The prehospital quick SOFA score is associated with in-hospital mortality in noninfected patients: A retrospective, cross-sectional study.

This study aimed to determine the accuracy of the quick Sequential Organ Failure Assessment (qSOFA) score in predicting mortality among prehospital patients with and without infection. This single-center, retrospective, cross-sectional study was conducted among patients who arrived via the emergency medical services (EMS). We calculated the qSOFA score and Modified Early Warning Score (MEWS) from prehospital records. We identified patients as infected if they received intravenous antibiotics at the emergency department or within the first 24 hours. Receiver operating characteristic analysis was used to evaluate and compare the performance of the qSOFA score, each physiological parameter, and the MEWS in predicting admission and in-hospital mortality in patients with and without infection. Multivariate analysis was used to evaluate the qSOFA score and other risk factors. Out of 1574 prehospital patients, 47.1% were admitted and 3.2% died in the hospital. The performance of the qSOFA score in predicting in-hospital mortality in noninfected patients was 0.70, higher than for each parameter and the MEWS. The areas under the curve for the qSOFA+ model vs. the qSOFA- model was 0.77 vs. 0.68 for noninfected patients (p <0.05) and 0.71 vs. 0.68 for infected patients (p = 0.41). The likelihood ratio test comparing the qSOFA- and qSOFA+ groups demonstrated significant improvement for noninfected patients (p <0.01). Multivariate regression analysis for in-hospital mortality demonstrated that the qSOFA score is an independent prognosticator for in-hospital mortality, especially among noninfected patients (odds ratio, 3.60; p <0.01). In conclusion, the prehospital qSOFA score was associated with in-hospital mortality in noninfected patients and may be a beneficial tool for identifying deteriorating patients in the prehospital setting

Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71837/1/j.1356-9597.2004.00711.x.pd

<i>Cha</i>-<i>Koji</i>, comprising green tea leaves fermented with <i>Aspergillus luchuensis var kawachii kitahara</i>, increases regulatory T cell production in mice and humans

<p>Green tea leaves fermented with <i>Aspergillus luchuensis var kawachii kitahara</i> (<i>Cha</i>-<i>Koji</i>) are a health food containing live <i>A. luchuensis</i>. In this study, we examined the effects of <i>Cha</i>-<i>Koji</i> on the immune system and the enteric environment. First, we designed a clinical trial; after ingesting <i>Cha</i>-<i>Koji</i> daily for 28 days, blood parameters and the fecal composition of the participants were analyzed. Similarly, mice were administered (oral administration) with <i>Cha</i>-<i>Koji</i> suspension or its vehicle for 14 days. Thereafter, both humans and mice were examined by analyzing their immune cell phenotypes and intestinal microbiota. Regulatory T cell (Treg) numbers were significantly increased after administering <i>Cha</i>-<i>Koji</i>. An increase of <i>Clostridium</i> subcluster XIVa, that were known to be rich in butyrate-producing bacterium, was observed in human feces, but not in mice. These results suggest that <i>Cha</i>-<i>Koji</i> has the ability to increase Treg production in both humans and mice, irrespective of the presence of enteric butyrate.</p> <p>“<i>Cha</i>-<i>Koji</i>” increases regulatory T cells in mice and humans.</p