Medical Practices and Attitudes of Dual-Licensed Medical Doctors in Korea

Unique dual medical system in Korea has resulted in the emergence of dual-licensed medical doctors (DLMDs) who have both traditional Korean medicine (KM) and Western medicine (WM) licenses. There have been few studies on DLMDs in spite of their growing number and importance within the medical system. We surveyed the current status and attitudes of DLMD to assess their role in integrative medicine. Questionnaires were administered to the members of the association of DLMD. Data from 103 DLMD were collected and statistically analyzed. 41.4% of DLMD were copracticing both WM and KM at a single clinic, preferring the WM approach for physical examinations, laboratory tests, and education for patients—and the KM approach for treatment and prescription. Musculoskeletal, gastroenterologic, and allergic diseases were considered to be effectively treated with co-practice. DLMD highly agreed on the efficiency of copractice for disease control and patients’ satisfaction. On the other hand, they regarded the lack of health insurance coverage for copractice and increased medical expenditure as major problems in providing co-practice. To expand the role of DLMD as mediators of integration in primary health care, the effectiveness of their co-practice should be evaluated and a corresponding health insurance reimbursement system should be established

Offset responses in primary auditory cortex are enhanced after notched noise stimulation

Notched noise (white noise with embedded spectral gap) causes significant excitatory offset responses in the auditory cortex of awake and anesthetized guinea pigs. The largest offset responses were located in the infragranular/granular layers, and current source density analysis revealed that offset responses were associated with an early current sink localized in the upper infragranular layers. We discuss the possibility that the offset responses might be associated with an auditory phantom percept (Zwicker tone)

Strong hole-doping and robust resistance-decrease in proton-irradiated graphene

Great effort has been devoted in recent years to improve the electrical conductivity of graphene for use in practical applications. Here, we demonstrate the hole carrier density of CVD graphene on a SiO2/Si substrate increases by more than one order of magnitude to n = 3 x 10(13) cm(-2) after irradiation with a high energy 5 MeV proton beam. As a result, the dc-resistance (R) of graphene is reduced significantly by 60%. Only a negligible amount of defect is created by the irradiation. Also the hole-doped low resistance state of graphene remains robust against external perturbations. This carrier doping is achieved without requiring the bias-gate voltage as is the case for other field effect devices. We make two important observations, (i) occurrence of the doping after the irradiation is turned off (ii) indispensability of the SiO2-layer in the substrate, which leads to a purely electronic mechanism for the doping where electron-hole pair creation and interlayer Coulomb attraction play a major role. A flux-dependent study predicts that an ultrahigh doping may be obtained by longer irradiation. We expect the irradiation doping method could be applied to other atomically thin solids, facilitating the fundamental study and application of the 2d materials

hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Dbp mRNA) Oscillation To Sustain Circadian Rhythms

Circadian gene expression is defined by the gene-specific phase and amplitude of daily oscillations in mRNA and protein levels. D site-binding protein mRNA (Dbp mRNA) shows high-amplitude oscillation; however, the underlying mechanism remains elusive. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter. Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro. Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Finally, knockdown of hnRNP K decreased mRNA oscillation in both Dbp and Dbp-dependent clock genes. Taken together, our results show rhythmic protein expression of hnRNP K and provide new insights into its function as a transcriptional amplifier of Dbp

Preconceptual Design of Multifunctional Gas-Cooled Cartridge Loop for the Versatile Test Reactor—Part I

An integrated effort by the Versatile Test Reactor (VTR) Gas-Cooled Fast Reactor (GFR) Team to develop an experiment vehicle or extended-length test assembly for the VTR experiments is led by the Idaho National Laboratory and supported by an industrial partner, General Atomics, and university partners, including Texas A&M University, University of Michigan, Oregon State University, University of Houston, and University of Idaho. The overall focus of the effort is to design a helium gas-cooled cartridge loop (GCL) to assist with the testing of fuels, materials, and instrumentation to further support development of advanced reactor systems. This study is divided into two parts. Part I provides the GCL functional requirements and critical irradiation data needs for advancing GFR technologies. Part II includes the measurement techniques developed to measure the thermophysical properties of the different materials in the GCL, as well as the functionality and efficacy of these instrumentation and control systems within the GCL. This paper, Part I, describes the overall preliminary conceptual design of the VTR helium cartridge loop, the design of a fission product venting system, the thermal-hydraulic effects of flow direction, and gamma-heating generation in the cartridge. This paper also describes a three-dimensional computational fluid dynamics study that was carried out to examine the effects of the helium flow direction in the GCL on its thermal-hydraulic characteristics, engineering feasibility, and in-VTR experiment design. Both steady-state operation and a transient scenario (pressurized loss of forced circulation) were analyzed for the upward and downward helium flow options in the test article section in the GCL to provide quantitative data for selection of the helium flow direction. Additional analyses and development, as well as integrated out-of-pile testing, are planned to demonstrate and verify the performance of the GCL prior to insertion into the VTR.ISSN:0029-5639ISSN:1943-748

Preconceptual Design of Multifunctional Gas-Cooled Cartridge Loop for the Versatile Test Reactor: Instrumentation and Measurement—Part II

An integrated effort by the Versatile Test Reactor (VTR) Gas-Cooled Fast Reactor (GFR) Team to develop an experiment vehicle or extended-length test assembly for the VTR experiments is led by Idaho National Laboratory and supported by an industrial partner, General Atomics, and university partners, including Texas A&M University, University of Michigan, Oregon State University, University of Houston, and University of Idaho. The focus of the effort is to design a helium gas-cooled cartridge loop (GCL) to assist with the testing of fuels, materials, and instrumentation to further support development of advanced reactor systems. This study is divided into two parts. Part I provides the functional requirements and critical irradiation data needs for advancing gas-cooled fast reactor (GFR) technologies. The objective of Part I is to describe the overall preliminary conceptual design of the VTR helium cartridge loop, the design of a fission product venting system, thermal-hydraulic effects of flow direction, and gamma-heating generation in the cartridge. This paper, Part II, includes the measurement techniques being developed to measure the thermophysical properties of the different materials that make up the GCL, as well as the instrumentation and control system within the cartridge required for advancing GFR technologies. The purpose of Part II is to describe the functionality and efficacy of the measuring systems being developed to support the GCL. These systems include (a) a unique measurement platform that joins ion irradiation and a laser beam with an infrared camera and X-ray detection equipment developed and used to investigate more accurately and efficiently the influence of radiation and fission gases on the material properties under high temperatures; (b) a laser-induced breakdown spectroscopy to demonstrate its capability of monitoring possible fuel failure by detecting sub–part-per-million levels of xenon in the helium coolant stream, providing experimental data to better understand the interactions of fuel elements and coolant at high temperature, pressure, and fast neutron flux; (c) fiber-optic sensors with the ability to measure both the temperature demonstrated using a three-dimensional printed heat exchanger and, potentially, the strain in harsh environments; and (d) surface emissivity measurement test rigs to understand the effect of temperature, radiation, and surface finish on the silicon carbide cladding surface emissivity. Additional analyses and development, as well as integrated out-of-pile testing, are planned to demonstrate and validate the accuracy of the measuring systems and instrumentation in a more prototypic environment prior to their implementation into the VTRISSN:0029-5639ISSN:1943-748