20 research outputs found
Interprofessional collaboration: An exploration of possible prerequisites for successful implementation
No full textQuantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study
No full textSocial Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder:The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study
No full textLanguage deficits in specific language impairment, attention deficit/hyperactivity disorder, and autism spectrum disorder:An analysis of polygenic risk
Get PDFThe Danish High Risk and Resilience Study—VIA 11: Study Protocol for the First Follow-Up of the VIA 7 Cohort −522 Children Born to Parents With Schizophrenia Spectrum Disorders or Bipolar Disorder and Controls Being Re-examined for the First Time at Age 11
Get PDFExecutive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls: The Danish High Risk and Resilience Study—VIA 7, a population-based cohort study
No full textNeutralization assays on JR-FL glycan mutants indicate binding of inferred intermediate antibodies to both N301 and N332 on HIV-1 Env.
No full text<p>(<b>A</b>) Neutralization curves of inferred intermediate antibodies on wild-type JR-FL virus (<b>B</b>) JR-FL N301A mutant virus, and (<b>C</b>) JR-FL N332A mutant virus. (<b>D</b>) Neutralization curves of 3H+3L and (<b>E</b>) PGT121 on wild-type JR-FL virus compared to single and double glycan mutant viruses. (<b>F</b>) Neutralization curves of PGT121 on wild-type 92BR020 virus compared to single and double glycan mutant viruses.</p
Selected heavy and light chain clones were paired and tested for neutralization breadth and potency on a cross-clade 6-virus panel.
No full text<p>(<b>A</b>) Heavy and light chain nodes leading to mAb PGT121 and (<b>B</b>) PGT124 were paired and tested on a 74-virus panel of PGT121- or PGT124-sensitive viruses. Boxes are colored by IC<sub>50</sub> values (µg/ml) of each isolate neutralized.</p
Putative germline of PGT121 does not bind monomeric gp120 or cell surface Env.
No full text<p>(<b>A</b>) PGT121germline does not bind recombinant gp120 (92BR020). Recombinant gp120s were produced in 293F cells and purified by lectin column before use in ELISA binding assays. ELISA values are reported in optical density at 405 nm (OD405). (<b>B</b>) PGT121germline does not cell surface Env (92BR020). Cell surface Env was produced by transfecting pseudovirus in 293T cells and binding was measured by flow cytometry (reported in mean fluorescence intensity or MFI).</p
Higher levels of somatic hypermutation correlates with greater neutralization breadth and potency.
No full text<p>(<b>A</b>) Summary of neutralization data in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003754#ppat-1003754-g004" target="_blank">Figure 4A–B</a> by each clade neutralized. Listed in colored boxes are percentage values. (<b>B</b>) Overall mutation frequencies of mAb combinations, which were calculated by overall number of nucleotide mutations in both heavy and light chains divided by combined heavy and light chain lengths. The mutation frequency of each heavy and light chain was calculated over both V- and J-genes.</p
