Sustainable energy for whom? Governing pro-poor, low-carbon pathways to development: lessons from solar PV in Kenya

Using a combination of insights from innovation studies, sociotechnical transitions theory and the STEPS pathways approach, this paper analyses the evolution of the Kenyan photovoltaics (PV) market. Considered by many to be an exemplar of private sector led development, the Kenyan PV market has witnessed the adoption of more than 300,000 solar home systems and over 100,000 solar portable lights. The notion of an entrepreneurially driven unsubsidised solar market has proved to be a powerful narrative amongst development actors who, paradoxically, have provided millions of dollars of funding to encourage the market’s development. We argue that this donor support has been critical to the success of the market, but not simply by helping to create an enabling environment in which entrepreneurs can flourish. Donor assistance has been critical in supporting a range of actors to build the elements of a PV innovation system by providing active protection for experimentation, network-building, and the construction of shared visions amongst actors throughout supply chains and amongst users.This analysis gives important clues for designing climate and development policies, with implications for the governance of energy access pathways that are inclusive of poor and marginalised groups in low income countries

Innovation histories workshop on the solar home system market in Kenya

This report presents proceedings of an innovation histories workshop on the Solar Home System (SHS) Market in Kenya. The workshop was held on 3 June 2013 at Silver Springs Hotel in Nairobi Kenya. Stakeholders in the SHS market convened to reflect, draw on, capture and share thoughts and experiences to develop a comprehensive national innovation history, illustrating actions of key actors in Kenya who have contributed to the success of the Kenyan SHS market. Stakeholders from the United Kingdom and Kenya comprised researchers, policymakers, private sector actors and the media. The one-day workshop saw the participants developing a personal innovation history timeline as well as contributing through participatory and interactive approaches to develop a national SHS innovation history timeline. Participants expressed satisfaction in the process that led to the development of the innovation history timeline and expressed interest to participate in any future research and workshop on the subject

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005 and 2011 at a single institution were reviewed. Triplet neoadjuvant chemotherapy consisting of platinum, fluoropyrimidine and anthracycline was considered for operable patients (World Health Organization performance status ? 2) with clinical stage T2-4 N0-1. Response to neoadjuvant chemotherapy (NAC) was assessed using TRG, as described by Mandard et al. In addition lymph node downstaging was also assessed. Lymph node downstaging was defined by cN1 at diagnosis: assessed radiologically (computed tomography, positron emission tomography, endoscopic ultrasonography), then pathologically recorded as N0 after surgery; ypN0 if NAC given prior to surgery, or pN0 if surgery alone. Patients were followed up for 5 years post surgery. Recurrence was defined radiologically, with or without pathological confirmation. An association was examined between t TRG and lymph node downstaging with disease free survival (DFS) and a comprehensive range of clinicopathological characteristics.RESULTS: Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years (median follow up: 2.552, 95%CI: 2.022-3.081). There was a 1.8% (n = 4) inpatient mortality rate. One hundred and thirty-six (62.4%) patients received NAC, with 74.3% (n = 101) of patients demonstrating some signs of pathological tumour regression (TRG 1-4) and 5.9% (n = 8) having a complete pathological response. Forty four point one percent (n = 60) had downstaging of their nodal disease (cN1 to ypN0), compared to only 15.9% (n = 13) that underwent surgery alone (pre-operatively overstaged: cN1 to pN0), (P < 0.0001). Response to NAC was associated with significantly increased DFS (mean DFS; TRG 1-2: 5.1 years, 95%CI: 4.6-5.6 vs TRG 3-5: 2.8 years, 95%CI: 2.2-3.3, P < 0.0001). Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC (median DFS; TRG 3-5 and nodal down-staging: 5.533 years, 95%CI: 3.558-7.531 vs TRG 3-5 and no nodal down-staging: 1.114 years, 95%CI: 0.961-1.267, P < 0.0001).CONCLUSION: Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS

Multilevel modelling approach to analysing life course socioeconomic status and understanding missingness

This paper investigated the extent to which parental socioeconomic status was associated with life course socioeconomic status heterogeneity between adult cohort members of the 1958 National Child Development Study and how this association differed depending on methods used to address longitudinal missing data. We compared three variants of the full information maximum likelihood approach, namely available case, complete case and partially observed case and two methods designed to compensate for missing at random data, namely multilevel multiple imputation and multiple imputation chained equations. Our results highlighted the important contribution of parental socioeconomic status in explaining the divergence in achieved socioeconomic status over the adult life course, how the available case approach increasingly overestimated socioeconomic attainment as age increased and survey sample size decreased and how the complete case approach downwardly biased the effect of parental socioeconomic status on adult socioeconomic status

Bovine Tuberculosis in Britain and Ireland – A Perfect Storm? the Confluence of Potential Ecological and Epidemiological Impediments to Controlling a Chronic Infectious Disease

Publication history: Accepted - 3 May 2018; Published online - 5 June 2018Successful eradication schemes for bovine tuberculosis (bTB) have been implemented in a number of European and other countries over the last 50 years. However, the islands of Britain and Ireland remain a significant aberration to this trend, with the recent exception of Scotland. Why have eradication schemes failed within these countries, while apparently similar programs have been successful elsewhere? While significant socioeconomic and political factors have been discussed elsewhere as key determinants of disease eradication, here we review some of the potential ecological and epidemiological constraints that are present in these islands relative to other parts of Europe. We argue that the convergence of these potential factors may interact additively to diminish the potential of the present control programs to achieve eradication. Issues identified include heterogeneity of diagnostic testing approaches, the presence of an abundant wildlife reservoir of infection and the challenge of sustainably managing this risk effectively; the nature, size, density and network structure of cattle farming; potential effects of Mycobacterium bovis strain heterogeneity on disease transmission dynamics; possible impacts of concurrent endemic infections on the disclosure of truly infected animals; climatological differences and change coupled with environmental contamination. We further argue that control and eradication of this complex disease may benefit from an ecosystem level approach to management. We hope that this perspective can stimulate a new conversation about the many factors potentially impacting bTB eradication schemes in Britain and Ireland and possibly stimulate new research in the areas identified.Authors' work is funded by the Department of Agriculture, Environment and Rural Affairs, Northern Ireland (DAERA-NI