Influence of physical exercise practice against SARS-CoV-2 (COVID-19) infection: narrative review

As a protective measure against the Covid-19 virus, the world health organization strongly recommended social isolation. Because of a lower offer of physical exercise, there was an increase in the number of physical inactivity, poor diet, and psychological disorders. In this sense, this literature review aims to address how the practice of physical exercise is important to protect the metabolic and psychological health of the population. During forced isolation, it was possible to observe an increase in sedentary lifestyle and poor diet. As an outcome, possible damage to the population's mental health was also identified. In contrast, it was observed that individuals who practiced physical exercise, managed to mitigate both metabolic and psychological damage. Ahead, it was also possible to observe that this practice significantly contributed to the individuals' immune system, which can collaborate with the organism in the fight against possible contamination. Given this, the objective of this review was to identify possible implications of physical exercise on psychological and immunological aspects in coping with Covid-19. Important physiological effects of exercise were found, such as elevation of the brain-derived neurotrophic factor (BDNF), which has beneficial effects in controlling depression and cognitive performance; the control of obesity through specific training methodologies can collaborate to control pro-inflammatory cytokines and increase mitochondrial function and immune system. In addition, there are up to 205 symptoms after infection by SARS-CoV2 and physical exercise can be a great ally for recovery. Therefore, it is believed that regular exercise has positive effects before, over, and post-pandemic

Inability of 7,8 – Dihydroxy-4- Methylcoumarin antioxidant activity, to prolong longevity and to protect against stress in Caenorhabditis Elegans worms

Despite an increase in life expectancy, it is known that this factor is not necessarily accompanied by a better quality of life, which reflects in longevity. Aspects related to metabolic stress to which cells are subjected can modulate this process, which can lead to various pathologies. Coumarins are secondary metabolites found in several plants, such as guaco, and are part of the polyphenol family capable of producing up to 1300 derivatives, with potential effects against metabolic stress, in addition to being used in the cosmetics industry with the objective of improving fragrance of products. Therefore, it seems necessary to seek to elucidate molecular mechanisms that can regulate this aging process, which can be associated with the gradual loss of physiological functions of cells and tissues, increasing the number of cells in senescence that may be related to increased oxidative stress. PURPOSE: the aim of this study was to identify the influence of the use of the coumarin synthetic compound 7,8-Dihydroxy-4-methylcoumarin (DHMC) on longevity and resistance to different types of stress in vivo. METHODS: free radical scavenging (DPPH) analyzes were performed for the compound, longevity, and stress tests (H2O2, NaCl, Heat) for C. elegans worms. RESULTS: in the first analysis, the compound showed 92% of antioxidant activity already in small concentrations (25ug/ml) through DPPH analysis. In the following tests DHMC did not show antibacterial responses against Escherichia coli, and Caenorhabditis elegans worms did not show stress reduction or significant improvement in longevity with the use of the compound. CONCLUSION: therefore, the DHMC compound expresses a high antioxidant activity and presents several study potentials. However, it has no biological effects in protecting against stress or contributing to longevity in C. elegans worm

Splenectomy in non-traumatic diseases

Splenectomy represents the first choice for treatment of spontaneous splenic rupture, abscesses, cysts, tumours, and an alternative for control of hereditary, autoimmune, and myeloproliferative disorders. However, its relative indications have been reviewed for better understanding of both the primary affections and of splenectomy per se, particularly with regard to the immune system. The emergence of minimally invasive surgery, the possibility of splenic preservation, and availability of biological therapy has shown that the procedure has often been referred to as salvage therapy upon failure of other therapeutic propositions. On the other hand, patients have their general health status compromised by the underlying disease, by the use corticosteroids or biologic therapy, immunosuppressed, coagulation disorders, which contribute to the incidence of postoperative complications, such as infections, bleeding and venous thrombosis. Therefore, this scenario favours higher morbidity and mortality rates than those of other intra-abdominal surgical procedures. Thus, this review has the primary and comprehensive objective of purpose the best moment for splenectomy, when surgeons can interfere in the natural course of the disease increasing patients’ quality of life and survival. In short, it is desired that the surgeon has complete knowledge of the profound physiological changes imposed on the host. In addition, to distinguish when it is curative and mandatory from when it must be put on hold due to other non-operative treatments with similar outcomes and, lastly, when it is not recommended for not aggregating survival

ISOMORFISMO NORMATIVO: influência das instituições na construção do perfil do Administrador

O objetivo deste artigo é analisar o processo de institucionalização do perfil do administrador a partir do isomorfismo normativo, observado principalmente na adoção de políticas de profissionalização. Na primeira parte, é feita uma revisão na literatura sobre a Teoria Institucional e uma reflexão dos debates dos seus principais autores. Analisa-se as influências estrangeiras na construção do modelo “brasileiro” de administração e o papel das instituições na concepção do perfil do administrador brasileiro. Na segunda parte, são analisadas três entrevistas de executivos, retiradas de um jornal online com a finalidade de verificar como o processo de isomorfismo normativo se dá por meio das organizações. E por fim, os resultados sugerem um comportamento de homogeneização no perfil do administrador, que parece ser recorrente em diferentes organizações e se mantém como mecanismo de legitimação no campo organizacional.   This paper aims to analyze the process of institutionalization of the administrator’s profile in the process of normative isomorphism, observed mainly in the adoption of professionalization policies. In the first part, there is a literature review of the Institutional Theory and a reflection on the debates of its main authors. The foreign influences are analyzed in the construction of the "Brazilian" model of management and the role of institutions in the design of the brazilian administrator’s profile. In the second part, three interviews of CEO’s were taken from an online newspaper and analyzed with a purpose to verificate how the process of normative isomorphism happens through the organizations. Finally, the results point to a homogenization behavior in the administrator’s profile, which is recurrent in different organizations and remains a mechanism of legitimacy in the organizational field

Public Policies for Renewable Energy: A Review of the Perspectives for a Circular Economy

The development and implementation of public policies towards renewable energies are crucial in order to address the contemporary challenges faced by humanity. The 3Rs (reduce, reuse, and recycle), as a circular economic practice, are often cited as one of the best solutions for sustainable development. Therefore, this study analyzed public policies for renewable energy from the perspective of the circular economy. Accordingly, a systematic review of the literature was carried out with respect to the beneficiaries and convergences of circularities, with a focus on public policies for renewable energies. The sample had public policies classified into three types (distributive, redistributive, and regulatory policies). The results showed that the first studies began in 1999, with a significant increase in publications during the 2010s, in which Germany was the country with the greatest contribution. The analyses associated with space showed the countries committed to the use of renewable energies and the 3Rs of the circular economy to reduce greenhouse gas emissions. The economic analyses revealed that the circular economy for the generation of renewable energy has a positive economic return in terms of social well-being and the mitigation of environmental degradation. There is a barrier to the circular economy’s development posed by the cost of its implementation in the private sector and the resistance to raising awareness in society, requiring strong public sector engagement in decision making and the constant evaluation of public policies. It is concluded that the circular economy facilitates more efficient, productive structures and public policies, promoting alternatives for energy security and sustainability for the world energy matrix

Systematic Literature Review on Virtual Electronics Laboratories in Education: Identifying the Need for an Aeronautical Radar Simulator

The objective of this work is to propose the development of a virtual electronics laboratory with an aeronautical radar simulator using immersive technologies to help students learn. To verify whether this proposal was viable, the systematic literature review (SLR) methodology was used, whose objective was to verify whether immersive technologies were being used effectively in education and, also, what challenges, opportunities, and benefits they bring to Education 4.0. For this, eight Research Questions (RQs) were formulated to be answered by articles based on the highest SLR scores. The results presented by SLR were as follows: there was an increase in the use of immersive technologies in education, but virtual reality (VR) is still more used in education than AR, despite VR being more expensive than AR; the use of these new technologies brings new challenges, opportunities, and benefits for education; there was an increase in the quality of teaching for complex subjects; and there was an increase in students’ interest in the content presented

Insertion sequences disrupting mgrB in carbapenem-resistant Klebsiella pneumoniae strains in Brazil

Objectives: This study aimed to characterise insertional mutations disturbing themgrB gene in carbapenem-resistant Klebsiella pneumoniae (CRKp). Methods: A total of 118 clinical CRKp isolates were surveyed for polymyxin resistance and insertion sequence (IS) elements disruptingmgrB. Results: Of the 118 isolates, 78 (66.1%) displayed polymyxin resistance, of which 54% (42/78) hadmgrB::IS inserts. Sequencing analyses showed 13 insertion sites in mgrB. mgrB::ISSen4(IS3) was observed for the first time in CRKp. Conclusions: Ten different IS elements disruptedmgrB, with a predominance (76%) of IS5 sequences

PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ± 3.6%, indicating the severity of the insult. PhTx3-4 treatment increased the amplitude of the b-wave, which was almost equivalent to the control retinas that were not submitted to injury. The PhTx3-4 functional protection of the retinas recorded on the ERG also was observed in the neuroprotection of retinal cells. NMDA-induced injury reduced live cells in the retina layers and the highest reduction, 84%, was in the ganglion cell layer. Notably, PhTx3-4 treatment caused a remarkable reduction of dead cells in the retina layers, and the highest neuroprotective effect was in the ganglion cells layer. NMDA-induced cytotoxicity of the retina increased the release of glutamate, reactive oxygen species (ROS) production and oxidative stress. PhTx3-4 treatment reduced glutamate release, ROS production and oxidative stress measured by malondialdehyde. Thus, we presented for the first time evidence of in vivo neuroprotection from NMDA-induced retinal injury by PhTx3-4 (-ctenitoxin-Pn3a), a spider toxin that blocks N-P/Q calcium channels

7-Chloroquinolinotriazoles : synthesis by the azide-alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies.

Twenty-seven 7-chloroquinolinotriazole derivatives with different substituents in the triazole moiety were synthesized via copper-catalyzed cycloaddition (CuAAC) click chemistry between 4-azido-7- chloroquinoline and several alkynes. All the synthetic compounds were evaluated for their in vitro activity against Plasmodium falciparum (W2) and cytotoxicity to Hep G2A16 cells. All the products disclosed low cytotoxicity (CC50 > 100 mM) and five of them have shown moderate antimalarial activity (IC50 from 9.6 to 40.9 mM). As chloroquine analogs it was expected that these compounds might inhibit the heme polymerization and SAR studies were performed aiming to explain their antimalarial profile. New structural variations can be designed on the basis of the results obtained