Coffee, please?: Sociolinguistic influences on politeness strategies in making requests

In this paper I look at the extent to which factors of gender and context influence linguistic features such as hedging and syntax in indirect requests. I analyzed different features of indirect speech used by participants. I selected a few scenarios that focused on different social aspects where requests would be needed. Responses from men and women were compared to see if the gender of the speaker had any effect on the linguistic features used

Frozen in Time? Exploring Faith-based Admission Standards in Christian Higher Education

Low enrollment is a significant problem in small Christian liberal arts colleges. It is my position that addressing the adaptive challenge of organizational identity will create an inclusive, accessible, and relevant faith-based college community which appeals to applicants and thereby grow enrollment. Drawing on process organization theory, situated learning theory, and adaptive leadership theory, I propose in this organizational improvement plan a change process enacted by a community of practice to foster sensemaking about organizational identity through college admissions work. This plan identifies portfolio-based admissions and critical policy analysis as ways to invite applicants to demonstrate their strengths; the approaches honour individual faith practice and foster a sense of belonging during the admissions process. The community of practice advances continuous improvement and innovation in the change implementation plan and creates space for varying degrees of stakeholder change readiness in the process

SUPPLY RESPONSE TO TECHNOLOGICAL CHANGE AND REGULATION: THE CASE OF MECHANICALLY DEBONED POULTRY

Research and Development/Tech Change/Emerging Technologies,

Marketing New England poultry, Station Bulletin, no.483

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

Effective Use of Slaughter Checks for Identification and Control of Swine Disease

Swine producers, individually and as an industry are faced with numerous and complicated challenges. It is a\u3e dynamic industi^^,. .One area of interaction within tiie infrast^cture-is that of.animal health.^lere are m^ny. diseases known to affect swihe and their production efficiencies,, These diseases Impact producers and the industry in numerous, interrelated ways ., Severe animal disease can cause producers•to dramatically limit or even halt,production [1]. Disease can be clinical or subclinical.. Clinical disease is easily observable and actions can be taken to reduce its level; However, many swine diseases are subclinical and are riot visually observableFor subclinical disease, detection and accurate diagnoses in the live animal can be difficult.;-,.Yet these diseases can result in significant reductions in\u27animal efficiency and.^roduqef, losse

Marketing New England poultry, Station Bulletin, no.475

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

Determination of Swine Pneumonia and Impacts on Production Costs Through Slaughter Checks

Livestock producers are continually faced with decisions on animal health maintenance. Surveillance*of animals for disease symptoms enables producers to more successfully deal with these events and effectively evaluate disease prevention and treatment programs

Marketing New England poultry, Station Bulletin, no.482

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

Marketing New England poultry, Station Bulletin, no.484

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

Genomic instability is a key hallmark of cancer leading to tumour heterogeneity and therapeutic resistance. ​BRCA2 has a fundamental role in error-free DNA repair but also sustains genome integrity by promoting ​RAD51 nucleofilament formation at stalled replication forks. ​CDK2 phosphorylates ​BRCA2 (pS3291-​BRCA2) to limit stabilizing contacts with polymerized ​RAD51; however, how replication stress modulates ​CDK2 activity and whether loss of pS3291-​BRCA2 regulation results in genomic instability of tumours are not known. Here we demonstrate that the Hippo pathway kinase ​LATS1 interacts with ​CDK2 in response to genotoxic stress to constrain pS3291-​BRCA2 and support ​RAD51 nucleofilaments, thereby maintaining genomic fidelity during replication stalling. We also show that ​LATS1 forms part of an ​ATR-mediated response to replication stress that requires the tumour suppressor ​RASSF1A. Importantly, perturbation of the ​ATR–​RASSF1A–​LATS1 signalling axis leads to genomic defects associated with loss of ​BRCA2 function and contributes to genomic instability and ‘BRCA-ness’ in lung cancers