Single nucleotide polymorphisms in genes encoding xenobiotic metabolizing enzymes are associated with predisposition to arterial hypertension

To investigate the association of single nucleotide polymorphisms of genes involved in the biotransformation of xenobiotics (rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1799930 NAT2, rs1800566 NQO1, rs11045642 MDR1) with predisposition to arterial hypertensio

Hypoxia-inducible factor: basic biology and involvement in cardiovascular pathology

Molecular epidemiological studies conducted to date reveal a close relationship between the polymorphism of the HIF system genes with a wide range of cardiovascular, inflammatory, and oncological diseases. The study of the HIF system can contribute to the discovery of new targets and methods of pharmacological effects for the treatment of cardiovascular, oncological, rheumatological, and endocrinological patholog

Molecular-genetic factors of genital endometriosis

Article concerns data of the comparative analysis of polymorphic options of genes at patients with genital endometriosis and women in control grou

Genetic factors of pregnancy pathology

To study associations of genetic polymorphisms of cytokines with the risk of preeclampsia development. The study involved 250 pregnant women with preeclampsia and 245 women with a physiological pregnanc

Роль генов антиоксидантной защиты в развитии псевдоэксфолиативной глаукомы

PURPOSE: To study association of some antioxidant defense genes polymorphisms with pseudoexfoliative glaucoma (PXG). METHODS: 224 patients with PXG and 152 healthy controls were genotyped through polymerase chain reaction and restriction fragment length techniques for 3 antioxidant system genes polymorphisms: P1I105V of the glutathione S-transferase P1 (GSTP1), T718C of the glutathione peroxidase (GPX4) and Pro187Ser of the quinone oxidoreductase type 1 (NQO1). RESULTS: Presence of mutant allele Val105 of GSTP1 was associated with increased risk of PXG (OR=1.76, 95%CI 1.272.42). Val105Val genotype in PXG patients was determined four times more often than in control subjects (pЦЕЛЬ. Изучить ассоциацию полиморфизма некоторых генов ферментов антиоксидантной защиты с развитием псевдоэксфолиативной глаукомы (ПЭГ). МЕТОДЫ. Обследовано 224 пациента с ПЭГ и 152 офтальмологически здоровых лица, составивших контрольную группу. Проводилось генотипирование 3 полиморфизмов генов ферментов антиоксидантной системы (АОС) - глутатион-S-трансферазы P1 I105V (GSTP1), глутатионпероксидазы 4 типа T718C (GPX4) и НАДФ(Н) хинон оксидоредуктазы Pro187Ser (NQO1) методами полимеразной цепной реакции и рестрикционного анализа. РЕЗУЛЬТАТЫ. Установлено, что мутантный аллель Val105 гена GSTP1 чаще встречался у лиц, страдающих псевдоэксфолиативной глаукомой (ПЭГ) (OR=1,76, 95% Cl 1,27-2,42). Частота генотипа Val105Val гена GSTP1 была более чем в 4 раза выше в группе больных ПЭГ, чем в контроле (

Бурение осадков оз. Каракель (долина р. Теберда) и перспективы реконструкции истории оледенения и климата голоцена на Кавказе

Lacustrine sediments represent an important data source for glacial and palaeoclimatic reconstructions. Having a number of certain advantages, they can be successfully used as a means of specification of glacier situation and age of moraine deposits, as well as a basis for detailed climatic models of the Holocene. The article focuses on the coring of sediments of Lake Kakakel (Western Caucasus) that has its goal to clarify the Holocene climatic history for the region, providing the sampling methods, lithologic description of the sediment core, obtained radiocarbon dating and the element composition of the sediments. The primary outlook over the results of coring of the sediments of the Lake Karakyol helped to reconsider the conventional opinion on the glacial fluctuations in the valley of Teberda and to assume the future possibility for high-definition palaeoclimatic reconstruction for Western Caucasus.Озёрные отложения – важный источник данных для реконструкции колебаний ледников и изменений климата. Рассмотрены первые результаты бурения осадков оз. Каракель (долина р. Теберда, Западный Кавказ), выполненного для реконструкции голоценовой истории оледенения и климата в регионе. Описаны методика отбора образцов и особенности стратиграфии керна донных отложений оз. Каракель, приведены три радиоуглеродные датировки, позволившие оценить скорости осадконакопления в верхней части толщи (поздний голоцен). Датировка нижнего слоя озёрных отложений – 11 700 л.н. (календарный возраст) – одновременно представляет собой оценку минимального возраста морены, подпруживающей оз. Каракель

Genetic factors of pregnancy pathology

To study associations of genetic polymorphisms of cytokines with the risk of preeclampsia development. The study involved 250 pregnant women with preeclampsia and 245 women with a physiological pregnanc

Molecular-genetic factors of genital endometriosis

Article concerns data of the comparative analysis of polymorphic options of genes at patients with genital endometriosis and women in control grou

Apolipoprotein E gene polymorphisms: a relationship with the risk of coronary artery disease and the effectiveness of lipid-lowering therapy with rosuvastatin

Aim. To analyze the associations of apolipoprotein E (APOE) gene polymorphisms (rs7412 and rs4420638) with the risk of coronary artery disease (CAD) and the effectiveness of lipid-lowering therapy with rosuvastatin.Material and methods. The study involved the analysis of deoxyribonucleic acid samples and phenotypic data of 1700 unrelated individuals of Slavic origin, natives of Central Russia. A pharmacogenetic testing included 205 patients with CAD. Patients were prescribed rosuvastatin with determination of lipid levels and intima-media thickness (IMT) after 6 and 12 months of follow-up.Results. Carriers of the minor T allele for rs7412 polymorphism of the APOE gene were characterized by a lower CAD risk and a higher baseline level of low-density lipoprotein cholesterol (LDL-C). Associations of this polymorphism depended on body mass index. An association with an increased CAD risk was typical for male carriers of the variant G allele for rs4420638 polymorphism of the APOE gene. When treating CAD patients with rosuvas-tatin, a more pronounced lipid-lowering effect on total cholesterol and LDL-C was characteristic of individuals homozygous for the minor T allele for rs7412 of the APOE gene after 1 month of therapy; decrease of the lipidlowering effect with respect to total cholesterol took place in carriers of the heterozygous A/G genotype of rs4420638 polymorphism of the APOE gene after 12 months of therapy. An association was found between the rs7412 polymorphism of the APOE gene and the changes of maximum IMT in CAD patients treated with rosuvastatin. It consisted of the absence of IMT regression in T allele carriers after 6 months of lipid-lowering therapy.Conclusion. Polymorphisms of the APOE gene are associated with parameters of cholesterol metabolism, the risk of CAD and the effectiveness of lipid-lowering therapy with rosuvastatin

Coring of Karakel’ Lake sediments (Teberda River valley) and prospects for reconstruction of glaciation and Holocene climate history in the Caucasus

Lacustrine sediments represent an important data source for glacial and palaeoclimatic reconstructions. Having a number of certain advantages, they can be successfully used as a means of specification of glacier situation and age of moraine deposits, as well as a basis for detailed climatic models of the Holocene. The article focuses on the coring of sediments of Lake Kakakel (Western Caucasus) that has its goal to clarify the Holocene climatic history for the region, providing the sampling methods, lithologic description of the sediment core, obtained radiocarbon dating and the element composition of the sediments. The primary outlook over the results of coring of the sediments of the Lake Karakyol helped to reconsider the conventional opinion on the glacial fluctuations in the valley of Teberda and to assume the future possibility for high-definition palaeoclimatic reconstruction for Western Caucasus