The Dolmen Kolikho, Western Caucasus: Isotopic Investigation of Funeral Practice and Human Mobility

We investigated the dolmen known as Kolikho (Black Sea coast, Russia), discovered accidentally in 2008. It is a unique, undisturbed megalithic structure. The burial chamber contains disarticulated human remains from about 70 individuals. Radiocarbon dating shows that the dolmen was in use between roughly the 19th to 13th centuries BC. Strontium isotopes are used to investigate the origin and last residence location of the people buried in the structure.

Development of a Rapid Method for Monitoring Biodeterioration of Petroleum Products and Technical Fluids. Part I.

Abstract: Principles of a rapid method for monitoring biodeterioration of technicalfluids were developed with metalworking fluids as examples. Physicochemical andoperation properties of spent metalworking fluids were considered. The loss ofthe biological resistance of metalworking fluids leads to irreversible changesin the physicochemical and operation properties. A bank of test microorganismsrequired for validating the rapid method for monitoring biodeterioration wascompiled. © 2021, Pleiades Publishing, Ltd

Immunological monitoring for prediction of clinical response to antitumor vaccine therapy

Immunotherapy has shown promising results in a variety of cancers, including melanoma. However, the responses to therapy are usually heterogeneous, and understanding the factors affecting clinical outcome is still not achieved. Here, we show that immunological monitoring of the vaccine therapy for melanoma patients may help to predict the clinical course of the disease. We studied cytokine profile of cellular Th1 (IL-2, IL-12, IFN-γ) and humoral Th2 (IL-4, IL-10) immune response, vascular endothelial growth factor (VEGFA), transforming growth factor-β 2 (TGF-β 2), S100 protein (S100A1B and S100BB), adhesion molecule CD44 and serum cytokines β2-microglobulin to analyze different peripheral blood mononuclear cell subpopuations of patients treated with dendritic vaccines and/or cyclophosphamide in melanoma patients in the course of adjuvant treatment. The obtained data indicate predominance of cellular immunity in the first adjuvant group of patients with durable time to progression and shift to humoral with low cellular immunity in patients with short-term period to progression (increased levels of IL-4 and IL- 10). Beta-2 microglobulin was differentially expressed in adjuvant subgroups: its higher levels correlated with shorter progression-free survival and the total follow-up time. Immunoregulatory index was overall higher in patients with disease progression compared to the group of patients with no signs of disease progression. Copyright: Mikhaylova et al

Финансово-правовое регулирование обязательных платежей, уплачиваемых в федеральный бюджет Российской Федерации

В коллективной монографии рассматриваются актуальные проблемы, связанные с обязательными платежами неналогового характера, уплачиваемыми в федеральный бюджет Российской Федерации. Рассмотрены юридическая природа и критерии классификации обязательных платежей, уплачиваемых в федеральный бюджет Российской Федерации. Анализируются отдельные обязательные платежи, уплачиваемые в федеральный бюджет Российской Федерации. Законодательство приведено по состоянию на 1 июня 2017 г. Монография будет интересна для научных сотрудников, аспирантов, студентов бакалавриата и магистратуры, исследователей, специализирующихся в области финансовоправового регулирования