9 research outputs found
Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase
No full textA series of isothiazole dioxides was synthesized and evaluated as inhibitors of protein farnesyltransferase from the parasite that causes African sleeping sickness (Trypanosoma brucei). The most potent compound in the series inhibited the parasite enzyme with an IC50 of 2 \u3bcM and blocked the growth of the bloodstream parasite in vitro with an ED50 of 10 \u3bcM. The same compound inhibited rat protein farnesyltransferase and protein geranylgeranyltransferase type I only at much higher concentration. \ua9 2002 Elsevier Science Ltd. All rights reserved
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
No full text10.1371/journal.pntd.0002775PLoS Neglected Tropical Diseases84e277
Role of peripherally infused angiotensin II on the human hypothalamic–pituitary–adrenal axis
No full textEffects of Recombinant Human Erythropoietin on the Plasma Levels of Vasoactive Regulatory Peptides in Patients on Maintenance Hemodialysis
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Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking
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