Book review : What else can a teacher do? Review your career, reduce stress and gain control of your life / David Hodgson

Review of Hodgson, D (2017) 'What else can a teacher do? Review your career, reduce stress and gain control of your life'. Crown House Publishing

Managing the inshore marine environment in the marineand coastal access act era: The Welsh experience

Fellow Authors, Lewis, K. (Aberystwyth University) and Bullimore, B. ( Marine Environmental Consultant)This study investigated the Welsh Government’s approach to inshore fisheries management since commencement of the provisions in the 2009 Marine and Coastal Access Act (MCAA), including the centralisation of management within the Welsh Government rather than establishing a successor to the long established Sea Fisheries Committees, and the impact of the Welsh Government’s approach from the perspective of key stakeholders.The Report concludes that the experience of centralising marine and fisheries management in Wales has failed to produce the benefits claimed by its proponents before the implementation of the 2009 MCAA

Schizophrenia and the progression of emotional expression in relation to others

Gaining an improved understanding of people diagnosed with schizophrenia has the potential to influence priorities for therapy. Psychosis is commonly understood through the perspective of the medical model. However, the experience of social context surrounding psychosis is not well understood. In this research project we used a phenomenological methodology with a longitudinal design to interview 7 participants across a 12-month period to understand the social experiences surrounding psychosis. Eleven themes were explicated and divided into two phases of the illness experience: (a) transition into emotional shutdown included the experiences of not being acknowledged, relational confusion, not being expressive, detachment, reliving the past, and having no sense of direction; and (b) recovery from emotional shutdown included the experiences of being acknowledged, expression, resolution, independence, and a sense of direction. The experiential themes provide clinicians with new insights to better assess vulnerability, and have the potential to inform goals for therapy

In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma.

INTRODUCTION Intratumoral injections of novel therapeutics can activate tumor antigen-specific T cells for locoregional tumor control and may even induce durable systemic protection (against distant metastases) via recirculating T cells. Here we explored the possibility of a universal immunotherapy that promotes T-cell responses in situ and beyond, upon intratumoral injection of nanoparticles formulated with micron-sized crystals. METHODS Cucumber mosaic virus-like particles containing a tetanus toxin peptide (CuMVTT) were formulated with microcrystalline tyrosine (MCT) adjuvant and injected directly in B16F10 melanoma tumors. To further enhance immunogenicity, we loaded the nanoparticles with a TLR7/8 ligand and incorporated a universal tetanus toxin T-helper cell peptide. We assessed therapeutic efficacy and induction of local and systemic immune responses, including RNA sequencing, providing broad insight into the tumor microenvironment and correlates of protection. RESULTS MCT crystals were successfully decorated with CuMVTT nanoparticles. This 'immune-enhancer' formed immunogenic depots in injected tumors, enhanced polyfunctional CD8+ and CD4+ T cells, and inhibited B16F10 tumor growth locally and systemically. Local inflammation and immune responses were associated with upregulation of genes involved in complement activation and collagen formation. CONCLUSIONS Our new immune-enhancer turned immunologically cold tumors into hot ones and inhibited local and distant tumor growth. This type of immunotherapy does not require the identification of (patient-individual) relevant tumor antigens. It is well tolerated, non-infectious, and affordable, and can readily be upscaled for future clinical testing and broad application in melanoma and likely other solid tumors

Book review: Debates in the digital humanities, M.K Gold & L.F Klein (Eds.)

Review of Debates in the Digital Humanities (2016), M.K Gold & L.F Klein (Eds.) University of Minnesota Pres

Review of 'Metadata' (2016) by Marcia Lei Zeng and Jian Qin

Review of 'Metadata' by Marcia Lei Zeng and Jian Qin. Published by Facet Publishing in 2016

'No-nonsense guide to training in libraries' by Barbara Allen : review

book reviewReview of 'No-nonsense guide to training in libraries' by Barbara Allen. Facet, 201

'Research methods in information' (2nd edition) by Alison Jane Pickard : review

Review of 'Research Methods in Information' (2nd edition) by Alison Jane Pickard. Facet, 201

Book review: Chowdhury, G., Ruthven, I. (eds) (2015) 'Cultural heritage information: access and management'.

Cultural Heritage Information: Access and Management Ian Ruthven & G.G. Chowdhury (Eds.) Facet, 2015 Review by Alan Bullimor