36 research outputs found
Tuning gastropod locomotion: Modeling the influence of mucus rheology on the cost of crawling
Common gastropods such as snails crawl on a solid substrate by propagating
muscular waves of shear stress on a viscoelastic mucus. Producing the mucus
accounts for the largest component in the gastropod's energy budget, more than
twenty times the amount of mechanical work used in crawling. Using a simple
mechanical model, we show that the shear-thinning properties of the mucus favor
a decrease in the amount of mucus necessary for crawling, thereby decreasing
the overall energetic cost of locomotion.Comment: Corrected typo
Centrolobular liver fibrosis in the hypercholesterolemic rabbit
During a study on the development of atheromatous lesions in rabbits fed a diet with a low or high cholesterol supplement, we found a moderate to pronounced centrolobular liver fibrosis. This fibrosis developed in three stages. Early after supplementation of cholesterol, we observed increased immunoreactivity of collagen types I, III, and IV, and fibronectin, around central veins and in adjacent sinusoids. In the second stage, we observed further increase of collagen and fibronectin immunoreactivity, together with the appearance of α-smooth muscle actin (α-SM actin)-positive cells and anti-rabbit macrophage monoclonal antibody (RAM 11)-positive cells. In the third stage, we observed large numbers of α-SM actin-positive cells, together with heavy deposition of connective tissue proteins in pericentral sinusoids, in addition to focal atrophy of parenchymal cells. By transmission electron microscopy (TEM), fat-storing cells in the pericentral regions were shown to be enlarged, to lose their lipid-droplets, and to acquire dilated rough endoplasmic reticulum corresponding to an activated phenotype. Parenchymal cells were either normal or contained numerous small lipid- droplets. They sometimes were smaller and distorted. Northern hybridization performed on total RNA of whole liver showed an increased level of collagen α1(I), α1(III), and α1(IV) messenger RNA (mRNA) after 24 weeks of low dietary cholesterol supplementation. These data show enhanced expression of extracellular matrix proteins. We conclude that cholesterol overload induces pericentral liver fibrosis in rabbits. The diet clearly activates fat- storing cells to become fibrogenic effector cells. At present, we have no explanation why hypercholesterolemia induces phenotypic transition of fat- storing cells.SCOPUS: ar.jinfo:eu-repo/semantics/publishe