
frequency, this result is the most precise of the optical frequencies in
hydrogen
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015
Experimental analysis of the whispering-gallery modes in a cylindrical optical microcavity
Evolution des polyosides non cellulosiques au cours du metabolisme anaerobie de la baie de raisin.
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La vinification avec chauffage de la vendange. Resultats de 10 annees d'experimentation
150 ref. 33 tables 15 graph. INRA, Groupe de travail "Chauffage de la vendange" et ENSA de Montpellier*INRA, Paris Diffusion du document : INRA, ParisNational audienc
Action de la caseine sur les composes phenoliques de vins blancs et roses
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Action de la caseine sur les composes phenoliques de vins blancs et roses
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Utilisation d'une anthocyane marquee pour etudier le devenir de la matiere colorante rouge du vin au cours de sa maturation et de son vieillissement.
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Relations entre le degre d'integrite des baies de raisin et leur metabolisme anaerobie.
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