On the density-potential mapping in time-dependent density functional theory

The key questions of uniqueness and existence in time-dependent density functional theory are usually formulated only for potentials and densities that are analytic in time. Simple examples, standard in quantum mechanics, lead however to non-analyticities. We reformulate these questions in terms of a non-linear Schr\"odinger equation with a potential that depends non-locally on the wavefunction.Comment: 8 pages, 2 figure

R-matrix Floquet theory for laser-assisted electron-atom scattering

A new version of the R-matrix Floquet theory for laser-assisted electron-atom scattering is presented. The theory is non-perturbative and applicable to a non-relativistic many-electron atom or ion in a homogeneous linearly polarized field. It is based on the use of channel functions built from field-dressed target states, which greatly simplifies the general formalism.Comment: 18 pages, LaTeX2e, submitted to J.Phys.

Striking ethical balances: the contribution of ‘insider’ practitioner–academic social work research in England

Clinical-academics are well established and expanding in English health settings. However, despite growing evidence that research-active organisations improve service quality and outputs, research by social work practitioners remains relatively rare in social work practice in England other than as part of qualifying or post-qualifying study. In this context, the National Institute for Health and Care Research developed new funding streams to support the development of ‘practitioner–academics’, as an equivalent to clinical-academics in health settings. As early career practitioner–academics, who undertake research whilst remaining employed in our social work organisations, we present a case for practitioner–academic research, via two small research projects within our teams based on creative methods and focus groups. These projects illustrate the benefits of practitioner–academics in the knowledge production process, improving access to hard-to-reach research areas, developing swift rapport, which facilitates the production of rich and reliable data, and providing a novel means to navigate ethical issues including researcher positionality and research sensitivity. We also highlight challenges around informed consent, employee roles and researcher bias, including where practitioners are critical of practice within their service areas or are exposed to criticism themselves

Viral complementation allows HIV-1 replication without integration

<p>Abstract</p> <p>Background</p> <p>The integration of HIV-1 DNA into cellular chromatin is required for high levels of viral gene expression and for the production of new virions. However, the majority of HIV-1 DNA remains unintegrated and is generally considered a replicative dead-end. A limited amount of early gene expression from unintegrated DNA has been reported, but viral replication does not proceed further in cells which contain only unintegrated DNA. Multiple infection of cells is common, and cells that are productively infected with an integrated provirus frequently also contain unintegrated HIV-1 DNA. Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA).</p> <p>Results</p> <p>We employed reporter viruses and quantitative real time PCR to examine gene expression and virus replication during coinfection with integrating and non-integrating HIV-1. Most cells which contained only uDNA displayed no detected expression from fluorescent reporter genes inserted into early (Rev-independent) and late (Rev-dependent) locations in the HIV-1 genome. Coinfection with an integrated provirus resulted in a several fold increase in the number of cells displaying uDNA early gene expression and efficiently drove uDNA into late gene expression. We found that coinfection generates virions which package and deliver uDNA-derived genomes into cells; in this way uDNA completes its replication cycle by viral complementation. uDNA-derived genomes undergo recombination with the integrated provirus-derived genomes during second round infection.</p> <p>Conclusion</p> <p>This novel mode of retroviral replication allows survival of viruses which would otherwise be lost because of a failure to integrate, amplifies the effective amount of cellular coinfection, increases the replicating HIV-1 gene pool, and enhances the opportunity for diversification through errors of polymerization and recombination.</p

Terahertz photoconductivity and plasmon modes in double-quantum-well field-effect transistors

Double-quantum-well field-effect transistors with a grating gate exhibit a sharply resonant, voltage tuned terahertz photoconductivity. The voltage tuned resonance is determined by the plasma oscillations of the composite structure. The resonant photoconductivity requires a double-quantum well but the mechanism whereby plasma oscillations produce changes in device conductance is not understood. The phenomenon is potentially important for fast, tunable terahertz detectors

Trading-off payments and accuracy in online classification with paid stochastic experts

We investigate online classification with paid stochastic experts. Here, before making their prediction, each expert must be paid. The amount that we pay each expert directly influences the accuracy of their prediction through some unknown Lipschitz “productivity” function. In each round, the learner must decide how much to pay each expert and then make a prediction. They incur a cost equal to a weighted sum of the prediction error and upfront payments for all experts. We introduce an online learning algorithm whose total cost after T rounds exceeds that of a predictor which knows the productivity of all experts in advance by at most O(K2(lnT)T−−√) where K is the number of experts. In order to achieve this result, we combine Lipschitz bandits and online classification with surrogate losses. These tools allow us to improve upon the bound of order T2/3 one would obtain in the standard Lipschitz bandit setting. Our algorithm is empirically evaluated on synthetic data

The Hilbert-Schmidt Theorem Formulation of the R-Matrix Theory

Using the Hilbert-Schmidt theorem, we reformulate the R-matrix theory in terms of a uniformly and absolutely convergent expansion. Term by term differentiation is possible with this expansion in the neighborhood of the surface. Methods for improving the convergence are discussed when the R-function series is truncated for practical applications.Comment: 16 pages, Late