Methods of improvement of forecasting of development of mineral deposits' power supply

Mineral deposits (among which non-ferrous metals take a leading place) are situated on the territory of our planet rather unevenly, and often in out-of-the-way places. Nuclear power (particularly, transportable nuclear power plants) provides the new possibilities of power supply, which is very important for deposits' development. This article shares the economic aspects of forecasting in the field of power development (in particular, nuclear power on the basis of transportable nuclear power plants). Economic barriers of development of innovative nuclear technologies are considered on the example of transportable nuclear power plants. At the same time, there are given the ways of elimination of such barrier to development of this technology as methodical absence of investigation of a question of distribution of added cost between producers of innovative equipment and final product. Addition of new analytical tool (“business diagonal”) is offered for a method of definition of economically efficient distribution of added cost (received as a result of introduction of innovative technologies) between participants of production and consumption of atomic energy within the “economic cross” model. There is offered the order of use of method of cash flows discounting at calculations between nuclear market participants. Economic methods, offered in this article, may be used in forecasting of development of other energy technologies and introduction of prospective energy equipment

Quaternary <i>N</i>‑(2-Pyridyl)-DABCO Salts: One-Pot in Situ Formation from Pyridine‑<i>N</i>‑oxides and Reactions with Nucleophiles: A Mild and Selective Route to Substituted <i>N</i>‑(2-Pyridyl)‑<i>N</i>′‑ethylpiperazines

The <i>N</i>-(2-pyridyl)-<i>N</i>′-ethylpiperazines are important structural motifs in several medicinally relevant compounds. Known synthetic methods toward these structures are multistep and generally based on the S_NAr-chemistry; their applicability is significantly limited to substrates containing electron-withdrawing groups. Here, we describe a new methodology for a rapid and modular access to this privileged scaffold. Importantly, the developed protocol proved to be very general and efficient for the substrates containing substituents of different electronic nature. An operationally simple, metal-free, one-pot synthetic procedure involves the initial reaction of activated heterocyclic <i>N</i>-oxides with DABCO, followed by in situ treatment of the resultant quaternary <i>N</i>-(2-pyridyl)-DABCO salts with nucleophiles, resulting in ring-opening. The method features mild reaction conditions, high positional selectivity, and excellent functional-group tolerance. The utility of our approach is demonstrated by the late-stage site-selective functionalizations of complex molecules; a rapid modular assembly of MC2050, a potent PARP-1 inhibitor; and gram-scale preparations