Istraživački pristup za formiranje nove tipologije teorije prostornog planiranja

What is being suggested in this paper is the research approach for the classification of theoretical contributions in the scientific domain of the spatial planning. Typology is a multidimensional classification, actually it is the framework for the understanding of the subject area, theory and practice, ideas and methodologies. The complex approach is needed to organize the complex and diverse domain of spatial planning theory, which has been shaped by different schools of thought and the influences of the related scientific disciplines. It has been suggested that the research approach becomes the bridge between two cultures, in other words it should be the synthesis of the qualitative and quantitative methods of the typology construction. With the analysis of the existing typologies, which are quantitatively derived, the chosen concepts will be improved and completed due to the computerized statistical analysis of the appropriate bibliometrical data. Moreover, the procedure in the opposite direction will be used, which also connects empiric types with their conceptual counterparts. With that approach, the main aim is to achieve the comprehensive classification scheme, which will take part of the platform for integration of the interdisciplinary approach in the spatial planning domain. That concept of the research belongs to the wider approach that has got the aim that with the scientific innovations and imaginations bring about the solving of the problems and challenges that the spatial planning faces with. The forming of the new typology is the first step in that direction.U ovom radu predlaže se istraživački pristup za sistematizaciju znanja i klasifikovanje teorijskih doprinosa u naučnoj oblasti prostornog planiranja. Tipologija predstavlja višedimenzionalnu klasifikaciju, odnosno okvir za razumevanje predmetne oblasti, teorije i prakse, ideja i metodologija. Složeni pristup je potreban da bi se uredila kompleksna i raznovrsna oblast teorije prostornog planiranja, koju su oblikovale različite škole razmišljanja i uticaji iz srodnih naučnih disciplina. Predlaže se da istraživački pristup bude most između dve kulture, odnosno sinteza kvalitativnog i kvantitativnog metoda formiranja tipologija. Putem analize postojećih tipologija, koje su kvantitativno izvedene, izabrani koncepti će se unaprediti i dopuniti kroz kompjuterizovanu statističku analizu odgovarajućih bibliometrijskih podataka. Koristiće se i procedura u suprotnom smeru, koja takođe povezuje empirijske tipove sa njihovim konceptualnim ekvivalentima. Cilj je da se takvim pristupom dobije sveobuhvatna klasifikaciona šema, koja će imati ulogu platforme za integraciju interdisciplinarnog pristupa prostornom planiranju

Impact of genetics on neoadjuvant therapy with complete pathological response in metastatic colorectal cancer: case report and review of the literature

Treatment of colorectal metastatic cancer is still challenging, despite recent improvements in chemotherapy. A genetic cancer profile, such as the KRAS (Kirsten rat sarcoma) gene status, plays a key role in individualized tailored therapy. Molecular targeted therapy added to neoadjuvant chemotherapy can achieve a better pathological response and prolong survival. Pathological complete response of colorectal cancer stage N is rare. A 47-year-old female patient presented with rectal adenocarcinoma and three liver metastases (cT3d/4, N2, M1). After seven cycles of Bevacizumab and CAPOX in neoadjuvant setting, we noted more than 70.0% regression of metastases and complete regression of the primary tumor. We performed low anterior resection of rectum and synchronous subsegmental resection of S3, because the other two lesions were not detectable. Pathology revealed complete response of the primary and also secondary tumors. After 8 months, diagnostic tests did not show any sign of recurrence and the remaining liver lesions disappeared. Colorectal cancer is a heterogeneous disease and it is necessary to identify patients who are at-risk of recurrence and suitable for neoadjuvant therapy. Genetic biomarkers play an important role in metastatic colorectal cancer treatment. Because of the mutated KRAS gene, Bevacizumab was added to cytotoxic therapy achieving a complete pathological response of primary tumor and metastasis. This case is unique because all reported cases with similar results, described staged surgery and one of reverse staged surgery, but with similar results. This neoadjuvant therapy has extra ordinary results for colorectal cancer stage IV and can help disease-free and long-term survival