Long‐term variability in the solar diurnal tide observed by HRDI and simulated by the GSWM

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94861/1/grl8658.pd

Stellar alignment of the High Resolution Doppler Imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77037/1/AIAA-26727-328.pd

Atmospheric wind measurements with the high-resolution Doppler imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76745/1/AIAA-26590-119.pd

Observations of the quasi 2‐day wave from the High Resolution Doppler Imager on Uars

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95387/1/grl7238.pd

Major surgery induces acute changes in measured DNA methylation associated with immune response pathways

Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels of DNA methylation in peripheral blood mononuclear cells (PBMCs) longitudinally collected from a cohort of elderly patients undergoing major surgery, comparing samples collected at baseline to those collected immediately post-operatively and at discharge from hospital. We identified acute changes in measured DNA methylation at sites annotated to immune system genes, paralleling changes in serum-levels of markers including C-reactive protein (CRP) and Interleukin 6 (IL-6) measured in the same individuals. Many of the observed changes in measured DNA methylation were consistent across different types of major surgery, although there was notable heterogeneity between surgery types at certain loci. The acute changes in measured DNA methylation induced by surgery are relatively stable in the post-operative period, generally persisting until discharge from hospital. Our results highlight the dramatic alterations in gene regulation induced by invasive surgery, primarily reflecting upregulation of the immune system in response to trauma, wound healing and anaesthesia.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.This work was supported by the Medical Research Council (Grant MR/M008924/1), the Sasakawa Foundation (Butterfield Awards B108) and the UK National Institute for Health Research (NIHR) Exeter Clinical Research Facility (Exeter CRF).Published version, Accepted version, Submitted versio

Intercalibration of HRDI and WINDII wind measurements

The High Resolution Doppler Imager (HRDI) and the Wind Imaging Interferometer (WINDII) instruments, which are both on the Upper Atmosphere Research Satellite, measure winds by sensing the Doppler shift in atmospheric emission features. Because the two observation sets are frequently nearly coincident in space and time, each provides a very effective validation test of the other. Discrepancies due to geophysical differences should be much smaller than for comparisons with other techniques (radars, rockets, etc.), and the very large sizes of the coincident data sets provide excellent statistics for the study. Issues that have been examined include relative systematic offsets and the wind magnitudes obtained with the two systems. A significant zero wind position difference of ∼6 m s −1 is identified for the zonal component, and it appears that this arises from an absolute perturbation in WINDII winds of -4 m s −1 and in HRDI of +2 m s −1 . Altitude offsets appear to be relatively small, and do not exceed 1 km. In addition, no evidence is found for the existence of a systematic wind speed bias between HRDI and WINDII. However, considerable day-to-day variability is found in the quality of the agreement, and RMS differences are surprisingly large, typically in the range of 20-30 m s −1 .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47857/1/585_1997_Article_70151089.pd

Zonal mean winds in the equatorial mesosphere and lower thermosphere observed by the High Resolution Doppler Imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94820/1/grl7281.pd

The High Resolution Doppler Imager (HRDI) on the Upper Atmosphere Research Satellite

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76425/1/AIAA-1993-123-305.pd

Global mesospheric tidal winds observed by the high resolution Doppler imager on board the Upper Atmosphere Research Satellite

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95326/1/grl6689.pd