Distribution of phylogenetical lineages vs. demographic characteristics of patients and cities of isolation.

<p>Distribution of phylogenetical lineages vs. demographic characteristics of patients and cities of isolation.</p

Descriptive statistics on age of patients in this study.

<p>Descriptive statistics on age of patients in this study.</p

A minimum spanning tree (MST) illustrating evolutionary relationships between <i>M</i>. <i>tuberculosis</i> spoligotypes.

<p>MST constructed on all isolates including the orphan patterns (n = 293) in function of various characteristics. (<b>A</b>)MST based on phylogenetical lineages; (<b>B</b>) MST based on cities of isolation; and (<b>C</b>) MST based on HIV serology. The phylogenetic tree connects each genotype based on degree of changes required to go from one allele to another. The structure of the tree is represented by branches (continuous vs. dashed and dotted lines) and circles representing each individual pattern. Note that the length of the branches represents the distance between patterns while the complexity of the lines (continuous, gray dashed and gray dotted) denotes the number of allele/spacer changes between two patterns: solid lines, 1 or 2 or more changes (thicker ones indicate a single change, while the thinner one indicate 2 changes); gray dashed lines represent 3 changes; and gray dotted lines represent 4 or more changes. The size of the circle is proportional to the total number of isolates in our study, illustrating unique isolates (smaller nodes) versus clustered isolates (bigger nodes). The color of the circles indicates the phylogenetic lineage to which the specific pattern belongs.</p

Distribution of Spoligotype International Types (SIT) in this study.

<p>Distribution of Spoligotype International Types (SIT) in this study.</p

Distribution of lineages/sublineages of isolates from Tanzania (n = 293).

<p>Distribution of lineages/sublineages of isolates from Tanzania (n = 293).</p