Minor physical anomalies and neurological soft signs in patients with schizophrenia and their siblings

Neurological soft soft signs (NSSs) and minor physical anomalies (MPAs) are consistently found at higher rates in individuals with schizophrenia compared to healthy controls. However, limited research has been conducted on these traits among the biological relatives of these patients. We aimed to identify the possible origins of these traits in schizophrenia by exploring them in patients with schizophrenia, their healthy siblings and normal controls. Ninety-six patients with schizophrenia, their 66 non-psychotic siblings and 52 healthy subjects were studied. Measures included the Neurological Evaluation Scale, a structured examination for detection of minor physical anomalies, stroop and verbal fluency tests for cognitive assessment, and scales for assessment of disease severity in patients; the Scale for the Assesment of Negative Symptoms and the Scale for the Assesment of Positive Symptoms. Increased rates of NSSs and high MPA scores were found in both the patients and their siblings as compared to normal controls. MPAs in several body regions were similar (eyes, ears, hands and feet) or correlated (innercanthal width and head circumference) between patients and their respective siblings. However, there was little similarity in palate and tongue anomalies between these subjects. These results suggest that NSSs and MPAs might represent two distinct markers of risk for schizophrenia. MPAs at different locations may also represent distinct pathological processes, such that palate and tongue abnormalities are more likely to represent non-familial rather than familial factors compared to other abnormalities. (C) 2011 Elsevier Ireland Ltd. All rights reserved

Reducing Mental Illness Stigma in Mental Health Professionals Using a Web-based Approach

Objective: This study was designed to investigate the efficacy of a web-based mental disorder stigma education program for mental health professionals. Methods: The sample consisted of 205 individuals who were either residents or specialists in psychiatry. Participants were contacted through a national web-based e-mail group that consisted of professionals in psychiatry, who were randomly assigned to experimental and control groups. The experimental group received an informative e-mail which contained a general account of "stigma" before they were asked to respond to an Internet-based questionnaire which was designed to predict their stigmatizing attitudes towards individuals with mental disorders. Control subjects, on the other hand, were asked to respond to the same Internet-based questionnaire without having been given the aforementioned informative e-mail. Results: The experimental group, compared to the control group, demonstrated a lesser stigmatizing attitude towards individuals with mental illness, as measured by the Internet-based survey which utilized the "social distance" concepts of stigma. Conclusions: These data suggest that such "anti-stigma" campaigns using the potential of the Internet might be an effective tool in the fight against the stigmatization of persons with mental illness

Impairment of Executive Functions and Memory in Unaffected Siblings of Patients with Bipolar Disorder

Objective: Neurocognitive impairments in bipolar patients as a possible endophenotype is a growing field of research. Impairments in executive functions and memory have been reported in relatives of patients with bipolar disorder, suggesting that they could be potential endophenotypes for genetic studies. In this study, neuropsychological performance in unaffected siblings of patients diagnosed as bipolar I disorder is compared to that of matched healthy controls

The impact of cognitive impairment, neurological soft signs and subdepressive symptoms on functional outcome in bipolar disorder

Background: Cognitive impairments and subsyndromal depressive symptoms are present during euthymic periods of bipolar disorder (BD). Most studies have determined that cognitive impairments and residual depressive symptoms have major impacts on psychosocial functioning. The aim of the present study was to identify the major factor responsible for low psychosocial functioning in a subgroup of patients with BD despite clinical recovery

The psychological state and changes in the routine of the patients with rheumatic diseases during the coronavirus disease (COVID-19) outbreak in Turkey: a web-based cross-sectional survey

We hypothesized that patients with rheumatic diseases (RD) would have increased psychological distress during the COVID-19 outbreak; therefore, assessed their psychological symptoms and changes in their routine. A web-based questionnaire survey was conducted in a cross-sectional design in three groups of participants: (1.) patients with RD, (2.) hospital workers, and (3.) high-school teachers/academic staff. Psychiatric status was evaluated using Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised scale. Overall response rate was 34.7%. We studied 771 patients with RD, 535 hospital workers, and 917 teachers/academic staff. Most of the patients with RD were unwilling to go to the hospital (86%), while 22% discontinued their medications. Biological DMARDS were the most frequent drugs whose doses were altered. Only 4% were willing to take hydroxychloroquine for protection. Moreover, the frequency of anxiety (20%), depression (43%), and post-traumatic stress (28%) among patients with RD were found to be comparable to that found among the teachers/academic staff (23%, 43% and 29%, respectively), whereas significantly less than that observed among the hospital workers (40%, 62%, and 46%, respectively) (p < 0.001). Female gender, use of social media, having a comorbid disease, or a psychiatric disorder were found to be independently associated with psychiatric symptoms in total study population. The majority of the patients were unwilling to attend outpatient visits and one-fifth skipped or stopped their immunosuppressive agents. Psychiatric symptoms in patient's and teacher's populations were of considerable clinical concern, despite being significantly lower than that observed among the hospital workers