Organizing the Online Course

If you are new to online instruction or are a veteran looking for fresh ideas for designing your online courses, this presentation will demonstrate user-friendly design for online courses, including course menu links, instructions, content examples and tips for making the all-important first week of class work to make the whole semester more dynamic. Take away ideas to jump-start your course organization and create a meaningful learning experience for students

Mission-Centric Learning: Developing Students’ Workplace Readiness Skills

We discuss and evaluate the implementation of a mission-centric course project that is strategically tied to learning outcomes important to colleges of business. Specifically, to support our college’s mission, undergraduate students enrolled in a training and development class were tasked with applying course concepts to assess the need for, to design, and to deliver (to other business students) workplace readiness training. To aid other management educators interested in adopting similar strategically aligned and feedback-rich learning experiences, we outline and discuss relevant project planning, design, and facilitation issues, as well as present a summary of initial results derived from this project

Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner

AbstractHuntington's Disease (HD) is a neurodegenerative disorder that is defined by the accumulation of nanoscale aggregates comprised of the huntingtin (htt) protein. Aggregation is directly caused by an expanded polyglutamine (polyQ) domain in htt, leading to a diverse population of aggregate species, such as oligomers, fibrils, and annular aggregates. Furthermore, the length of this polyQ domain is directly related to onset and severity of disease. The first 17 N-terminal amino acids of htt have been shown to further modulate aggregation. Additionally, these 17 amino acids appear to have lipid binding properties as htt interacts with a variety of membrane-containing structures present in cells, such as organelles, and interactions with these membrane surfaces may further modulate htt aggregation. To investigate the interaction between htt exon1 and lipid bilayers, in situ atomic force microscopy (AFM) was used to directly monitor the aggregation of htt exon1 constructs with varying Q-lengths (35Q, 46Q, 51Q, and myc-53Q) on supported lipid membranes comprised of total brain lipid extract. The exon1 fragments accumulated on the lipid membranes, causing disruption of the membrane, in a polyQ dependent manner. Furthermore, the addition of an N-terminal myc-tag to the htt exon1 fragments impeded the interaction of htt with the bilayer

Measuring living standards with proxy variables

Very few demographic surveys in developing countries gather information on household income or consumption expenditure, despite the theoretical importance of these measures. Consequently, researchers have been forced to rely on ad hoc collections of proxy measures for living standards, and the properties of these proxies have not been systematically analyzed. In this research, we ask what hypotheses can be tested using proxy variables, and evaluate the performance of proxy measures in relation to consumption expenditures per adult, our preferred measure of living standards. We find that the proxy variables commonly employed in demographic research are very weak predictors of consumption per adult, having partial R^2 values that are extremely low. Nevertheless, when other factors are taken into account, we show that tests based on proxy variables are likely to be sufficiently powerful to merit consideration. In an examination of fertility, child mortality, and children’s schooling, we compare coefficient estimates based on consumption per adult to alternative estimates based on proxies, and find that the proxy-based estimates provide generally reliable guidance to the sign and magnitude of the preferred estimates

Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice

Abstract Background Selenoproteins contain selenocysteine (Sec), commonly considered the 21st genetically encoded amino acid. Many selenoproteins, such as the glutathione peroxidases and thioredoxin reductases, protect cells against oxidative stress by functioning as antioxidants and/or through their roles in the maintenance of intracellular redox balance. Since oxidative stress has been implicated in the pathogenesis of diabetic nephropathy, we hypothesized that selenoproteins protect against this complication of diabetes. Methods C57BL/6 mice that have a podocyte-specific inability to incorporate Sec into proteins (denoted in this paper as PodoTrsp-/-) and control mice were made diabetic by intraperitoneal injection of streptozotocin, or were injected with vehicle. Blood glucose, body weight, microalbuminuria, glomerular mesangial matrix expansion, and immunohistochemical markers of oxidative stress were assessed. Results After 3 and 6 months of diabetes, control and PodoTrsp-/- mice had similar levels of blood glucose. There were no differences in urinary albumin/creatinine ratios. Periodic acid-Schiff staining to examine mesangial matrix expansion also demonstrated no difference between control and PodoTrsp-/- mice after 6 months of diabetes, and there were no differences in immunohistochemical stainings for nitrotyrosine or NAD(P)H dehydrogenase, quinone 1. Conclusion Loss of podocyte selenoproteins in streptozotocin diabetic C57BL/6 mice does not lead to increased oxidative stress as assessed by nitrotyrosine and NAD(P)H dehydrogenase, quinone 1 immunostaining, nor does it lead to worsening nephropathy.http://deepblue.lib.umich.edu/bitstream/2027.42/112674/1/12882_2008_Article_98.pd

Health Status of Adult Montanans in Supported and Semi-Independent Living Arrangements

This study reports on the prevalence and severity of secondary conditions in adults with developmental disabilities living in 33 Montana counties. Secondary conditions are additional health problems acquired by an individual with a disability. Although the personal, social, and financial costs of these secondary conditions are extraordinarily high, they are frequently preventable. Ten of the top twelve secondary conditions reported by survey respondents involved issues that can be addressed by wellness activities or lifestyle management. In particular, survey ratings of “Communication,” “Weight,” and “Physical Fitness” problems suggest that these areas may contribute to other problems. Efforts to improve communication skills, nutrition, and fitness might prevent, or reduce the severity, of many other reported secondary conditions. Data suggesting that more than half of respondents are overweight and that a quarter of these are obese are particularly disturbing. Worthy goals for this population would be to increase exercise and fitness, improve nutrition, and reduce the prevalence of obesity

Phenotypic regional fMRI activation patterns during memory encoding in MCI and AD

Reliable blood-oxygen-level-dependent (BOLD) fMRI phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggregate examination of the functional neuroimaging research literature

Reefs at Risk: A Map-Based Indicator of Threats to the Worlds Coral Reefs

This report presents the first-ever detailed, map-based assessment of potential threats to coral reef ecosystems around the world. "Reefs at Risk" draws on 14 data sets (including maps of land cover, ports, settle-ments, and shipping lanes), information on 800 sites known to be degraded by people, and scientific expertise to model areas where reef degradation is predicted to occur, given existing human pressures on these areas. Results are an indicator of potential threat (risk), not a measure of actual condition. In some places, particularly where good management is practiced, reefs may be at risk but remain relatively healthy. In others, this indicator underestimates the degree to which reefs are threatened and degraded.Our results indicate that:Fifty-eight percent of the world's reefs are poten-tially threatened by human activity -- ranging from coastal development and destructive fishing practices to overexploitation of resources, marine pollution, and runoff from inland deforestation and farming.Coral reefs of Asia (Southeastern); the most species-rich on earth, are the most threatened of any region. More than 80 percent are at risk (undermedium and high potential threat), and over half are at high risk, primarily from coastal development and fishing-related pressures.Overexploitation and coastal development pose the greatest potential threat of the four risk categories considered in this study. Each, individually, affects a third of all reefs.The Pacific, which houses more reef area than any other region, is also the least threatened. About 60 percent of reefs here are at low risk.Outside of the Pacific, 70 percent of all reefs are at risk.At least 11 percent of the world's coral reefs contain high levels of reef fish biodiversity and are under high threat from human activities. These "hot spot" areas include almost all Philippine reefs, and coral communities off the coasts of Asia, the Comoros, and the Lesser Antilles in the Caribbean.Almost half a billion people -- 8 percent of the total global population -- live within 100 kilometers of a coral reef.Globally, more than 400 marine parks, sanctuaries, and reserves (marine protected areas) contain coral reefs. Most of these sites are very small -- more than 150 are under one square kilometer in size. At least 40 countries lack any marine protected areas for conserving their coral reef systems

Further alkaloids of Alstonia muelleriana

Five further alkaloids, des-N'a-methylanhydromacralstonine, quebrachidine, vinervinine, pleiocarpamine, and 2,7-dihydropleiocarpamine, have been isolated from Alstonia muelleriana bark. Phytochemical problems in the genus Alstonia are considered, especially with reference to the `macroline-derived' indole and bis-indole alkaloids.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33878/1/0000139.pd