Rethinking Sterilization Practices: Evidence for Event‐Related Outdating

A prospective study was conducted during a 2‐year period to evaluate the effectiveness of event‐related outdating. Hospitalprepared sterilized items (n = 152) were shelved in wards and every 3 months, several articles were retrieved and microbiologically tested. During the 2‐year period, all of the items tested were sterile

In vivo and ex vivo percutaneous absorption of [14C]-bisphenol A in rats: a possible extrapolation to human absorption?

Bisphenol A (BPA) is a monomer used mainly in the synthesis of polycarbonates and epoxy resins. Percutaneous absorption is the second source of exposure, after inhalation, in the work environment. However, studies on this route of absorption are lacking or incomplete. In this study, percutaneous BPA absorption was measured in vivo and ex vivo in the rat, and ex vivo in humans. An approximately 12-fold difference in permeability between rat skin and human skin was found, with permeability being higher in the rat. In addition, inter- and intra-individual variability of up to tenfold was observed in humans. No accumulation of BPA in the skin was found during exposure. The skin clearance rate following exposure was estimated at 0.4 μg/cm²/h. Ex vivo and in vivo percutaneous absorption fluxes of BPA in the rat were in the same range (about 2.0 μg/cm²/h), suggesting that extrapolation to the in vivo situation in humans may be possible. The European tolerable daily intake (TDI) of BPA is 50 μg/kg body weight. However, many research projects have highlighted the significant effects of BPA in rodents at doses lower than 10 μg/kg/day. A 1-h occupational exposure over 2,000 cm² (forearms and hands) may lead to a BPA absorption of 4 μg/kg/day. This is 8% of the European TDI and is very close to the value at which effects have been observed in animals. This absorption must therefore be taken into account when evaluating risks of BPA exposure, at least until more relevant results on the toxicity of BPA in humans are available

Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes

Transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CM) for cardiac regeneration is hampered by the formation of fibrotic tissue around the grafts, preventing electrophysiological coupling. Investigating this process, we found that: (1) beating hESC-CM in vitro are embedded in collagens, laminin and fibronectin, which they bind via appropriate integrins; (2) after transplantation into the mouse heart, hESC-CM continue to secrete collagen IV, XVIII and fibronectin; (3) integrin expression on hESC-CM largely matches the matrix type they encounter or secrete in vivo; (4) co-transplantation of hESC-derived endothelial cells and/or cardiac progenitors with hESC-CM results in the formation of functional capillaries; and (5) transplanted hESC-CM survive and mature in vivo for at least 24 weeks. These results form the basis of future developments aiming to reduce the adverse fibrotic reaction that currently complicates cell-based therapies for cardiac disease, and to provide an additional clue towards successful engraftment of cardiomyocytes by co-transplanting endothelial cells

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Preceptorship - making a difference

A preceptor project at the Royal Brisbane and Women's Hospital in Queensland, Australia, explored existing levels of preceptorship support during the transition processes of newly employed or transferred nurses and midwives. Initiatives adopted have enhanced the implementation and maintenance of preceptorship principles and communication processes and defined accountability and responsibilities. Outcomes have contributed to enhanced role clarity, improved communication, increased support for teaching and learning, and infrastructure processes to facilitate the preceptor-preceptee relationship and increased retention

Guide for University - Industry Integration

The Guide for University-Industry Integration (The Guide) is based on principles developed following testing of the University – Industry Integration Framework (The Framework) developed by Theobald, K., McCarthy, A., Henderson, A., Coyer, F., Shaban, R., Fox, R., & Thomson, B. (2019). As such, this provides a framework that can be used by nursing and midwifery academic and industry colleagues to consider new ways of working from a co-design perspective to formulate learning initiatives/opportunities based on a culture of shared decisions, relevance and agility established at the beginning of a joint venture

Leveraging university-industry partnerships to optimise postgraduate nursing education

BACKGROUND: Industry and higher education sectors devote considerable, but independent resources to deliver postgraduate nursing education. This leads to duplication, uncertainty among students, and critical gaps in nursing education. Establishing and sustaining meaningful partnerships between invested university and industry stakeholders can strengthen workforce capability and improve patient care.METHODS: To evaluate the feasibility and effectiveness of using a University-Industry Integration Framework to develop a postgraduate nursing education program. Prospective mixed methods cohort study (STROBE). A co-design approach, using an established University-Industry Integration Framework, leveraged expert stakeholder partnerships to contextualise knowledge and service need for developing a postgraduate education program for cancer care nurses.RESULTS: All participants (n = 46) were 100% satisfied with the online resources, support, and communication processes applied. Qualitative data generated three major analytical interpretations (reciprocity, flexible adaptations, authentic learning), highlighting the experiences and connections and how the partnership evolved. Program participants (n = 15) undertook a six-week cancer education program with eight responding to the survey with overwhelming satisfaction (100%), increasing their knowledge and skills. While barriers were evident, three quarters (n = 6) indicated these were addressed and enabled progress in the program. However, 63% (n = 5) were not satisfied with the program workload.CONCLUSIONS: University and industry partners can apply the University-Industry Integration Framework and deliver a successful postgraduate education program for cancer care services. Within a co-design partnership it is possible to develop strategies and processes to overcome barriers and deliver a program for mutual benefit. The culmination of this successful education program has enhanced collaborations between partners and likely will sustain the offering of future co-design endeavours.</p

SHPA standards of practice for the transportation of cytotoxic drugs from pharmacy departments

These are Standards of professional practice and not standards prepared or endorsed by Standards Australia. They are not legally binding

Enhancing postgraduate cancer nursing education through effective university-industry partnerships: InsPIRE

Introduction: Creating and sustaining meaningful partnerships between university and industry stakeholders can strengthen workforce capability and improve patient care. Cancer nurses require specialist knowledge and skills in order to deliver optimal care in a complex environment. To further workforce preparation, two large metropolitan cancer health services and a university worked in partnership to lead an academe/industry integration research project in cancer care education.Aim: To develop and implement a transitional cancer care program and evaluate the application of the University-Industry Integration Framework for newly employed nursing staff in cancer services. Methodology: A prospective mixed methods study evaluated the effectiveness of using a University-Industry Integration Framework to develop and deliver a transitional postgraduate cancer nursing education program. A co-design approach leveraged expert stakeholder partnerships to contextualise knowledge and service need, to develop the program. A partnership team and advisory committee led deliverables and governance. A product development working group developed and delivered resources for participants. Results: All participants (n=46) were satisfied (100%) with the online resources, support, and communication processes applied. Qualitative data generated three major analytical interpretations (reciprocity, flexible adaptations, authentic learning), highlighting the experiences and connections and how the partnership evolved. Program participants (n=15) undertook a six-week cancer transitional education program with eight responding to the survey with overwhelming satisfaction (100%), increasing their knowledge and skills. While barriers were evident, three quarters (n=6) indicated these were addressed and enabled progress in the program. However, 63% (n=5) were not satisfied with the program workload. Conclusion: This project demonstrated that university and industry stakeholders can effectively apply the University-Industry Integration Framework and deliver a conjoint transitional postgraduate cancer care education program to assist workforce preparation. This creative education program has enhanced collaborations between partners and led to further funding to continue to develop a sustainable program for state-wide use