Crown Size-Arch Space Relationships During Human Prenatal Dental Development

As shown in composite reconstructions made from optically-projected measurements of 10μ frontal maxillofacial sections of 20 histologically normal fetuses and embryos in the 70-255 mm CRL range, individual differences in relative tooth size and interdental spacing are evident by 10.5-11 weeks of gestation, and age-corrected crown-size correlations (r=0.40) approximate those in postnatal life. Despite an eight-fold increase in crown dimensions, interdental spacing remains approximately constant after 150 mm CRL, suggesting that the tooth organs or the periodontal membranes are able to maintain spacing, into the third trimester.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67036/2/10.1177_00220345790580020301.pd

Sagittal Growth of the Nasomaxillary Complex during the Second Trimester of Human Prenatal Development

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66545/2/10.1177_00220345650440010401.pd

Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans

The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various factors. Differences in muscle function between the two species could be crucial but often have been overlooked. The purpose of this study was to evaluate and compare muscle excursions in walking between mice and humans

Organ Weight Patterns in Human Fetal Development

Previous studies have reported regression formulae describing organ weight changes in often circumscribed time periods of human prenatal development. This study reports regression formulae characterizing growth in ten selected fetal organs relative to changing organ weight in 80 singleton abortuses assessed as being morphologically normal or typical-for-age, and representing weeks 13-31 (fertilization age) of pregnancy. Correlation analyses suggest that total fetal body weight or brain weight may be better reference parameters against which to assess increasing organ weights during much of the fetal period. Fetal body weight rather than the commonly used crown-rump length or menstrual age is the best reference parameter for assessing either growth of a single organ or in the generation of regression formulae. Of the ten organs monitored, the analyses of this study indicate that changes in brain weight are most highly correlated with changes in either crown-rump length or total fetal body weight. Organ weight correlations become of particular significance in the understanding of defect clusters involving organs seen in birth defect syndromes

Effect of Experimental Surgery on Mandibular Growth in Syrian Hamsters

Enucleation of the incisor germinal center and extraction of molars in the mandibles of young hamsters produced a significant decrease in the size of the mandibular body, loss of normal occlusion, and a shift of the mandibular body medially and cranially. Condylectomies mainly affected the length of the mandible and were closely related to loss of the articular cartilage and impairment of ramal growth.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67643/2/10.1177_00220345710500024001.pd