Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age

Retrospective histologic analyses of bone biopsies and of post mortem samples from normal persons of different age groups, and of bone biopsies of age- and sex-matched groups of patients with primary osteoporosis and aplastic anemia show characteristic age dependent as well as pathologic changes including atrophy of osseous trabeculae and of hematopoiesis, and changes in the sinusoidal and arterial capillary compartments. These results indicate the possible role of a microvascular defect in the pathogenesis of osteoporosis and aplastic anemia

Recent BES measurements and the hadronic contribution to the QED vacuum polarization

We have updated our evaluation of the hadronic contribution to the running of the QED fine structure constant using the recent precise measurements of the e+e- annihilation at the center-of-mass (c.m.s.) energy region between 2.6 and 3.65 GeV performed by the BES collaboration. In the low energy region, around the rho resonance, we include the recent measurements from the BABAR, CDM-2, KLOE and SND collaborations. We obtain Delta alpha (5)_had (s) = 0.02750 +/- 0.00033 at s = m_Z^2.Comment: 3 pages, 1 figur

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions

ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions. In osteoarthritis (OA), ADAM15 is up-regulated in the chondrocytes already at early stages of cartilage degeneration where it seems to exert homeostatic effects likely associated with its ability to enhance integrin-mediated chondrocyte adhesion to the surrounding collagen matrix. The aim of our present study was, therefore, to characterize functional domains of ADAM15 involved in collagen II (CII) interaction and to analyse associated outside-in signalling events. Accordingly, ADAM15 and respective deletion mutants were stably transfected into the chondrocyte cell line T/C28a4. Transfected cells were adhered to CII and phosphoproteins analysed by Western blotting. Co-immunoprecipitation served to identify protein binding to ADAM15. Our results elucidate the prodomain as critical for the capacity of ADAM15 to enhance CII adhesion, thereby identifying for the first time a cell-adhesive role of a metalloproteinase prodomain. Moreover, the cytoplasmic tail of ADAM15 confers a modulatory effect on the autophosphorylation site Y397 of the focal adhesion kinase (FAK) during chondrocyte–collagen interaction. In conclusion, the newly uncovered impact of ADAM15 on signalling events that arise from chondrocyte interactions with its collagen matrix might contribute to the elucidation of the mechanism underlying its proposed chondroprotective role in degenerative cartilage disease

Partial survival and inelastic collapse for a randomly accelerated particle

We present an exact derivation of the survival probability of a randomly accelerated particle subject to partial absorption at the origin. We determine the persistence exponent and the amplitude associated to the decay of the survival probability at large times. For the problem of inelastic reflection at the origin, with coefficient of restitution $r$, we give a new derivation of the condition for inelastic collapse, $r<r_c=e^{-\pi/\sqrt{3}}$, and determine the persistence exponent exactly.Comment: 6 page

CLIC Muon Sweeper Design

There are several background sources which may affect the analysis of data and detector performans at the CLIC project. One of the important background source is halo muons, which are generated along the beam delivery system (BDS), for the detector performance. In order to reduce muon background, magnetized muon sweepers have been used as a shielding material that is already described in a previous study for CLIC [1]. The realistic muon sweeper has been designed with OPERA. The design parameters of muon sweeper have also been used to estimate muon background reduction with BDSIM Monte Carlo simulation code [2, 3].Comment: Talk presented at the International Workshop on Future Linear Colliders (LCWS15), Whistler, Canada, 2-6 November 2015, 7 pages, 6 figure