2 research outputs found
Manipulating thyroid status alters endoplasmic reticulum calcium homeostasis in rat cerebellum
7-18Thyroid-related
hormones regulate the efficiency and expression of sarco-endoplasmic reticulum
calcium ATPases in cardiac and skeletal muscle. However, little is known about
the relationship between thyroid hormones and calcium (Ca2+)
homeostasis in the brain. It is hypothesized that manipulating rat thyroid
hormone levels would induce significant brain Ca2+ adaptations
consistent with clinical findings. Adult male Sprague-Dawley rats were assigned
to one of three treatment groups for 28 days: control, hypothyroid
(6-n-propyl-2-thiouracil (PTU), an inhibitor of thyroxine (T4) synthesis), and
hyperthyroid (T4). Throughout, rats were given weekly behavioral tests. Ca2+
accumulation decreased in the cerebellum in both hyper- and hypothyroid
animals. This was specific to different ER pools of calcium with regional
heterogeneity in the response to thyroid hormone manipulation. Behavioral tasks
demonstrated sensitivity to thyroid manipulation, and corresponded to
alterations in calcium homeostasis. Ca2+ accumulation heterogeneity
in chronic hyper- and hypothyroid animals potentially explains clinical
manifestations of altered thyroid status