Representaciones sociales del concepto y del proceso de adopción en parejas sin hijos con posibilidad de adoptar

The objective of this study was to explore the social representations of the concept and the adoption process in couples without children with the possibility of adopting, using a qualitative approach of descriptive type. The informative unit of the study was made up of 50 couples in total with the possibility of adopting, whose average age was 34 years, people from different social and cultural contexts were taken as reference, among these characteristics are the level of education, marital status, the socioeconomic stratum and religious inclination. Participants were selected by representative sampling for convenience. The results obtained were analyzed with the axial model through the ATLAS.ti 8 software, which yielded the following results: First, it was found that the negative implications about the adoption process are cause of the legal aspects of adoption. Second, the misperception about the adoption process is a cause of ignorance regarding the adoption process. Third, the biological implications of the adoption process are associated with adoption as a possibility of family structuring. Finally, the concept of adoption seen from the perspective of the vulnerability of the child is associated with the perspective of adoption from abandonmentEste estudio tuvo como objetivo explorar las representaciones sociales del concepto y del proceso de adopción en parejas sin hijos con posibilidad de adoptar, empleando un enfoque cualitativo de tipo descriptivo, la unidad informativa del estudio fue conformada por un total de 50 parejas con posibilidad de adoptar, cuya edad promedio fue de 34 años, en donde se tomó como referencia personas de diferentes contextos sociales y culturales, entre estas características se encuentran el nivel de escolaridad, el estado civil , su estrato socioeconómico y su inclinación religiosa. Los participantes fueron seleccionados mediante un muestreo representativo por conveniencia. Los resultados obtenidos fueron analizados con el modelo axial a través del software ATLAS.ti 8, los cuales arrojaron los siguientes resultados; en un primer momento se encontró que las implicaciones negativas acerca del proceso de adopción son causa de los aspectos legales de la adopción. En segunda instancia la percepción errónea acerca del proceso de adopción es causa del desconocimiento frente al proceso de adopción. En tercer lugar, están que las implicaciones biológicas frente al proceso de adopción están asociadas con la adopción vista como posibilidad de estructuración familiar; Finalmente, el concepto de adopción visto desde la vulnerabilidad del niño está asociado con la perspectiva de la adopción desde el abandon

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality