Adult users’ perceptions of library services provided by Nongoma Public Library, Kwazulu-Natal.

Masters Degree. University of KwaZulu-Natal, Pietermaritzburg.The study investigated adult users’ perceptions of the library services provided by the Nongoma Public Library (NPL) in KwaZulu-Natal (KZN). It examined the quality of service provided by the library to its adult library users, by determining their expectations and perceptions of the services provided and whether there were any gaps between users’ expectations and perceptions. It also investigated users’ level of satisfaction with the quality of services rendered. Since its inception in 1996 and despite its importance, no assessment of the NPL had been conducted from the perspective of its users. This study intended to fill this gap and it is assumed that the findings will form a baseline and framework for future services provided by the library. Using convenience sampling a sample of 262 adults was selected from the 819 registered adult library users. One hundred and thirteen (113) users completed the questionnaire giving a response rate of 43.1% which was considered acceptable for purposes of analysis and reporting. The study adopted a quantitative approach using the survey design. The LibQUAL+TM survey instrument which was used to collect data was modified and adapted for use in a public library. In line with the quantitative approach, the majority of the questions asked were closed. The results from the questionnaire survey were analysed using SPSS to determine the frequency of responses and were presented in the form of tables and figures. The results of the survey support the usefulness of the LibQUAL+TM instrument used in the study and its importance in the context of public library services. The findings indicate that in most instances, expectations exceeded perceptions regarding the quality of the services provided by the library. However, the gaps between the two were, for the most part, not significant and the extent of the gap depended on the individual services. Significant gaps were found in the categories “Library facility” and “Access to information”. Certain aspects of the category “Staff services” were found to be of concern. Findings revealed that the majority of adult users ranked the overall quality of services as good and that the library is, to a large extent, excelling in service provision. Based on the findings, recommendations were made to address the problems identified in the study. The results will be used for service improvements and to make informed decisions concerning the quality of services that are offered at the NPL. The thesis concluded with suggestions for further research. The findings of the survey that indicated that although the adult library users were satisfied with library services they received from Nongoma Public Library but there was a room for improvement. The respondents mentioned the most problematic services as the lack of adequate computers and access to Internet. The respondents further reported that there were gaps in sections involving Access to Information, Access to Electronic Resources, Library Staff and the Library facility. The study recommends that service quality be improved, in a way that the library would satisfy its adult user

A critical examination of the defence of parody to a claim of copyright infringement, with particular reference to South African copyright law.

Thesis (LL.M.)-University of KwaZulu-Natal, Durban, 2013.No abstract available

A metabolomic landscape of maize plants treated with a microbial biostimulant under well-watered and drought conditions

Microbial plant biostimulants have been successfully applied to improve plant growth, stress resilience and productivity. However, the mechanisms of action of biostimulants are still enigmatic, which is the main bottleneck for the fully realization and implementation of biostimulants into the agricultural industry. Here, we report the elucidation of a global metabolic landscape of maize (Zea mays L) leaves in response to a microbial biostimulant, under well-watered and drought conditions. The study reveals that the increased pool of tricarboxylic acid (TCA) intermediates, alterations in amino acid levels and differential changes in phenolics and lipids are key metabolic signatures induced by the application of the microbial-based biostimulant. These reconfigurations of metabolism gravitate toward growth-promotion and defense preconditioning of the plant. Furthermore, the application of microbial biostimulant conferred enhanced drought resilience to maize plants via altering key metabolic pathways involved in drought resistance mechanisms such as the redox homeostasis, strengthening of the plant cell wall, osmoregulation, energy production and membrane remodeling. For the first time, we show key molecular events, metabolic reprogramming, activated by a microbial biostimulant for plant growth promotion and defense priming. Thus, these elucidated metabolomic insights contribute to ongoing efforts in decoding modes of action of biostimulants and generating fundamental scientific knowledgebase that is necessary for the development of the plant biostimulants industry, for sustainable food security

Metabolic Circuits in Sap Extracts Reflect the Effects of a Microbial Biostimulant on Maize Metabolism under Drought Conditions

The use of microbial biostimulants in the agricultural sector is increasingly gaining momentum and drawing scientific attention to decode the molecular interactions between the biostimulants and plants. Although these biostimulants have been shown to improve plant health and development, the underlying molecular phenomenology remains enigmatic. Thus, this study is a metabolomics work to unravel metabolic circuits in sap extracts from maize plants treated with a microbial biostimulant, under normal and drought conditions. The biostimulant, which was a consortium of different Bacilli strains, was applied at the planting stage, followed by drought stress application. The maize sap extracts were collected at 5 weeks after emergence, and the extracted metabolites were analyzed on liquid chromatography-mass spectrometry platforms. The acquired data were mined using chemometrics and bioinformatics tools. The results showed that under both well-watered and drought stress conditions, the application of the biostimulant led to differential changes in the profiles of amino acids, hormones, TCA intermediates, phenolics, steviol glycosides and oxylipins. These metabolic changes spanned several biological pathways and involved a high correlation of the biochemical as well as structural metabolic relationships that coordinate the maize metabolism. The hypothetical model, postulated from this study, describes metabolic events induced by the microbial biostimulant for growth promotion and enhanced defences. Such understanding of biostimulant-induced changes in maize sap pinpoints to the biochemistry and molecular mechanisms that govern the biostimulant–plant interactions, which contribute to ongoing efforts to generate actionable knowledge of the molecular and physiological mechanisms that define modes of action of biostimulants

Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study

BackgroundTwo phase 3 clinical trials showed that use of a monthly vaginal ring containing 25 mg dapivirine was well tolerated and reduced HIV-1 incidence in women by approximately 30% compared with placebo. We aimed to evaluate use and safety of the dapivirine vaginal ring (DVR) in open-label settings with high background rates of HIV-1 infection, an important step for future implementation.MethodsWe did a phase 3B open-label extension trial of the DVR (MTN-025/HIV Open-label Prevention Extension [HOPE]). Women who were HIV-1-negative and had participated in the MTN-020/ASPIRE phase 3 trial were offered 12 months of access to the DVR at 14 clinical research centres in Malawi, South Africa, Uganda, and Zimbabwe. At each visit (monthly for 3 months, then once every 3 months), women chose whether or not to accept the offer of the ring. Used, returned rings were tested for residual amounts of dapivirine as a surrogate marker for adherence. HIV-1 serological testing was done at each visit. Dapivirine amounts in returned rings and HIV-1 incidence were compared with data from the ASPIRE trial, and safety was assessed. This study is registered with ClinicalTrials.gov, NCT02858037.FindingsBetween July 16, 2016, and Oct 10, 2018, of 1756 women assessed for eligibility, 1456 were enrolled and participated in the study. Median age was 31 years (IQR 27-37). At baseline, 1342 (92·2%) women chose to take the DVR; ring acceptance was more than 79% at each visit up until 12 months and 936 (73·2%) of 1279 chose to take the ring at all visits. 12 530 (89·3%) of 14 034 returned rings had residual dapivirine amounts consistent with some use during the previous month (>0·9 mg released) and the mean dapivirine amount released was greater than in the ASPIRE trial (by 0·21 mg; p<0·0001). HIV-1 incidence was 2·7 per 100 person-years (95% CI 1·9-3·8, 35 infections), compared with an expected incidence of 4·4 per 100 person-years (3·2-5·8) among a population matched on age, site, and presence of a sexually transmitted infection from the placebo group of ASPIRE. No serious adverse events or grade 3 or higher adverse events observed were assessed as related to the DVR.InterpretationHigh uptake and persistent use in this open-label extension study support the DVR as an HIV-1 prevention option for women. With an increasing number of HIV-1 prophylaxis choices on the horizon, these results suggest that the DVR will be an acceptable and practical option for women in Africa.FundingThe Microbicide Trials Network and the National Institute of Allergy and Infectious Diseases, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health, all components of the US National Institutes of Health