Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population

Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding cytochrome P450 2C subfamily, enzymes involved in biosynthesis of EETs, are associated with the risk of coronary heart diseas

The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population

The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) of CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), and CYP2C19 (rs4244285) are associated with susceptibility to EH in Russian populatio

Lipid-Associated GWAS Loci Predict Antiatherogenic Effects of Rosuvastatin in Patients with Coronary Artery Disease

We have shown that lipid-associated loci discovered by genome-wide association studies (GWAS) have pleiotropic effects on lipid metabolism, carotid intima-media thickness (CIMT), and CAD risk. Here, we investigated the impact of lipid-associated GWAS loci on the efficacy of rosuvastatin therapy in terms of changes in plasma lipid levels and CIM

A novel polymorphism in the promoter of the CYP4A11 gene is associated with susceptibility to coronary artery disease

Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population. In silico analysis allowed identifying that SNP rs9332978 is located at a binding site for multiple transcription factors; many of them are known to regulate the pathways involved in the pathogenesis of CA

Pharmacogenetic loci for rosuvastatin are associated with intima-media thickness change and coronary artery disease risk

The present study investigated whether polymorphisms at these genes are associated with the risk of coronary artery disease (CAD) development, and reduction of atherogenic lipids and carotid intima-media thickness (CIMT) in CAD patients, taking rosuvastati

The study of quality of life in patients with coronary artery disease using the SF-36 questionnaire

It was conducted a simple prospective study of the effect of lipid-lowering therapy in the assessment of quality of life using the SF-36 in IHD in men before and after pharmacological intervention. We did not have a statistically significant difference in the dynamics of scales SF-36 questionnaire both before treatment and after in patients with coronary heart disease, stable angina FC I-II with atherogenic GLP-sensitive rosuvastatin treatment, in comparison with a group of patients who switched to bi-component therapy. However, in the analysis of the personal data of patients with coronary artery disease based on genotype found that the original values of quality of life on the scale of SF-36 in media D allele polymorphism ACE I/D is different from that in comparison with the native I allele. Thus, patients are carriers of D allele showed initially a bad score for quality of life and less dynamic values on the scales of SF-36, regardless of the type of pharmacological correction of disorders of lipid metabolism. Therefore, from the point of view of preventive approach is of interest to link genetic and personal-behavioral characteristics considered as psychological factors of CHD risk

French linguoculture and methods of language and discourse representation of emotion "joie" (joy)

The article is devoted to the identification of ethnocultural methods of linguistic representation of the emotion "joy" in the French language and culture. The analysis of linguistic material is based on a cognitive and functional-communicative approach to its interpretatio

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population

Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding cytochrome P450 2C subfamily, enzymes involved in biosynthesis of EETs, are associated with the risk of coronary heart diseas