"Mothers as Candy Wrappers": Critical Infrastructure Supporting the Transition into Motherhood

Copyright © ACM. The transition into motherhood is a complicated and often unsupported major life disruption. To alleviate mental health issues and to support identity re-negotiation, mothers are increasingly turning to online mothers\u27 groups, particularly private and secret Facebook groups; these can provide a complex system of social, emotional, and practical support for new mothers. In this paper we present findings from an exploratory interview study of how new mothers create, find, use, and participate in ICTs, specifically online mothers\u27 groups, to combat the lack of formal support systems by developing substitute networks. Utilizing a framework of critical infrastructures, we found that these online substitute networks were created by women, for women, in an effort to fill much needed social, political, and medical gaps that fail to see \u27woman and mother\u27 as a whole being, rather than simply as a \u27discarded candy wrapper\u27. Our study contributes to the growing literature on ICT use by mothers for supporting and negotiating new identities, by illustrating how these infrastructures can be re-designed and appropriated in use, for critical utilization

Communication interventions in adult and pediatric oncology: A scoping review and analysis of behavioral targets

BackgroundImproving communication requires that clinicians and patients change their behaviors. Interventions might be more successful if they incorporate principles from behavioral change theories. We aimed to determine which behavioral domains are targeted by communication interventions in oncology.MethodsSystematic search of literature indexed in Ovid Medline, Embase, Scopus, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov (2000-October 2018) for intervention studies targeting communication behaviors of clinicians and/or patients in oncology. Two authors extracted the following information: population, number of participants, country, number of sites, intervention target, type and context, study design. All included studies were coded based on which behavioral domains were targeted, as defined by Theoretical Domains Framework.FindingsEighty-eight studies met inclusion criteria. Interventions varied widely in which behavioral domains were engaged. Knowledge and skills were engaged most frequently (85%, 75/88 and 73%, 64/88, respectively). Fewer than 5% of studies engaged social influences (3%, 3/88) or environmental context/resources (5%, 4/88). No studies engaged reinforcement. Overall, 7/12 behavioral domains were engaged by fewer than 30% of included studies. We identified methodological concerns in many studies. These 88 studies reported 188 different outcome measures, of which 156 measures were reported by individual studies.ConclusionsMost communication interventions target few behavioral domains. Increased engagement of behavioral domains in future studies could support communication needs in feasible, specific, and sustainable ways. This study is limited by only including interventions that directly facilitated communication interactions, which excluded stand-alone educational interventions and decision-aids. Also, we applied stringent coding criteria to allow for reproducible, consistent coding, potentially leading to underrepresentation of behavioral domains

Novel Mechanisms Regulating Cytokine-induced Gene Expression in Astrocytes and Glioblastoma Cells

Chronic inflammation in the brain results in the development of several CNS diseases, including Alzheimer’s and Parkinson’s diseases, multiple sclerosis, and tumors. IL-1, a pro-inflammatory cytokine released by activated microglia and astrocytes, instigates the expression of factors promoting the progression of these CNS disorders, including cytokines, chemokines, and components of matrix remodeling systems, such as the plasminogen activator system. IL-1 also increases the mRNA expression and activity of SphK, the enzyme that phosphorylates Sph to form S1P, a bio-active sphingolipid. This thesis demonstrates that IL-1 and S1P enhance the mRNA and protein expression of PAI-1 and uPAR, two key components of the plasminogen activator system, in glioblastoma cells. The S1P-induced mRNA expression of PAI-1 and uPAR is mediated by the S1P2 receptor, and requires Rho-kinase and MEK1. However, IL-1 regulation of PAI-1 and uPAR mRNA expression is independent of SphK, and thus S1P. IL-1- and S1P-induced mRNA expression of PAI-1 and uPAR results in the increased in vitro invasion of glioblastoma cells. Since significant amounts of IL-1 are secreted from gliomas, and it increases the production of S1P via inciting the activity and mRNA expression of SphK, we propose a mechanism by which S1P and IL-1 influence the invasion of glioblastoma cells by increasing the mRNA and protein expression of uPAR and PAI-1. IL-1 and S1P also influence the mRNA expression of chemokines implicated in the development and progression of multiple sclerosis, namely IP-10 and RANTES, in primary human astrocytes. IP-10 and RANTES attract T cells, which are the major pathological cause of multiple sclerosis. This thesis demonstrates a novel mechanism by which S1P significantly inhibits the IL-1-induced mRNA expression of these chemokines. The mechanism by which S1P reduces IL-1-induced IP-10 and RANTES mRNA expression involves the prolonged hyperphosphorylation of TAK1, as well as the inhibition of IL-1-stimulated IFN beta production and the phosphorylation of STAT1 and STAT2. In summary, this dissertation describes the mechanisms by which S1P and IL-1 control the mRNA expression of two chemokines associated with multiple sclerosis, and the components of the plasminogen activator system, which are critical for the invasion of glioblastoma cells; thus, indicating future therapeutic targets for destructive CNS disorders

The Incredible Shrinking Letter: How Font Size Affects the Legibility of Text Viewed in Brief Glances

As in-vehicle interfaces have become miniature computers with userfacing LCD screens, the complexities of designing for them have increased tremendously. Given their safety-critical nature, designers must carefully consider every aspect of the vehicle’s digital interface. Recent research has suggested that even the typeface used to display the interface’s text can have significant impacts on driver behaviors such as total off-road glance time and secondary task completion time. Here we outline a psychophysical method for rapidly assessing the glance-based legibility of two different typefaces (a “humanist” and a “square grotesque”) presented in two different sizes (3mm and 4mm). Consistent with previous research, we find that humanist type is more legible than square grotesque. We also find that text is empirically less legible at 3mm compared to 4mm, and that this effect is especially pronounced for the square grotesque typeface. Legibility thresholds were also found to increase linearly with age, more than doubling across the age range studied. We hypothesize that the square grotesque’s intrinsic design characteristics cause it to scale poorly at small sizes and lose important details, especially in suboptimal display conditions

Connecting Chemical Composition and Methane Production in a West Michigan Peatland

The future net radiative forcing of peatlands will depend in large part on changes in methane emissions. However, current climate models lack a mechanistic representation of methane production. We conducted an anaerobic incubation experiment using peat from various depths in five cores collected from a West Michigan peatland in order to connect methane production to observable differences in the chemical composition of peat and peat pore water. We hypothesized that less decomposed peat may have a larger supply of fermentable sugars that can thus produce more methane than more decomposed peat. C:N, hydrolyzable amino acids, and neutral sugars were analyzed to evaluate the “quality” of the peat. Our results indicated that surface peat produces more methane and carbon dioxide than samples taken from greater depths. Surface peat had higher yields of arabinose and xylose, indicating higher availability of relatively labile hemicelluloses compared to deeper peat. This coincided with a higher amino acid yield in comparison to total nitrogen and a higher C:N, indicating less extensive decomposition in these samples. This is consistent with our hypothesis that methane production potential is correlated with peat quality. These results suggest that analysis of the chemical composition of peat can be used to assess methane production potential and predict the future radiative forming of peatlands

The value of tablets as reading aids for individuals with central visual field loss:an evaluation of eccentric reading with static and scrolling text

Purpose: Technological devices such as smartphones and tablets are widely available and increasingly used as visual aids. This study evaluated the use of a novel app for tablets (MD_evReader) developed as a reading aid for individuals with a central field loss resulting from macular degeneration. The MD_evReader app scrolls text as single lines (similar to a news ticker) and is intended to enhance reading performance using the eccentric viewing technique by both reducing the demands on the eye movement system and minimising the deleterious effects of perceptual crowding. Reading performance with scrolling text was compared with reading static sentences, also presented on a tablet computer. Methods: Twenty-six people with low vision (diagnosis of macular degeneration) read static or dynamic text (scrolled from right to left), presented as a single line at high contrast on a tablet device. Reading error rates and comprehension were recorded for both text formats, and the participant’s subjective experience of reading with the app was assessed using a simple questionnaire. Results: The average reading speed for static and dynamic text was not significantly different and equal to or greater than 85 words per minute. The comprehension scores for both text formats were also similar, equal to approximately 95% correct. However, reading error rates were significantly (p=0.02) less for dynamic text than for static text. The participants’ questionnaire ratings of their reading experience with the MD_evReader were highly positive and indicated a preference for reading with this app compared with their usual method. Conclusions: Our data show that reading performance with scrolling text is at least equal to that achieved with static text and in some respects (reading error rate) is better than static text. Bespoke apps informed by an understanding of the underlying sensorimotor processes involved in a cognitive task such as reading have excellent potential as aids for people with visual impairments

Temperature Sensitivity of Nitrogen Mineralization in Peat From a Southwestern Michigan Bog

In this study, we measured inorganic nitrogen (nitrate and ammonium) released from peat cores from Miner Lake bog at two temperatures to analyze the impact of climate warming on the peatland nitrogen cycle. We hypothesized a higher nitrogen release in samples incubated at warmer temperatures. Furthermore, previous research indicates shallow peat decomposes faster than deeper peat. Therefore, we hypothesized faster nitrogen mineralization in shallow samples. We collected peat cores from two locations from Miner Lake Bog in Allegan County, Michigan: a plot in the center of the bog and a sedge meadow site near the edge. Two samples for each depth (0-0.5 meter, 1.5-2 meters) were taken at both sites and homogenized. Microlysimeters, consisting of two-chambered filter towers, were acid washed and 20 g of acid washed sand was added to each upper chamber. 50 g of peat was added onto the sand and was left to equilibrate for four days. Microlysimeters were leached with 80 mL of 0.01M CaCl2 solution and the concentration of nitrate and ammonium in the leachate were quantified using ion chromatography. Microlysimeters were incubated for two weeks before leaching procedures were repeated. A separate field-based cation-anion exchange analysis was performed through the installation of plant root simulators. In both the lab and field experiments, we consistently found that cumulative mineralization was higher at the warmer temperature, indicating that warming will increase the rate of nitrogen cycling in peatlands. We also found that at a lesser extent mineralization was higher in surface peat than in more degraded deep peat layers

The Shifting Demographic Landscape of Pandemic Influenza

Shweta Bansal is with Pennsylvania State University and NIH, Babak Pourbohloul is with British Columbia Centre for Disease Control and University of British Columbia, Nathaniel Hupert is with Weill Cornell Medical College and CDC, Bryan Grenfell is with Princeton University, Lauren Ancel Meyers is with UT Austin and Santa Fe Institute.Background -- As Pandemic (H1N1) 2009 influenza spreads around the globe, it strikes school-age children more often than adults. Although there is some evidence of pre-existing immunity among older adults, this alone may not explain the significant gap in age-specific infection rates. Methods and Findings -- Based on a retrospective analysis of pandemic strains of influenza from the last century, we show that school-age children typically experience the highest attack rates in primarily naive populations, with the burden shifting to adults during the subsequent season. Using a parsimonious network-based mathematical model which incorporates the changing distribution of contacts in the susceptible population, we demonstrate that new pandemic strains of influenza are expected to shift the epidemiological landscape in exactly this way. Conclusions -- Our analysis provides a simple demographic explanation for the age bias observed for H1N1/09 attack rates, and suggests that this bias may shift in coming months. These results have significant implications for the allocation of public health resources for H1N1/09 and future influenza pandemics.This work was supported by the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health (NIH); grants from the James F. McDonnell Foundation, National Science Foundation (DEB-0749097), and NIH Models of Infectious Disease Agent Study (MIDAS) (U01-GM087719-01) to L.A.M.; and support from the Canadian Institutes of Health Research (PTL97125 and PAP93425) and the Michael Smith Foundation for Health Research to B.P. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o

Firearm Availability and Storage Practices Among Military Personnel Who Have Thought About Suicide

More than 60% of US military suicides occur at home and involve a firearm. Nearly all military firearm suicides (95%) involve a personally owned firearm. Nonmilitary data indicate that the risk of suicide is 6 times higher in households with a firearm, although this risk may be reduced if the firearms are kept unloaded and/or locked. Because attempts using firearms have very high fatality rates, safe firearm storage practices could be an important component of comprehensive suicide prevention in the military. This study examined associations of firearm ownership and storage practices with suicidal thoughts and behaviors among military personnel