XMM-Newton, Chandra, and CGPS observations of the Supernova Remnants G85.4+0.7 and G85.9-0.6

We present an XMM-Newton detection of two low radio surface brightness SNRs, G85.4+0.7 and G85.9-0.6, discovered with the Canadian Galactic Plane Survey (CGPS). High-resolution XMM-Newton images revealing the morphology of the diffuse emission, as well as discrete point sources, are presented and correlated with radio and Chandra images. The new data also permit a spectroscopic analysis of the diffuse emission regions, and a spectroscopic and timing analysis of the point sources. Distances have been determined from HI and CO data to be 3.5 +/- 1.0 kpc for SNR G85.4+0.7 and 4.8 +/- 1.6 kpc for SNR G85.9-0.6. The SNR G85.4+0.7 is found to have a temperature of ~12-13 MK and a 0.5-2.5 keV luminosity of ~1-4 x 10^33 D(3.5)^2 erg/s (where D(3.5) is the distance in units of 3.5 kpc), with an electron density n_e of ~0.07-0.16(fD(3.5))^-1/2 cm^-3 (where f is the volume filling factor), and a shock age of ~9-49(fD(3.5))^1/2 kyr. The SNR G85.9-0.6 is found to have a temperature of ~15-19 MK and a 0.5-2.5 keV luminosity of ~1-4 x 10^34 D(4.8)^2 erg/s (where D(4.8) is the distance in units of 4.8 kpc), with an electron density n_e of ~0.04-0.10(fD(4.8))^-1/2 cm^-3 and a shock age of ~12-42(fD(4.8))^1/2 kyr. Based on the data presented here, none of the point sources appears to be the neutron star associated with either SNR.Comment: 30 pages using emulateapj, 16 figures with quality reduced for astro-ph only. The original version with high-resolution figures can be downloaded from: http://www.physics.umanitoba.ca/~samar/astro-ph/G85s-ms09102007.pdf To appear in ApJ (Jan 20 2008 issue, v673, n1

Lung tumour markers in oncology practice: a study of TPA and CA125

Several substances mark the course of lung cancer and may reliably help the clinician in decision-making. This is the first clinical study specifically designed to compare tissue polypeptide antigen and CA 125 tumour associated antigen. Three hundred and eighty-four new lung cancer patients (309 males) were studied at their first clinical presentation and then strictly followed-up. Anthropometric, clinical and laboratory data – including tissue polypeptide antigen and CA 125 tumour associated antigen serum levels – were prospectively recorded. A total of 1000 tissue polypeptide antigen and CA 125 tumour associated antigen serum assays (384 pre-treatment and 616 posttreatment assays) were performed. Both tissue polypeptide antigen and CA 125 tumour associated antigen correlated significantly with the T, N and M stage descriptors at diagnosis (Rho: 0.200, 0.203, 0.263 and 0.181, 0.240, 0.276, respectively), and then with the objective response to treatment (Rho: 0.388 and 0.207, respectively). A pleural neoplastic involvement was mainly associated to an increase of CA 125 tumour associated antigen (Rho: 0.397). Both tissue polypeptide antigen and CA 125 tumour associated antigen were strongly predictive of the patients' outcome, as assessed by the univariate analysis of survival (log-rank test: 37.24 and 29.01) and several Cox' proportional hazards regression models. The two marker tests are similarly helpful and appear complementary, given the low inter-marker correlation and their independent prognostic capability

Periodic Modulations in an X-ray Flare from Sagittarius A*

We present the highly significant detection of a quasi-periodic flux modulation with a period of 22.2 min seen in the X-ray data of the Sgr A* flare of 2004 August 31. This flaring event, which lasted a total of about three hours, was detected simultaneously by EPIC on XMM-Newton and the NICMOS near-infrared camera on the HST. Given the inherent difficulty in, and the lack of readily available methods for quantifying the probability of a periodic signal detected over only several cycles in a data set where red noise can be important, we developed a general method for quantifying the likelihood that such a modulation is indeed intrinsic to the source and does not arise from background fluctuations. We here describe this Monte Carlo based method, and discuss the results obtained by its application to a other XMM-Newton data sets. Under the simplest hypothesis that we witnessed a transient event that evolved, peaked and decayed near the marginally stable orbit of the supermassive black hole, this result implies that for a mass of 3.5 x 10^{6} Msun, the central object must have an angular momentum corresponding to a spin parameter of a=0.22.Comment: 4 pages, 6 figures, submitted to ApJ

Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome

Objective The aim of this study was to evaluate over time circulating γδ T lymphocytes in melanoma patients in terms of frequency, effector functions, and relationship with clinical stage and evolution, by comparing preoperative values to those obtained at a mean follow-up of 36 months or in the event of recurrence or disease progression, and to those of healthy controls. Also, we correlated the presence of tumor-infiltrating γδ T lymphocytes with clinical evolution of melanoma. Results Mean frequencies of circulating γδ T cells before and after melanoma removal were very similar and comparable to healthy subjects, but patients who progressed to stage III or IV showed a significantly decreased frequency of circulating Vγ9Vδ2 T cells. The distribution of Vγ9Vδ2 memory and effector subsets was similar in healthy subjects and melanoma patients at diagnosis, but circulating γδ T cells of patients after melanoma removal had a skewed terminally-differentiated effector memory phenotype. Highly suggestive of progressive differentiation toward a cytotoxic phenotype, Vγ9Vδ2T cells from patients at follow up had increased cytotoxic potential and limited cytokine production capability, while the opposite pattern was detected in Vγ9Vδ2T cells from patients before melanoma removal. Conclusions Follow-up data also showed that tumor infiltrating γδ T cells were significantly associated with lower mortality and relapse rates, suggesting that they may serve as a prognostic biomarker, for human melanom

XMM-Newton discovery of 2.6 s pulsations in the soft gamma-ray repeater SGR 1627-41

After nearly a decade of quiescence, the soft gamma-ray repeater SGR 1627-41 reactivated on 2008 May 28 with a bursting episode followed by a slowly decaying enhancement of its persistent emission. To search for the still unknown spin period of this SGR taking advantage of its high flux state, we performed on 2008 September 27-28 a 120 ks long X-ray observation with the XMM-Newton satellite. Pulsations with P = 2.594578(6) s were detected at a higher than 6-sigma confidence level, with a double-peaked pulse profile. The pulsed fraction in the 2-12 keV range is 19% +/- 3% and 24% +/- 3% for the fundamental and the second harmonic, respectively. The observed 2-10 keV flux is 3.4E-13 erg/cm^2/s, still a factor of ~ 5 above the quiescent pre-burst-activation level, and the spectrum is well fitted by an absorbed power law plus blackbody model (photon index Gamma = 0.6, blackbody temperature kT = 0.5 keV, and absorption nH = 1.2E+23 cm^-2). We also detected a shell of diffuse soft X-ray emission which is likely associated with the young supernova remnant G337.0-0.1.Comment: Minor changes to match the final version (to appear in The Astrophysical Journal Letters). 5 pages in emulate-apj style, 1 table, 4 figures (1 color

Probing the Pulsar Wind Nebula of PSR B0355+54

We present XMM-Newton and Chandra X-ray observations of the middle-aged radio pulsar PSR B0355+54. Our X-ray observations reveal emission not only from the pulsar itself, but also from a compact diffuse component extending ~50'' in the opposite direction to the pulsar's proper motion. There is also evidence for the presence of fainter diffuse emission extending ~5' from the point source. The compact diffuse feature is well-fitted with a power-law, the index of which is consistent with the values found for other pulsar wind nebulae. The morphology of the diffuse component is similar to the ram-pressure confined pulsar wind nebulae detected for other sources. The X-ray emission from the pulsar itself is described well by a thermal plus power-law fit, with the thermal emission most likely originating in a hot polar cap.Comment: 9 pages (uses emulateapj.cls), 8 figures, 2 tables, accepted for publication in Ap

Knowledge, attitudes and self-reported practices of food service staff in nursing homes and long-term care facilities

The aim of this study was to investigate knowledge, attitudes and practices of food service staff in nursing homes and long-term care facilities for the elderly in Sicily, Italy. Association with some demographic and work-related variables was also investigated. This survey provides information and outlines many complex questions concerning the basics of food hygiene. Education level, length of service in the employment and attending courses on food hygiene influenced the knowledge, attitudes and practices of food service staff. This study has evidenced the need for continuous training among food service staff regarding food safety in LTCF and nursing homes