Evaluation of metabolic changes in liver and serum of streptozotocininduced diabetic rats after Mango diet supplementation

Mango consumption has shown bioactive properties against several diseases like diabetes, therefore, we evaluated how a mango-supplemented diet affects metabolic pathways in diabetic rats. Serum and liver samples were collected from 26 rats divided into 3 groups (healthy, untreated diabetic and mango-treated diabetic) after dietary intervention and analysed using an LC-MS untargeted metabolomic strategy. Twenty-six and 29 metabolites in serum and liver were potentially annotated, showing significant differences among groups. Several affected pathways were due to the disease state [fatty acids (i.e. palmitoleic, linolenic, stearidonic, eicosapentaenoic, docosahexaenoic acids and others), bile acids (i.e. glycocholic acid) and amino acids (i.e. leucine, isoleucine and valine)], and others due to mango supplementation (increased hepatic bioaccumulation of euxanthone, a mangiferin metabolite, and increased glutathione concentration). These results suggest that a mango-supplemented diet exerted a significant antioxidant effect in the liver of diabetic rats, likely due to its phenolic compounds, like mangiferin and its metabolites.The author AFO received support from the Spanish Ministry of Education, Culture and Sports (FPU grant 14/03992). RCC is thankful to CIAD-CONACYT for the scholarship received. We thank CONACYTMexico for financial support of the project Ciencia de la Frontera (P00054044). This study is considered as part of the collaboration that ASC and GAG have in the network (ALSUB-CYTED, 118RT0543)

The new metropolitan voices: glossary of metropolitan terms

Metropolitan Glossary is one of the fundamentals of the TELLme project. Together with the Metropolitan Existing Situation Analysis (MESA), and General Issues and Principles (MGIP) it makes the basis of building the complexity of Metropolitan Discipline. need of a glossary for the metropolitan discipline emerged from the long experiences of the HEI partners working in the multidisciplinary environment of metropolitan context. A clear set of definition describing various concepts of the new subject is fundamental for easy communication not only amongst the different fields in the academy but also with the practitioners. Every sector has its own terminologies defined within the circle and there is a limit in using the terms without reaching an agreement on the meanings of the vocabulary used in the discussion. However, multidisciplinary approach does not require individuals to be professional in all required fields; It rather needs various professionals to understand that priorities are set different when coming from a different discipline. While encouraged to think out of their own box, it is important to have some inside views in other boxes to reach a holistic conclusion. Glossary serves as the basis in understanding the different perspectives from various fields and topics.Fil: Reyes Rodriguez, Ramón. Universidad de Guadalajara; MéxicoFil: Contin, Antonella. Politecnico di Milano; ItaliaFil: Giordano, Patricia. Politecnico di Milano; ItaliaFil: Alcantara Onofre, Saúl. Universidad Autonoma Metropolitana. Unidad Xochimilco.; MéxicoFil: Becerra Mercado, Olga Clarisa. Universidad de Guadalajara; MéxicoFil: Camacho Garcia, Socorro. Universidad de Guadalajara; MéxicoFil: Castro Lopez, Jose. Universidad Autonoma Metropolitana. Unidad Xochimilco.; MéxicoFil: Espino Hidalgo, Blanca del. Universidad de Sevilla; EspañaFil: Galiulo, Valentina. Politecnico di Milano; ItaliaFil: Giordano, Patrizia. Politecnico di Milano; ItaliaFil: Lanfranchi, Gabriel. Centro de Implementación de Políticas Públicas para la Equidad y el Crecimiento; ArgentinaFil: Lepratti, Massimiliano. Politecnico di Milano; ItaliaFil: Marchionni, Franco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Marinsalda Pastor, Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales. Centro de Estudios de Innovación Institucional para la Gobernabilidad Democrática; ArgentinaFil: Márquez Rizo, Rubén. Universidad de Guadalajara; MéxicoFil: Mascort Albea, Emilio José. Universidad de Guadalajara; MéxicoFil: Ocejo Cázares, María Teresa. Universidad Autónoma Metropolitana; MéxicoFil: Pastor, Gabriela Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Reyes Rodríguez, Eliazar. Universidad de Guadalajara; MéxicoFil: Sánchez Fuentes, Domingo. Universidad de Sevilla; EspañaFil: Sanna, Stefano. Politecnico di Milano; ItaliaFil: Tapia Martín, Carlos. Universidad de Sevilla; EspañaFil: Torres, Laura María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Žižek, Andrej. Doba Business School; Cha