I. The mechanism of the basic hydrolysis of dibromochloromethane and dibromofluoromethane ; II. An attempted synthesis of cyclobutene

M.S.Jack Hin

A Contribution to the Defense of Liquid Democracy

Liquid democracy is a hybrid direct-representative decision making process that provides each voter with the option of either voting directly or to delegate their vote to another voter, i.e., to a representative of their choice. One of the proposed advantages of liquid democracy is that, in general, it is assumed that voters will delegate their vote to others that are better informed, which leads to more informed and better decisions. Considering an audience from various knowledge domains, we provide an accessible high-level analysis of a prominent critique of liquid democracy by Caragiannis and Micha. Caragiannis and Micha's critique contains three central topics: 1. Analysis using their $\alpha$-delegation model, which does not assume delegation to the more informed; 2. Novel delegation network structures where it is advantageous to delegate to the less informed rather than the more informed; and 3. Due to NP hardness, the implied impracticability of a social network obtaining an optimal delegation structure. We show that in the real world, Caragiannis and Micha's critique of liquid democracy has little or no relevance. Respectively, our critique is based on: 1. The identification of incorrect $\alpha$-delegation model assumptions; 2. A lack of novel delegation structures and their effect in a real-world implementation of liquid democracy, which would be guaranteed with constraints that sensibly distribute voting power; and 3. The irrelevance of an optimal delegation structure if the correct result is guaranteed regardless. We conclude that Caragiannis and Micha's critique has no significant negative relevance to the proposition of liquid democracy

Deriving prevalence estimates of depressive symptoms throughout middle and old age in those living in the community

BACKGROUND: There is considerable debate about the prevalence of depression in old age. Epidemiological surveys and clinical studies indicate mixed evidence for the association between depression and increasing age. We examined the prevalence of probable depression in the middle aged to the oldest old in a project designed specifically to investigate the aging process. METHODS: Community-living participants were drawn from several Australian longitudinal studies of aging that contributed to the Dynamic Analyses to Optimise Ageing (DYNOPTA) project. Different depression scales from the contributing studies were harmonized to create a binary variable that reflected "probable depression" based on existing cut-points for each harmonized scale. Weighted prevalence was benchmarked to the Australian population which could be compared with findings from the 1997 and 2007 National Surveys of Mental Health and Well-Being (NSMHWB). RESULTS: In the DYNOPTA project, females were more likely to report probable depression. This was consistent across age levels. Both NSMHWB surveys and DYNOPTA did not report a decline in the likelihood of reporting probable depression for the oldest old in comparison with mid-life. CONCLUSIONS: Inconsistency in the reports of late-life depression prevalence in previous epidemiological studies may be explained by either the exclusion and/or limited sampling of the oldest old. DYNOPTA addresses these limitations and the results indicated no change in the likelihood of reporting depression with increasing age. Further research should extend these findings to examine within-person change in a longitudinal context and control for health covariates.NHMRC (National Health and Medical Research Council of Australia

Refining the definition of mandibular osteoradionecrosis in clinical trials: The cancer research UK HOPON trial (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis)

Introduction:Mandibular osteoradionecrosis (ORN) is a common and serious complication of head andneck radiotherapy for which there is little reliable evidence for prevention or treatment. The diagnosisand classification of ORN have been inconsistently and imprecisely defined, even in clinical trials.Methods:A systematic review of diagnosis and classifications of ORN with specific focus on clinical trialsis presented. The most suitable classification was evaluated for consistency using blinded independentreview of outcome data (clinical photographs and radiographs) in the HOPON trial.Results:Of 16 ORN classifications found, only one (Notani) appeared suitable as an endpoint in clinicaltrials. Clinical records of 217 timepoints were analysed amongst 94 randomised patients in theHOPON trial. The only inconsistency in classification arose where minor bone spicules (MBS) were appar-ent, which occurred in 19% of patients. Some trial investigators judged MBS as clinically unimportant andnot reflecting ORN, others classified as ORN based on rigid definitions in common clinical use. When MBSwas added as a distinct category to the Notani classification this ambiguity was resolved and agreementbetween observers was achieved.Discussion:Most definitions and clinical classifications are based on retrospective case series and may beunsuitable for prospective interventional trials of ORN prevention or treatment. When ORN is used as aprimary or secondary outcome in prospective clinical trials, the use of Notani classification with the addi-tional category of MBS is recommended as it avoids subjectivity and enhances reliability and consistencyof reporting

A contribution to the defense of liquid democracy

Liquid democracy is a hybrid direct-representative decision making process that provides each voter with the option of either voting directly or to delegate their vote to another voter, i.e., to a representative of their choice. One of the proposed advantages of liquid democracy is that, in general, it is assumed that voters will delegate their vote to others that are better informed, which leads to more informed and better decisions. Considering an audience from various knowledge domains, we provide an accessible high-level analysis of a prominent critique of liquid democracy by Caragiannis and Micha. Caragiannis and Micha's critique contains three central topics: 1. Analysis using their $\alpha$-delegation model, which does not assume delegation to the more informed; 2. Novel delegation network structures where it is advantageous to delegate to the less informed rather than the more informed; and 3. Due to NP hardness, the implied impracticability of a social network obtaining an optimal delegation structure. We show that in the real world, Caragiannis and Micha's critique of liquid democracy has little or no relevance. Respectively, our critique is based on: 1. The identification of incorrect $\alpha$-delegation model assumptions; 2. A lack of novel delegation structures and their effect in a real-world implementation of liquid democracy, which would be guaranteed with constraints that sensibly distribute voting power; and 3. The irrelevance of an optimal delegation structure if the correct result is guaranteed regardless. We conclude that Caragiannis and Micha's critique has no significant negative relevance to the proposition of liquid democracy

Testing the Scalar Triplet Solution to CDF's Fat WW Problem at the LHC

The Type II Seesaw model remains a popular and viable explanation of neutrino masses and mixing angles. By hypothesizing the existence of a scalar that is a triplet under the weak gauge interaction, the model predicts strong correlations among neutrino oscillation parameters, signals at lepton flavor experiments, and collider observables at high energies. We investigate reports that the Type II Seesaw can naturally accommodate recent measurements by the CDF collaboration, which finds the mass of the $W$ boson to be significantly larger than allowed by electroweak precision data, while simultaneously evading constraints from direct searches. Experimental scrutiny of this parameter space in the Type II Seesaw has long been evaded since it is not characterized by ``golden channels'' at colliders but instead by cascade decays, moderate mass splittings, and many soft final states. In this work, we test this parameter space against publicly released measurements made at the Large Hadron Collider. By employing a newly developed tool chain combining MadGraph5\_aMC@NLO and Contur, we find that most of the favored space for this discrepancy is already excluded by measurements of Standard Model final states. We give suggestions for further exploration at Run III of the LHC, which is now underway.Comment: 8 pages (incl. refs.), 3 figures; minor clarifications, matches published versio

Testing the scalar triplet solution to CDF’s heavy W problem at the LHC

The type II seesaw model remains a popular and viable explanation of neutrino masses and mixing angles. By hypothesizing the existence of a scalar that is a triplet under the weak gauge interaction, the model predicts strong correlations among neutrino oscillation parameters, signals at lepton flavor experiments, and collider observables at high energies. We investigate reports that the type II seesaw can naturally accommodate recent measurements by the CDF collaboration, which finds the mass of the W boson to be significantly larger than allowed by electroweak precision data, while simultaneously evading constraints from direct searches. Experimental scrutiny of this parameter space in the type II seesaw has long been evaded since it is not characterized by “golden channels” at colliders but instead by cascade decays, moderate mass splittings, and many soft final states. In this work, we test this parameter space against publicly released measurements made at the Large Hadron Collider. By employing a newly developed tool chain combining MadGraph5_AMC@NLO and CONTUR, we find that most of the favored space for this discrepancy is already excluded by measurements of Standard Model final states. We give suggestions for further exploration at run III of the LHC, which is now under way

Psychomotor Impairment Detection via Finger Interactions with a Computer Keyboard During Natural Typing

Modern digital devices and appliances are capable of monitoring the timing of button presses, or finger interactions in general, with a sub-millisecond accuracy. However, the massive amount of high resolution temporal information that these devices could collect is currently being discarded. Multiple studies have shown that the act of pressing a button triggers well defined brain areas which are known to be affected by motor-compromised conditions. In this study, we demonstrate that the daily interaction with a computer keyboard can be employed as means to observe and potentially quantify psychomotor impairment. We induced a psychomotor impairment via a sleep inertia paradigm in 14 healthy subjects, which is detected by our classifier with an Area Under the ROC Curve (AUC) of 0.93/0.91. The detection relies on novel features derived from key-hold times acquired on standard computer keyboards during an uncontrolled typing task. These features correlate with the progression to psychomotor impairment (p < 0.001) regardless of the content and language of the text typed, and perform consistently with different keyboards. The ability to acquire longitudinal measurements of subtle motor changes from a digital device without altering its functionality may allow for early screening and follow-up of motor-compromised neurodegenerative conditions, psychological disorders or intoxication at a negligible cost in the general population.Comunidad de Madri

Provider-initiated symptom screening for tuberculosis in Zimbabwe: diagnostic value and the effect of HIV status.

OBJECTIVE: To assess the diagnostic value of provider-initiated symptom screening for tuberculosis (TB) and how HIV status affects it. METHODS: We performed a secondary analysis of randomly selected participants in a community-based TB-HIV prevalence survey in Harare, Zimbabwe. All completed a five-symptom questionnaire and underwent sputum TB culture and HIV testing. We calculated the sensitivity, specificity, and positive and negative predictive values of various symptoms and used regression analysis to investigate the relationship between symptoms and TB disease. FINDINGS: We found one or more symptoms of TB in 21.2% of 1858 HIV-positive (HIV+) and 9.9% of 7121 HIV-negative (HIV-) participants (P or = 2 weeks' duration, any symptom and a positive sputum culture had sensitivities of 48%, 81% and 65%, respectively; in HIV- participants, the sensitivities were 45%, 71% and 74%, respectively. Symptoms had a similar sensitivity and specificity in HIV+ and HIV- participants, but in HIV+ participants they had a higher positive and a lower negative predictive value. CONCLUSION: Even smear-positive TB may be missed by provider-initiated symptom screening, especially in HIV+ individuals. Symptom screening is useful for ruling out TB, but better TB diagnostics are urgently needed for resource-poor settings

Gender differences in the trajectories of late-life depressive symptomology and probable depression in the years prior to death

BACKGROUND: Gender differences in depression are well established. Whether these differences persist into late life and in the years preceding death is less clear. There is a suggestion that there is no increased likelihood of depression in late life, but that there is an increase in depressive symptomology, particularly with proximity to death. We compared trajectories of probable depression and depressive symptomology between men and women over age and distance-to-death metrics to determine whether reports of depressive symptoms are more strongly related to age or mortality. METHODS: Participants (N = 2,852) from the Dynamic Analyses to Optimise Ageing (DYNOPTA) project had a mean age of 75 years (SD = 5.68 years) at baseline and were observed for up to 16 years prior to death. Multi-level regression models estimated change in depressive symptomology and probable depression over two time metrics, increasing age, and distance-to-death. RESULTS: Increases in depressive symptomology were reported over increasing age and in the years approaching death. Only male participants reported increased probable depression in the years preceding death. Models that utilized distance-to-death metrics better represented changes in late-life depression, although any changes in depression appear to be accounted for by co-varying physical health status. CONCLUSIONS: As death approaches, there are increases in the levels of depressive symptomology even after controlling for socio-demographic and health covariates. In line with increases in suicide rates in late life, male participants were at greater risk of reporting increases in depressive symptomology.NHMRC (National Health and Medical Research Council of Australia