891 research outputs found
Player retention in league of legends: A study using survival analysis
© 2018 ACM. Multi-player online esports games are designed for extended durations of play, requiring substantial experience to master. Furthermore, esports game revenues are increasingly driven by in-game purchases. For esports companies, the trends in players leaving their games therefore not only provide information about potential problems in the user experience, but also impacts revenue. Being able to predict when players are about to leave the game-churn prediction-is therefore an important solution for companies in the rapidly growing esports sector, as this allows them to take action to remedy churn problems. The objective of the work presented here is to understand the impact of specific behavioral characteristics on the likelihood of a player continuing to play the esports title League of Legends. Here, a solution to the problem is presented based on the application of survival analysis, using Mixed Effects Cox Regression, to predict player churn. Survival Analysis forms a useful approach for the churn prediction problem as it provides rates as well as an assessment of the characteristics of players who are at risk of leaving the game. Hazard rates are also presented for the leading indicators, with results showing that duration between matches played is a strong indicator of potential churn
Cross-Entropy Method for Design and Optimization of Pixelated Metasurfaces
© 2013 IEEE. Electromagnetic metasurfaces are planar two-dimensional metamaterials, typically of subwavelength thickness. Unit cell elements of different shapes have been widely explored, including electric and magnetic dipoles, patches, arbitrary geometries and pixelated surfaces. Although pixelated metasurfaces have a great advantage of geometric versatility, their design and analysis requires algorithmic approach. One of the techniques for their design is via evolutionary simulation-driven optimization. Since full-wave electromagnetic simulations are time-consuming, optimization methods with fast convergence properties are preferable. In this article, we demonstrate the application of the cross-entropy optimization method to design of artificial magnetic conductors (AMCs) and thin printed phase shifters. Single-frequency AMCs at 10 GHz (X band) and dual-frequency AMCs at 8 and 12 GHz (X and Ku band) were produced that are more manufacturing-friendly, and thus cost effective, than previously reported AMCs. We also show that phase-shifting unit cells with transmission magnitudes over 0.9 (linear) can be designed using the proposed optimization technique. Other potential applications of these unit cells are in phase-correcting and beam-steering metasurfaces
Perceived Utility of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Seattle International Brain Injury Consensus Conference Consensus-Based Analysis and Recommendations
Intracranial pressure; Brain injury; ConsensusPresión intracraneal; Lesión cerebral; ConsensoPressió intracranial; Lesió cerebral; ConsensBACKGROUND:
Intracranial pressure (ICP) monitoring is widely practiced, but the indications are incompletely developed, and guidelines are poorly followed.
OBJECTIVE:
To study the monitoring practices of an established expert panel (the clinical working group from the Seattle International Brain Injury Consensus Conference effort) to examine the match between monitoring guidelines and their clinical decision-making and offer guidance for clinicians considering monitor insertion.
METHODS:
We polled the 42 Seattle International Brain Injury Consensus Conference panel members' ICP monitoring decisions for virtual patients, using matrices of presenting signs (Glasgow Coma Scale [GCS] total or GCS motor, pupillary examination, and computed tomography diagnosis). Monitor insertion decisions were yes, no, or unsure (traffic light approach). We analyzed their responses for weighting of the presenting signs in decision-making using univariate regression.
RESULTS:
Heatmaps constructed from the choices of 41 panel members revealed wider ICP monitor use than predicted by guidelines. Clinical examination (GCS) was by far the most important characteristic and differed from guidelines in being nonlinear. The modified Marshall computed tomography classification was second and pupils third. We constructed a heatmap and listed the main clinical determinants representing 80% ICP monitor insertion consensus for our recommendations.
CONCLUSION:
Candidacy for ICP monitoring exceeds published indicators for monitor insertion, suggesting the clinical perception that the value of ICP data is greater than simply detecting and monitoring severe intracranial hypertension. Monitor insertion heatmaps are offered as potential guidance for ICP monitor insertion and to stimulate research into what actually drives monitor insertion in unconstrained, real-world conditions
A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
Brain injury; Head trauma; AlgorithmDaño cerebral; Trauma en la cabeza; AlgoritmoLesió cerebral; Trauma al cap; AlgoritmeBackground: Management algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation’s sTBI Management Guidelines, as they were not evidence-based. Methods: We used a Delphi-method-based consensus approach to address management of sTBI patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active sTBI specialists from six continents comprised the panel. Eight surveys iterated queries and comments. An in-person meeting included whole- and small-group discussions and blinded voting. Consensus required 80% agreement. We developed heatmaps based on a traffic-light model where panelists’ decision tendencies were the focus of recommendations. Results: We provide comprehensive algorithms for ICP-monitor-based adult sTBI management. Consensus established 18 interventions as fundamental and ten treatments not to be used. We provide a three-tier algorithm for treating elevated ICP. Treatments within a tier are considered empirically equivalent. Higher tiers involve higher risk therapies. Tiers 1, 2, and 3 include 10, 4, and 3 interventions, respectively. We include inter-tier considerations, and recommendations for critical neuroworsening to assist the recognition and treatment of declining patients. Novel elements include guidance for autoregulation-based ICP treatment based on MAP Challenge results, and two heatmaps to guide (1) ICP-monitor removal and (2) consideration of sedation holidays for neurological examination. Conclusions: Our modern and comprehensive sTBI-management protocol is designed to assist clinicians managing sTBI patients monitored with ICP-monitors alone. Consensus-based (class III evidence), it provides management recommendations based on combined expert opinion. It reflects neither a standard-of-care nor a substitute for thoughtful individualized management.We thank our financial supporters who include Adler/Geirsch Attorney at Law, the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Neurotrauma and Critical Care, Bard, the Brain Trauma Foundation, DePuy, Hemedex, Integra, the Neurointensive Care Section of the European Society of Intensive Care Medicine, Neurosurgical Society of Australasia, Medtronic, Moberg Research, Natus, Neuroptics, Raumedic, Sophysa, Stryker, and Zoll
Submillimeter observations of IRAS and WISE debris disk candidates
A set of six debris disk candidates identified with IRAS or WISE excesses were observed at either 350 μm or 450 μm with the Caltech Submillimeter Observatory. Five of the targets – HIP 51658, HIP 68160, HIP 73512, HIP 76375, and HIP 112460 – have among the largest measured excess emission from cold dust from IRAS in the 25–100 μm bands. Single temperature blackbody fits to the excess dust emission of these sources predict 350–450 μm fluxes above 240 mJy. The final target – HIP 73165 – exhibits weak excess emission above the stellar photosphere from WISE measurements at 22 μm, indicative of a population of warm circumstellar dust. None of the six targets were detected, with 3σ upper limits ranging from 51–239 mJy. These limits are significantly below the expected fluxes from SED fitting. Two potential causes of the null detections were explored – companion stars and contamination. To investigate the possible influence of companion stars, imaging data were analyzed from new adaptive optics data from the ARIES instrument on the 6.5 m MMT and archival HST, Gemini NIRI, and POSS/2MASS data. The images are sensitive to all stellar companions beyond a radius of 1–94 AU, with the inner limit depending on the distance and brightness of each target. One target is identified as a binary system, but with a separation too large to impact the disk. While the gravitational effects of a companion do not appear to provide an explanation for the submm upper limits, the majority of the IRAS excess targets show evidence for contaminating sources, based on investigation of higher resolution WISE and archival Spitzer and Herschel images. Finally, the exploratory submm measurements of the WISE excess source suggest that the hot dust present around these targets is not matched by a comparable population of colder, outer dust. More extensive and more sensitive Herschel observations of WISE excess sources will build upon this initial example to further define the characteristics of warm debris disks sources
Two-photon quantum walks in an elliptical direct-write waveguide array
Integrated optics provides an ideal test bed for the emulation of quantum
systems via continuous-time quantum walks. Here we study the evolution of
two-photon states in an elliptic array of waveguides. We characterise the
photonic chip via coherent-light tomography and use the results to predict
distinct differences between temporally indistinguishable and distinguishable
two-photon inputs which we then compare with experimental observations. Our
work highlights the feasibility for emulation of coherent quantum phenomena in
three-dimensional waveguide structures.Comment: 8 pages, 7 figure
A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
An Evaluability Assessment of the West Virginia Physical Activity Plan, 2015: Lessons Learned for Other State Physical Activity Plans
Background
The US National Physical Activity Plan (NPAP) was released in 2009 as a national strategic plan to increase physical activity (PA). The NPAP emphasized implementing state and local PA pro- grams. Dissemination of information about NPAP has been lim- ited, however.
Community Context
West Virginia is a predominantly rural state with high rates of chronic diseases associated with physical inactivity. In 2015 an evaluability assessment (EA) of the West Virginia Physical Activ- ity Plan (WVPAP) was conducted, and community stakeholders were invited to participate in updating the plan.
Methods
A good EA seeks stakeholder input, assists in identifying program areas that need improvement, and ensures that a full evaluation will produce useful information. Data for this EA were collected via national stakeholder interviews, document reviews, discussions among workgroups consisting of state and local stakehold- ers, and surveys to determine how well the WVPAP had been im- plemented.
Outcome
The EA highlighted the need for WVPAP leaders to 1) establish a specific entity to implement local PA plans, 2) create sector-spe- cific logic models to simplify the WVPAP for local stakeholders, 3) evaluate the PA plan’s implementation frequently from the out- set, 4) use quick and efficient engagement techniques with stake- holders when working with them to select strategies, tactics, and measurable outcomes, and 5) understand the elements necessary to implement, manage, and evaluate a good PA plan.
Interpretation
An EA process is recommended for other leaders of PA plans. Our project highlights the stakeholders’ desire to simplify the WVPAP so that it can be set up as a locally driven process that engages communities in implementation
Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds.
Environmental chemicals with estrogenic activities have been suggested to be associated with deleterious effects in animals and humans. To characterize estrogenic chemicals and their mechanisms of action, we established in vitro and cell culture assays that detect human estrogen receptor [alpha] (hER[alpha])-mediated estrogenicity. First, we assayed chemicals to determine their ability to modulate direct interaction between the hER[alpha] and the steroid receptor coactivator-1 (SRC-1) and in a competition binding assay to displace 17ss-estradiol (E(2)). Second, we tested the chemicals for estrogen-associated transcriptional activity in the yeast estrogen screen and in the estrogen-responsive MCF-7 human breast cancer cell line. The chemicals investigated in this study were o,p'-DDT (racemic mixture and enantiomers), nonylphenol mixture (NPm), and two poorly analyzed compounds in the environment, namely, tris-4-(chlorophenyl)methane (Tris-H) and tris-4-(chlorophenyl)methanol (Tris-OH). In both yeast and MCF-7 cells, we determined estrogenic activity via the estrogen receptor (ER) for o,p'-DDT, NPm, and for the very first time, Tris-H and Tris-OH. However, unlike estrogens, none of these xenobiotics seemed to be able to induce ER/SRC-1 interactions, most likely because the conformation of the activated receptor would not allow direct contacts with this coactivator. However, these compounds were able to inhibit [(3)H]-E(2) binding to hER, which reveals a direct interaction with the receptor. In conclusion, the test compounds are estrogen mimics, but their molecular mechanism of action appears to be different from that of the natural hormone as revealed by the receptor/coactivator interaction analysis
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