Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Revista electrónica interuniversitaria de formación del profesorado

Monográfico con el título: 'La universidad de la convergencia. Acreditación y certificaciones. Estrategias docentes, tutoriales y evaluadoras de reforma'. Resumen basado en el de la publicaciónEl Espacio Europeo de Educación Superior (EEES) pone el acento en dos cuestiones básicas: el aprendizaje y el trabajo del alumno. Al hilo de ese discurso, se pretende dar a conocer las posibilidades del cuaderno de bitácora como recurso formativo y como instrumento de investigación-acción en el ámbito de la educación universitaria. La bitácora se presenta aquí como un instrumento al servicio de una pedagogía de la esperanza y de la autonomía, frente a la pedagogía de la sumisión, capaz de convertir el aula en un espacio reflexivo, crítico y comunicativo.AragónES