Event generation for beam dump experiments

A wealth of new physics models which are motivated by questions such as the nature of dark matter, the origin of the neutrino masses and the baryon asymmetry in the universe, predict the existence of hidden sectors featuring new particles. Among the possibilities are heavy neutral leptons, vectors and scalars, that feebly interact with the Standard Model (SM) sector and are typically light and long lived. Such new states could be produced in high-intensity facilities, the so-called beam dump experiments, either directly in the hard interaction or as a decay product of heavier mesons. They could then decay back to the SM or to hidden sector particles, giving rise to peculiar decay or interaction signatures in a far-placed detector. Simulating such kind of events presents a challenge, as not only short-distance new physics (hard production, hadron decays, and interaction with the detector) and usual SM phenomena need to be described but also the travel has to be accounted for as determined by the geometry of the detector. In this work, we describe a new plugin to the {\sc MadGraph5\_aMC@NLO} platform, which allows the complete simulation of new physics processes relevant for beam dump experiments, including the various mechanisms for the production of hidden particles, namely their decays or scattering off SM particles, as well as their far detection, keeping into account spatial correlations and the geometry of the experiment.Comment: LaTeX, 42 pages, 14 figure

Causality and momentum conservation from relative locality

Theories with a curved momentum space, which became recently of interest in the quantum-gravity literature, can in general violate many apparently robust aspects of our current description of the laws of physics, including relativistic invariance, locality, causality and global momentum conservation. We here explore some aspects of the particularly severe pathologies arising in generic theories with curved momentum space for what concerns causality and momentum conservation. However, we also report results suggesting that when momentum space is maximally symmetric, and the theory is formulated (DSR-)relativistically, with the associated relativity of spacetime locality, momentum is globally conserved and there is no violation of causality.Comment: 20 pages, 6 figures, latex (V2: minor editing

The qTq_T subtraction method: electroweak corrections and power suppressed contributions

Building upon the formulation of transverse-momentum resummation for heavy-quark hadroproduction, we present the first application of the $q_T$ subtraction formalism to the computation of electroweak corrections to massive lepton pairs through the Drell-Yan mechanism. We then study the power suppressed contributions to the $q_T$ subtraction formula in the parameter $r_{cut}$, defined as the minimum transverse momentum of the lepton pair normalised to its invariant mass. We analytically compute the leading power correction from initial and final-state radiation to the inclusive cross section. In the case of initial-state radiation the power correction is quadratic in $r_{cut}$ and our analytic result is consistent with results previously obtained in the literature. Final-state radiation produces linear contributions in $r_{cut}$ that may challenge the efficiency of the $q_T$ subtraction procedure. We explicitly compute the linear power correction in the case of the inclusive cross section and we discuss the extension of our calculation to differential distributions.Comment: LaTeX, 22 pages, 4 figure

Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata)

T-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8αα dimer and MHC-I, and, successively, we simulated the CD8αα/MHC-I complex. Finally, the 3D structure of the CD8/MHC-I/TCR complex was simulated in order to investigate the possible changes that can influence TCR signalling events.L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com

Mixed QCD-electroweak corrections to pp→lνl+X at the LHC

We consider the hadroproduction of a massive charged lepton plus the corresponding neutrino through the Drell-Yan mechanism. We present a new computation of the mixed QCD-electroweak (EW) corrections to this process. The cancellation of soft and collinear singularities is achieved by using a formulation of the qT subtraction formalism derived from the next-to-next-to-leading-order QCD calculation for heavy-quark production. For the first time, all the real and virtual contributions due to initial- and final-state radiation are consistently included without any approximation, except for the finite part of the two-loop virtual correction, which is computed in the pole approximation and suitably improved through a reweighting procedure. We demonstrate that our calculation is reliable in both on-shell and off-shell regions, thereby providing the first prediction of the mixed QCD-EW corrections in the entire region of the lepton transverse momentum. The computed corrections are in qualitative agreement with what we obtain in a factorized approach of QCD and EW corrections. At large values of the lepton pT, the mixed QCD-EW corrections are negative and increase in size, to about −20% with respect to the next-to-leading-order QCD result at pT=500  GeV

Analysis of the expression and modulation of selected immune-related gene transcripts in the DLEC cell line from European sea bass (Dicentrarchus labrax)

Cell lines have been established from different fish species especially for virus isolation and for studying cell-pathogen interactions, and therefore are of interest in aquaculture. In this paper, we have investigated the presence and the regulation of some immune genes in the DLEC (Dicentrarchus labrax embryonic cells) cell line from European sea bass (Dicentrarchus labrax L.) to preliminary elucidate their action. The basal expression of the selected genes (interleukin- 1β (IL-1β), cyclooxygenase-2 (COX-2), transforming growth factor-β (TGF-β), CD8-α, major histocompatibility complex II-β (MHC II-β), interferon (IFN) and Mx protein (Mx)) have been investigated and, successively, their modulation have been studied both after stimulation with different mitogen agents and after a transfection with a sequence codifying for the coat protein of a fish nervous necrosis virus (NNV). The results have evidenced that the inflammatory molecules (IL-1β, COX-2, TGF-β), constitutively expressed by the DLEC cell line, are not up-regulated by the stimulation with lipopolysaccharide (LPS) from E. coli, whether the expression of the T-cell marker transcripts (CD8-α, MHC II-β) is influenced by the action of a lectin from Phaseolus vulgaris (PHA-L). Finally, the expression of the coat NNV protein in the DLEC cell line, after the transfection, led to an high up-regulation of IFN and Mx gene transcripts. These data suggest that the DLEC cell line recognize specific pathogen-associated molecular patterns (PAMPs) and, therefore, could be useful for studying T-cell pathways and viral responses in sea bass avoiding the use of live test animals