Zmiany funkcjonalne i metaboliczne u ludzi we włośnicy

By means of a complex biochemical and functional investigation of 26 trichinellosis patients in the acute stage, totalling 264 tests, the authors point out: the increase of serum pyruvate, a tendence towards hypoglycemia, hypoproteinemia with lowered albumins, increased γ-globulins and (less frequently) α₂-globulins; increase of urinary creatinine, increased glutamatepyruvate transaminase activity in the serum, diminished amount of 17-ketosteroids in the urine with positive Robinson test, a tendence towards increased serum phosphate and decreased serum potassium. The recorded data are interpreted as a result of a more intense catabolism of glucose and proteins, as produced by the dystrophic parasitary myositis and of the reversible hyposecretion of corticosuprarenal glands.Na podstawie kompleksowych badań biochemicznych i funkcjonalnych (264 próby) wykonanych u 26 pacjentów w ostrym stadium włośnicy autorzy stwierdzają: wzrost aktywności pirogronianu w surowicy, tendencję w kierunku hypoglikemii, hypoproteinemię z obniżoną ilością albumin, wzrost γ-globulin i (rzadziej) α₂-globulin, zwiększenie poziomu kreatyniny w moczu, wzrost aktywności transaminazy glutaminowa-pirogronianu w surowicy, obniżoną ilość 17-ketosteroidów w moczu z dodatnią próbą Robinsona, tendencją wzrostu fosforanów w surowicy i obniżenie potasu. Zmiany te są następstwem wzmożonego katabolizmu glukozy i białek, wywołanego dystroficznym pasożytniczym zapaleniem mięśni i odwrotną hyposckrecją gruczołów kory nadnercza

Zmiany funkcjonalne i metaboliczne u ludzi we włośnicy

By means of a complex biochemical and functional investigation of 26 trichinellosis patients in the acute stage, totalling 264 tests, the authors point out: the increase of serum pyruvate, a tendence towards hypoglycemia, hypoproteinemia with lowered albumins, increased γ-globulins and (less frequently) α₂-globulins; increase of urinary creatinine, increased glutamatepyruvate transaminase activity in the serum, diminished amount of 17-ketosteroids in the urine with positive Robinson test, a tendence towards increased serum phosphate and decreased serum potassium. The recorded data are interpreted as a result of a more intense catabolism of glucose and proteins, as produced by the dystrophic parasitary myositis and of the reversible hyposecretion of corticosuprarenal glands.Na podstawie kompleksowych badań biochemicznych i funkcjonalnych (264 próby) wykonanych u 26 pacjentów w ostrym stadium włośnicy autorzy stwierdzają: wzrost aktywności pirogronianu w surowicy, tendencję w kierunku hypoglikemii, hypoproteinemię z obniżoną ilością albumin, wzrost γ-globulin i (rzadziej) α₂-globulin, zwiększenie poziomu kreatyniny w moczu, wzrost aktywności transaminazy glutaminowa-pirogronianu w surowicy, obniżoną ilość 17-ketosteroidów w moczu z dodatnią próbą Robinsona, tendencją wzrostu fosforanów w surowicy i obniżenie potasu. Zmiany te są następstwem wzmożonego katabolizmu glukozy i białek, wywołanego dystroficznym pasożytniczym zapaleniem mięśni i odwrotną hyposckrecją gruczołów kory nadnercza

New antibacterial silver(I) coordination polymers based on a flexible ditopic pyrazolyl-type ligand

In the last two decades, a tremendous amount of attention has been directed towards the design of antibacterial silver(I)-based materials, including coordination polymers (CPs) built up with a great variety of oxygen and nitrogen-containing ligands. Herein, a family of six new silver(I)-based CPs, having the general stoechiometric formula [Ag(H2DMPMB)(X)] (X = NO3, 1; CF3CO2, 2; CF3SO3, 3; BF4, 4; ClO4, 5; and PF6, 6) and incorporating the flexible ditopic pyrazolyl-type ligand 4,40-bis((3,5-dimethyl-1H-pyrazol-4-yl)methyl)biphenyl (H2DMPMB), has been prepared by the chemical precipitation method involving the reaction of silver(I) salts with H2DMPMB in the 1:1 molar ratio, in alcohols, or acetonitrile at room temperature for two-hours. The new silver(I)-based polymeric materials were characterized by means of Fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), and thermogravimetric analysis (TGA), allowing for the proposition that their structures comprise one-dimensional chains, with the silver(I) ions mostly assuming a T-shapped stereochemistry completed by the exo-bidentate ligands and counter-anions. The obtained silver(I) CPs showed a remarkable light insensitivity and stability in the air, are insoluble in water and in most common organic solvents, and possess appreciable thermal stabilities spanning the range 250-350 °C. The antibacterial activity of the obtained silver(I) CPs was tested against the Gram-negative bacteria Escherichia coli (E. coli) and Gram-positive bacteria Staphylococcus aureus (S. aureus) using the Tetrazolium/Formazan test (TTC), by measuring the bacterial viability at different time intervals. The complete reduction of both bacterial strains occurred after 24 h of exposure to all silver(I) CPs, the bacterial viability values for S. aureus reaching 8% for compounds 3, 5, and 6 after only two-hours

The Association of Telangiectasias with Other Peripheral Vascular Lesions of Systemic Sclerosis

Carmen Bobeica,1,* Elena Niculet,2,3,* Carmina Liana Musat,2,* Lina Iancu,4 Mihaela Craescu,2,3 Andreea Mioara Luca,5 Bogdan Ioan Stefanescu,6 Emma Gheorghe,7 Mihaela Debita,8 Claudiu-Ionut Vasile,8 Gabriela Balan,8– 10 Camelia Busila,8 Alin Laurentiu Tatu3,8,11 1Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, 800008, Romania; 2Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, 800008, Romania; 3Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), “Dunărea de Jos” University, Galați, Romania; 4Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, 800008, Romania; 5Department of Plastic Surgery, “Sf. Ioan” Clinical Emergency Hospital for Children, Galați, 800487, Romania; 6Clinical Surgical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, Romania; 7Department No. 1 (Preclinical), Faculty of Medicine and Pharmacy, “Ovidius” University, Constanța, 900527, Romania; 8Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, 800008, Romania; 9Department of Gastroenterology, “Sf. Apostol Andrei” County Emergency Clinical Hospital, Galaţi, 800578, Romania; 10Research Center in the Field of Medical and Pharmaceutical Sciences, “Dunărea de Jos” University, Galaţi, 800008, Romania; 11Dermatology Department, “Sf. Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galați, 800179, Romania*These authors contributed equally to this workCorrespondence: Elena Niculet; Carmina Liana Musat, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, 35 Alexandru Ioan Cuza Street, Galați, 800216, Romania, Tel +40741398895 ; +40723338438, Email [email protected]; [email protected]: Systemic sclerosis (SSc) is a relatively rare collagenosis manifested as microvasculopathy, excessive cutaneous and visceral fibrosis in a background of autoimmune alteration. Autoimmune vasculopathy in SSc occurs early and begins with endothelial cell activation followed by blood vessel intimal proliferation in a context of defective angiogenesis. The alteration of peripheral micro and macrocirculation in SSc is evident through vascular lesions, such as Raynaud’s phenomenon, telangiectasias, acrocyanosis, digital ulcers, gangrene, peripheral pulse deficiency. Our paper details the results of the study on the association between telangiectasias and other types of immune-mediated peripheral vascular lesions that can be identified in SSc. The presence of these peripheral vascular lesions can provide information about the magnitude of the peripheral vasculopathy.Patients and Methods: A total of 37 patients diagnosed with SSc, recruited from a university clinic in Bucharest between February 2019 and March 2020, were enrolled in an observational study. We evaluated the presence of telangiectasias, as a stigma of autoimmune microvasculopathy, and their association with other immune-mediated peripheral vascular lesions that may be present in SSc.Results: The presence of telangiectasias was identified in the absence, but especially in the presence of acrocyanosis and digital ulcerations, and patients with peripheral pulse deficiency almost always had telangiectasias. Less than a quarter of the patients with digital ulcers progressed unfavorably to gangrene, and only one required amputation, telangiectasias being present not only in the patient with amputation but in all patients with gangrene.Conclusion: We appreciate that telangiectasias may be the clinical expression of peripheral vasculopathy characteristic of SSc, they can often be present in association with other peripheral vascular lesions and may represent a valuable indicator for the gangrene risk of digital ulcerations in SSc.Keywords: systemic sclerosis, vascular lesions, phenomenon Raynaud’s, telangiectasias, acrocianosis, digital ulcer

Grown of highly porous ZnO-nanoparticles by pulsed laser ablation in liquid technique for sensing applications

Pulsed laser ablation technique in deionized water with low laser fluency has been explored to prepare uniform dispersed porous ZnO nanoparticles for sensing applications. Surface morphology, particle size, porous structure, roughness, elemental distribution, and chemical bonding of the synthesized ZnO are analyzed by TEM, FESEM, AFM, EDX, and FTIR spectroscopy, respectively. Sensing behavior is observed by UV–Vis absorption measurements. TEM and FESEM analysis show that the prepared ZnO-coated film has homogeneous, dispersed, highly porous, and crack-free surface; the average particle size are observed ~ 24.72 ± 2.97 nm. The porous structure is responsible for appropriate sensing behavior. Low roughness value ~ 1.52 nm which is analyzed by AFM is advantageous for sensing behavior. EDX spectrum and elements mapping clearly show the uniform Zn and O distribution. XRD analysis confirms the hexagonal wurtzite structure of ZnO. FTIR reveals the Zn and O chemical bonding successfully. UV-Visible analysis exhibits that the prepared ZnO matrix has good incorporation with multi-dyes solutions at pH values 10–12 with significant changes in color behavior. The highest pKa value ~ 9.77 at a wavelength of 598.28 nm was calculated for multi-dyes immobilized ZnO matrix. So, it can be concluded that prepared ZnO nanostructures are potential candidates for sensing application