Validating the National Survey of Student Engagement (NSSE) at a Research-Intensive University

The National Survey of Student Engagement (NSSE) has been used at universities across the U.S. and Canada to gather information about the quality of engagement of first-year students and graduating students. Institutions use NSSE’s five benchmarks of effective educational practice to compare themselves with other schools and to focus in on ways to improve the educational experiences of their students. However, studies indicate that these benchmarks may not be a valid way to convey NSSE information. This study was conducted to investigate whether or not NSSE’s five-factor model is the best fit for student engagement data collected at a large, public, research-intensive, land-grant university. The five-factor model did not fit the data for the 2008 sample of senior students at this university. Rather, a revised model using six factors instead of five and 21 of 42 items provided a more valid test blueprint. This new model was then tested and found to fit the 2011 sample of senior students at the same university. Discussion regarding use of a nationally collected data at an individual institution is provided

STEM Faculty Experiences with Students with Disabilities at a Land Grant Institution

Preparing faculty to meet the needs of the increasing number of students with disabilities is a critical need in higher education, particularly in the STEM (science, technology, engineering, and mathematics) fields. Quality preparation is an emerging problem as the number of higher education students with disabilities is on the rise. In this study, researchers used a qualitative methodology to examine STEM faculty members’ experiences with students with disabilities at a land grant institution in the southeastern United States. The study was conducted to answer the following questions: (a) What experiences, positive and negative, have STEM faculty members had working with students with disabilities?(b) How do STEM faculty members describe students with disabilities?, and (c) What resources do faculty members need to adequately serve students with disabilities? Five researchers conducted individual interviews with STEM faculty members. Interviews were transcribed and analyzed, with the following themes emerging from the data: Challenges, Support, Knowledge, Awareness/Visibility, and Formal versus Informal Accommodations. Implications from this study relate to the improvement of services for students with disabilities at higher education institutions and to the preparation of STEM faculty to accommodate their students

Modern optical astronomy: technology and impact of interferometry

The present `state of the art' and the path to future progress in high spatial resolution imaging interferometry is reviewed. The review begins with a treatment of the fundamentals of stellar optical interferometry, the origin, properties, optical effects of turbulence in the Earth's atmosphere, the passive methods that are applied on a single telescope to overcome atmospheric image degradation such as speckle interferometry, and various other techniques. These topics include differential speckle interferometry, speckle spectroscopy and polarimetry, phase diversity, wavefront shearing interferometry, phase-closure methods, dark speckle imaging, as well as the limitations imposed by the detectors on the performance of speckle imaging. A brief account is given of the technological innovation of adaptive-optics (AO) to compensate such atmospheric effects on the image in real time. A major advancement involves the transition from single-aperture to the dilute-aperture interferometry using multiple telescopes. Therefore, the review deals with recent developments involving ground-based, and space-based optical arrays. Emphasis is placed on the problems specific to delay-lines, beam recombination, polarization, dispersion, fringe-tracking, bootstrapping, coherencing and cophasing, and recovery of the visibility functions. The role of AO in enhancing visibilities is also discussed. The applications of interferometry, such as imaging, astrometry, and nulling are described. The mathematical intricacies of the various `post-detection' image-processing techniques are examined critically. The review concludes with a discussion of the astrophysical importance and the perspectives of interferometry.Comment: 65 pages LaTeX file including 23 figures. Reviews of Modern Physics, 2002, to appear in April issu

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

The human major histocompatibility complex (MHC) is contained within about 4 Mb on the short arm of chromosome 6 and is recognised as the most variable region in the human genome. The primary aim of the MHC Haplotype Project was to provide a comprehensively annotated reference sequence of a single, human leukocyte antigen-homozygous MHC haplotype and to use it as a basis against which variations could be assessed from seven other similarly homozygous cell lines, representative of the most common MHC haplotypes in the European population. Comparison of the haplotype sequences, including four haplotypes not previously analysed, resulted in the identification of >44,000 variations, both substitutions and indels (insertions and deletions), which have been submitted to the dbSNP database. The gene annotation uncovered haplotype-specific differences and confirmed the presence of more than 300 loci, including over 160 protein-coding genes. Combined analysis of the variation and annotation datasets revealed 122 gene loci with coding substitutions of which 97 were non-synonymous. The haplotype (A3-B7-DR15; PGF cell line) designated as the new MHC reference sequence, has been incorporated into the human genome assembly (NCBI35 and subsequent builds), and constitutes the largest single-haplotype sequence of the human genome to date. The extensive variation and annotation data derived from the analysis of seven further haplotypes have been made publicly available and provide a framework and resource for future association studies of all MHC-associated diseases and transplant medicine

Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

BACKGROUND: Ataxia telangiectasia-mutated and Rad3-related (ATR) is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. METHODS: ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD), haplotype analyses, and tagging SNP (tSNP) identification. Expression analyses were carried out using real-time PCR. RESULTS: The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. CONCLUSION: Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association studies. In addition, our study led to the characterization of a novel Δ33 splice form, which could generate a putative truncated protein lacking several functional domains. Additional studies in large cohorts and other populations will be needed to further evaluate if common and/or rare ATR sequence variants can be associated with a modest or intermediate breast cancer risk

Counselor competence with lesbian, gay, and bisexual clients: Differences among practice settings

Counselors from school and community practice, counseling students, and counselor educators (N= 468) participated in this study of competence to serve lesbian, gay, and bisexual (LGB) clients. Participants reported high LGB-affirmative attitudes but lower knowledge and skills. School counselors reported significantly lower LGB competence than did counselors in other settings. Implications include the importance of graduate and postgraduate training to improve LGB knowledge and skills and the hope that LGB-affirmative attitudes suggest receptivity toward such growth. Consejeros que trabajan en prácticas escolares y de comunidad, estudiantes de consejería y educadores de consejería (N= 468) participaron en este estudio sobre la competencia para servir a clientes lesbianas, gays y bisexuales (LGB). Los participantes comunicaron un nivel elevado de actitudes afirmativas hacia LGB, pero menores conocimientos y habilidades. Los consejeros escolares indicaron niveles de competencia en LGB significativamente menores que los consejeros en otros escenarios. Las implicaciones incluyen la importancia de la formaciõn de estudiantes de grado y posgrado para mejorar sus conocimientos y habilidades sobre LGB y la esperanza de que las actitudes afirmativas hacia LGB sugieren receptividad hacia dicha formaciõn