254 research outputs found
Structure of the merozoite surface protein 1 from Plasmodium falciparum
The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading Plasmodium merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in Plasmodium infection and immunity
Quantum Smoluchowski equation: Escape from a metastable state
We develop a quantum Smoluchowski equation in terms of a true probability
distribution function to describe quantum Brownian motion in configuration
space in large friction limit at arbitrary temperature and derive the rate of
barrier crossing and tunneling within an unified scheme. The present treatment
is independent of path integral formalism and is based on canonical
quantization procedure.Comment: 10 pages, To appear in the Proceedings of Statphys - Kolkata I
Ukrainian refugees in Germany: Escape, arrival and everyday life
Die gemeinsame Kurzstudie des Instituts für Arbeitsmarkt- und Berufsforschung (IAB), des Bundesinstituts für Bevölkerungsforschung (BiB), des Forschungszentrums des Bundesamtes für Migration und Flüchtlinge (BAMF-FZ) und des Sozio-oekonomischen Panels (SOEP) am DIW Berlin stellt die ersten zentralen Befunde aus der gemeinsamen Studie "Geflüchtete aus der Ukraine in Deutschland" vor. Im Fokus der bundesweiten Studie stehen die Lebensumstände und die damit verbundenen zentralen Unterstützungsbedarfe der ukrainischen Geflüchteten in Deutschland.The short study by the Institute for Employment Research (IAB), the Federal Institute for Population Research (BiB), the Research Centre of the Federal Office for Migration and Refugees (BAMF-FZ) and the Socio-Economic Panel (SOEP) at the German Institute for Economic Research (DIW Berlin) presents the first key findings from the joint study "Refugees from Ukraine in Germany". The focus of the nationwide study is on the living conditions and the associated central support needs of Ukrainian refugees in Germany
Rational Design of a Plasmid Origin That Replicates Efficiently in Both Gram-Positive and Gram-Negative Bacteria
Background: Most plasmids replicate only within a particular genus or family
GeflĂĽchtete aus der Ukraine in Deutschland: Flucht, Ankunft und Leben
Die gemeinsame Kurzstudie des Instituts für Arbeitsmarkt- und Berufsforschung (IAB), des Bundesinstituts für Bevölkerungsforschung (BiB), des Forschungszentrums des Bundesamtes für Migration und Flüchtlinge (BAMF-FZ) und des Sozio-oekonomischen Panels (SOEP) am DIW Berlin stellt die ersten zentralen Befunde aus der gemeinsamen Studie "Geflüchtete aus der Ukraine in Deutschland" vor. Im Fokus der bundesweiten Studie stehen die Lebensumstände und die damit verbundenen zentralen Unterstützungsbedarfe der ukrainischen Geflüchteten in Deutschland.The short study by the Institute for Employment Research (IAB), the Federal Institute for Population Research (BiB), the Research Centre of the Federal Office for Migration and Refugees (BAMF-FZ) and the Socio-Economic Panel (SOEP) at the German Institute for Economic Research (DIW Berlin) presents the first key findings from the joint study "Refugees from Ukraine in Germany". The focus of the nationwide study is on the living conditions and the associated central support needs of Ukrainian refugees in Germany
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