756 research outputs found
Embodying music theory: A performative approach
peer-reviewedBackground in embodied cognitive sciences and somatics applied to music
education/music theory. Western classical music theory is often taught in a way that is
disembodied from the performance of musical practices. This research aims to address this mind-body disconnect by utilising embodied cognition (Dewey, 1916, 1934, 1997, 2011; Schusterman, 2008; Bresler, 2013; Cox, 2016; Vass, E., & Deszpot, 2017) and somatic practice (Adler, 2002; Davis, 2007; Hartley, 1989; Hanlon-Johnson, 1995) to investigate and develop a unified and bodily approach to teaching and learning that is called a performative music theory approach. The experience of this performative approach towards teaching and learning Western classical music theory uses arts practice methods to capture the embodied understanding and perspective from the perspective of teacher and students during a performance based assignment. Reflective and reflexive practice (Schön, 1984; Howard, 2003; Westerlund, 2012; McLeod, 2017; Kolb, 1984; Smith, 2001) used by both the teacher and students provides insight into the embodied experiences and implications for teaching and learning during this performative music theory approach. This paper includes of one performance that was part of this arts practice PhD research project that demonstrates the performative music theory approach
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Neural and Psychological Coordination in Social Communication and Interaction
Dynamic, naturalistic study of social interactions in humans is a small but growing literature. Emerging from this work is the theory that social interaction creates a “merged mind” between interlocutors – they come into psychological, behavioral, and neural alignment in order to better predict each other and coordinate as one social unit. However social interaction is diverse, so more work is needed to understand the specific nature of alignment between people in a variety of interactive contexts. In particular, it’s unclear how heterogeneities among members of an interaction impact their ability to align. This work aims to help address this gap by first evaluating and improving ways to collect neuroimaging data in naturalistic, social settings (Chapter 2). Then, empirical research is presented that examines how personal similarity factors impact the extent of alignment during personal disclosure interactions, where one person speaks and the other listens (Chapter 3). Finally, further empirical research investigates different types of alignment that may be present in a dyadic back-and-forth discussion in a joint decision-making paradigm. How this work contributes to a broader understanding of the ways people communicate and work together, and how this research can continue with improved methods, is discussed
Investigation of an unusual metal-RNA cluster in the P5abc subdomain of the group I intron
This dissertation focuses on the spectroscopic and thermodynamic characterization of the unusual metal-RNA cluster found in the P5abc subdomain of the Tetrahymena group I intron. The P5abc subdomain is a part of the P4-P6 domain found in the Tetrahymena thermophila group I intron selfsplicing RNA. From both X-ray crystal structures of the P4-P6 domain, a remarkable cluster of Mg2+ or Mn2+ ions was found in the P5abc subdomain
(Cate et al. 1996; Juneau et al. 2001). It is believed that the metal ion core in the
P5abc subdomain stabilizes the active conformation of the RNA (Cate et al.
1996). An understanding of the role of these metal ions in facilitating the correct
structure of the P5abc subdomain provides insight into how metal ions help
overcome the folding barriers of complex RNA structures.
Under solution conditions, the properties of this uncommon metal ion core
and its influence on the truncated P5abc subdomain structure have been
investigated. Both EPR spectroscopy and thermal denaturation experiments
have been employed to search for a spectroscopic signature of metal ion core
formation and also determine the thermodynamic contribution of the metal ion
core on the stability of the folded P5abc structure.
A spectroscopic signature of metal ion core formation was assigned for
the P5abc subdomain by EPR microwave power saturation studies. Power
saturation studies of the P5abc subdomain, P4-P6 domain and corresponding
mutants reveal that the addition of 5 equivalents of Mn2+ are required for the wild type P5abc subdomain to form the metal ion core under solution conditions in 0.1 M NaCl. Results from both domain and subdomain microwave power saturation studies suggest that this technique can be applied for detecting
clustering of Mn2+ ions in other RNA structures.
The thermodynamic consequence of this metal ion core was probed by thermal denaturation techniques including UV-Vis spectroscopy and differential scanning calorimetry (DSC). DSC experiments were utilized to directly determine the thermodynamic contribution of the metal ion core. This value was determined to be an average of ∆∆G of -5.3 kcal/mol and is consistent with ∆∆G values obtained for other RNA tertiary structures
Investigation of an unusual metal-RNA cluster in the P5abc subdomain of the group I intron
This dissertation focuses on the spectroscopic and thermodynamic characterization of the unusual metal-RNA cluster found in the P5abc subdomain of the Tetrahymena group I intron. The P5abc subdomain is a part of the P4-P6 domain found in the Tetrahymena thermophila group I intron selfsplicing RNA. From both X-ray crystal structures of the P4-P6 domain, a remarkable cluster of Mg2+ or Mn2+ ions was found in the P5abc subdomain
(Cate et al. 1996; Juneau et al. 2001). It is believed that the metal ion core in the
P5abc subdomain stabilizes the active conformation of the RNA (Cate et al.
1996). An understanding of the role of these metal ions in facilitating the correct
structure of the P5abc subdomain provides insight into how metal ions help
overcome the folding barriers of complex RNA structures.
Under solution conditions, the properties of this uncommon metal ion core
and its influence on the truncated P5abc subdomain structure have been
investigated. Both EPR spectroscopy and thermal denaturation experiments
have been employed to search for a spectroscopic signature of metal ion core
formation and also determine the thermodynamic contribution of the metal ion
core on the stability of the folded P5abc structure.
A spectroscopic signature of metal ion core formation was assigned for
the P5abc subdomain by EPR microwave power saturation studies. Power
saturation studies of the P5abc subdomain, P4-P6 domain and corresponding
mutants reveal that the addition of 5 equivalents of Mn2+ are required for the wild type P5abc subdomain to form the metal ion core under solution conditions in 0.1 M NaCl. Results from both domain and subdomain microwave power saturation studies suggest that this technique can be applied for detecting
clustering of Mn2+ ions in other RNA structures.
The thermodynamic consequence of this metal ion core was probed by thermal denaturation techniques including UV-Vis spectroscopy and differential scanning calorimetry (DSC). DSC experiments were utilized to directly determine the thermodynamic contribution of the metal ion core. This value was determined to be an average of ∆∆G of -5.3 kcal/mol and is consistent with ∆∆G values obtained for other RNA tertiary structures
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Author Correction: Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper
Effects of caffeine supplementation on performance in ball games
Although a large body of evidence exists documenting the ergogenic properties of caffeine, most studies have focused on endurance performance. However, findings from endurance sports cannot be generalized to performance in ball games where, apart from having a high level of endurance, successful athletic performances require a combination of physiological, technical and cognitive capabilities. The purpose of this review was to critically evaluate studies that have examined the effect of a single dose of caffeine in isolation on one or more of the following performance measures: total distance, sprint performance, agility, vertical jump performance and accuracy in ball games. Searches of three major databases resulted in 19 studies (invasion games: 13; net-barrier games: 6) that evaluated the acute effects of caffeine on human participants, provided the caffeine dose administered, and included a ball games specific task or simulated match. Improvements in sprint performance were observed in 8 of 10 studies (80%), and vertical jump in 7 of 8 studies (88%). Equivocal results were reported for distance covered, agility and accuracy. Minor side effects were reported in 4 of 19 studies reviewed. Pre-exercise caffeine ingestion between 3.0 and 6.0 mg/kg of body mass appears to be a safe ergogenic aid for athletes in ball games. However, the efficacy of caffeine varies depending on various factors, including, but not limited to, the nature of the game, physical status and caffeine habituation. More research is warranted to clarify the effects of caffeine on performance measures unique to ball games, such as agility and accuracy. It is essential that athletes, coaches and practitioners evaluate the risk-benefit ratio of caffeine ingestion strategies on an individual case-by-case basis
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