Lateral frontal cortex volume reduction in Tourette syndrome revealed by VBM

<p>Abstract</p> <p>Background</p> <p>Structural changes have been found predominantly in the frontal cortex and in the striatum in children and adolescents with Gilles de la Tourette syndrome (GTS). The influence of comorbid symptomatology is unclear. Here we sought to address the question of gray matter abnormalities in GTS patients <it>with </it>co-morbid obsessive-compulsive disorder (OCD) and/or attention deficit hyperactivity disorder (ADHD) using voxel-based morphometry (VBM) in twenty-nine adult actually unmedicated GTS patients and twenty-five healthy control subjects.</p> <p>Results</p> <p>In GTS we detected a cluster of decreased gray matter volume in the left inferior frontal gyrus (IFG), but no regions demonstrating volume increases. By comparing subgroups of GTS with comorbid ADHD to the subgroup with comorbid OCD, we found a left-sided amygdalar volume increase.</p> <p>Conclusions</p> <p>From our results it is suggested that the left IFG may constitute a common underlying structural correlate of GTS with co-morbid OCD/ADHD. A volume reduction in this brain region that has been previously identified as a key region in OCD and was associated with the active inhibition of attentional processes may reflect the failure to control behavior. Amygdala volume increase is discussed on the background of a linkage of this structure with ADHD symptomatology. Correlations with clinical data revealed gray matter volume changes in specific brain areas that have been described in these conditions each.</p

Ontogeny of juvenile freshwater pearl mussels, Margaritifera margaritifera (Bivalvia: Margaritiferidae).

The gills of juvenile freshwater bivalves undergo a complex morphogenesis that may correlate with changes in feeding ecology, but ontogenic studies on juvenile mussels are rare. Scanning electron microscopy was used to examine the ultrastructure and ontogeny of 117 juvenile freshwater pearl mussels (Margaritifera margaritifera) ranging in age from 1–44 months and length from 0.49–8.90 mm. Three stages of gill development are described. In Stage 1 (5–9 inner demibranch filaments), only unreflected inner demibranch filaments were present. In Stage 2 (9–17 inner demibranch filaments), inner demibranch filaments began to reflect when shell length exceeded 1.13 mm, at 13–16 months old. Reflection began in medial filaments and then proceeded anterior and posterior. In Stage 3 (28–94 inner demibranch filaments), outer demibranch filaments began developing at shell length > 3.1 mm and about 34 months of age. The oral groove on the inner demibranch was first observed in 34 month old specimens > 2.66 mm but was never observed on the outer demibranch. Shell length (R2 = 0.99) was a better predictor of developmental stage compared to age (R2 = 0.84). The full suite of gill ciliation was present on filaments in all stages. Interfilamentary distance averaged 31.3 μm and did not change with age (4–44 months) or with size (0.75–8.9 mm). Distance between laterofrontal cirri couplets averaged 1.54 μm and did not change significantly with size or age. Labial palp primordia were present in even the youngest individuals but ciliature became more diverse in more developed individuals. Information presented here is valuable to captive rearing programmes as it provides insight in to when juveniles may be particularly vulnerable to stressors due to specific ontogenic changes. The data are compared with two other recent studies of Margaritifera development.N/

Volatiles in magmas related to the Campanian Ignimbrite eruption. Experiments vs. natural findings

The solubility of H2O- and CO2-bearing fluids in trachytic and trachybasaltic melts from erupted magmas of the Campi Flegrei Volcanic District has been investigated experimentally at 1100 and 1200 °C, respectively, and at 100, 200, 300, 400, and 500 MPa. The solubility of H2O in the investigated melts varies between 3.48 ± 0.07 wt% at 100 MPa to 10.76 ± 0.12 wt% at 500 MPa in trachytic melts and from 3.49 ± 0.07 wt% at 100 MPa to 9.10 ± 0.11 wt% at 500 MPa in trachybasaltic melts. The content of dissolved CO2 in melts coexisting with the most CO2-rich fluid phase increases from 281 ± 24 ppm at 100 MPa to 2710 ± 99 ppm at 500 MPa in trachyte, and from 727 ± 102 ppm at 100 MPa to 3565 ± 111 ppm at 500 MPa in trachybasalt. Natural samples from the Campanian Ignimbrite eruption (trachyte) and from the Solchiaro eruption (trachybasalt) were collected around the city of Naples and on Procida Island. Deuterium/hydrogen (D/H) ratios were analyzed in natural pumices pre-heated at different temperatures to remove water adsorbed and/or imprinted by glass alteration processes. It has been determined that heating of the glass to 350 °C efficiently removes most of secondary water and the remaining concentrations represent primary magmatic water preserved in the erupted material. Hydrogen isotope composition (with δD values ranging between -70‰ and -110‰) and its correlation with bulk water content in selected pumice samples of the Campanian Ignimbrite eruption are consistent with isotopic fractionation between magmatic fluid and melt during degassing of erupting magma. Hence, the H2O and CO2 contents in natural glasses from pumice samples are considered as minimum estimates on volatile concentrations in the melt just prior to the eruption or at the fragmentation event. The water contents in natural glasses vary from 0.83 ± 0.07 to 3.74 ± 0.06 wt% for trachytes from the Campanian Ignimbrite eruption and from 1.96 ± 0.06 to 3.47 ± 0.07 wt% for trachybasalts from the Solchiaro eruption. The CO2 contents vary from 78 ± 120 ppm CO2 to 1743 ± 274 ppm for trachytes from the Campanian Ignimbrite eruption and from 240 ± 293 to 1213 ± 250 ppm for trachybasalts from the Solchiaro eruption. A combination of natural and experimental data provides minimum pressure estimates for the storage and ascent conditions of magmas. The Campanian Ignimbrite magma could have been stored or ponded during its rising path at two different levels: a deeper one corresponding to depth of about 8 to 15 km and a shallower one at about 1 to 8 km. Trachybasalts from Solchiaro erupted from the deepest level of about 11 km with a storage or ponding level at around 2 to 8 km depth. Although an uncertainty of at least a kilometer has to be considered in estimating storage or ponding depths, these estimates point to significantly deeper magmatic sources for both eruptions as those considered previously