I-eAT, a consortium addressing gastronomic solutions for altered taste: A research and development manifesto

An International Altered Taste Consortium (I-eAT) is proposed that seeks to utilise gastronomic and biopsychosocial insights to understand and help people who experience taste alterations. Altered eating experiences and a changed experience of taste is a common and disabling trans-diagnostic, multi-causal entity which has for too long been poorly understood and supported in health research and practice. The phrase Altered Taste is employed (using “taste” in its most commonly understood sense to refer to the overall multi-sensory flavour experience) to emphasise the lived sensory experience of those living with an altered relationship with food. Interdisciplinary collaboration between the domains of medicine, health care, physiology, psychology and gastronomy is considered key to understanding, working with and improving altered taste. This manifesto emerged from ongoing research and practice, and was formulated at a workshop of interdisciplinary experts and patient representatives at the Second International Altered Taste Symposium (2022). Between them they collectively agreed on 1. A shared terminology to maximise stakeholder involvement and 2. An overall research aim to better understand, manage and treat Altered Taste. This aim is implemented in 4 key research objectives

Optimal management of breast cancer in the elderly patient: current perspectives

Olivia Le Saux,1 Bertrand Ripamonti,2 Amandine Bruyas,3,4 Olivier Bonin,4 Gilles Freyer,1,4 Marc Bonnefoy,4,5 Claire Falandry4,51Medical Oncology Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, 2Gynaecology-Obstetrics Department, University Hospital, Saint-Etienne, 3Croix Rousse University Hospital, Hospices Civils de Lyon, Pierre-Bénite, 4Lyon University, Lyon, 5Geriatric Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, FranceAbstract: Breast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.Keywords: elderly, breast cancer, geriatric assessment, surgery, chemotherapy, radiotherap

Optimal management of breast cancer in the elderly patient: current perspectives

International audienceBreast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting

Evisto (R) a way to produce ultra-thin gravity die castings

International audienceThe massive use of air gaps in tooling, per the Evistoe (R) concept, can confine the heat contributed by the cast alloy in a small volume. The resulting high die wall temperatures are turned to account to cast parts having ultra-thin walls, of the order of one millimetre thick. Effective thermal insulation limits thermal exchanges to slow the cooling of a cast alloy. The property that best characterizes this effectiveness is the reciprocal of thermal conductivity, thermal resistance. Air was chosen as the insulating material because of its many advantages: very favourable thermal conductivity, limited application cost, and zero purchase cost. Evistoe (R), an innovative tooling design, has been used to produce plates 1 mm thick measuring 130 by 200 mm and automobile seat backs 1.2 mm thick measuring 390 by 576 mm. The mechanical properties of the castings so produced complied with standard EN 1706 of May 2010 for aluminium alloy castings. A patent application was filed for the Evisto (R) concept in August 2010

La zone pellucide bovine : différences de composition macromoléculaire entre ovocytes, prétraités ou non à l'A 23187, et embryons

International audienc

Proceedings of the 5th Driver Distraction and Inattention conference, Paris, March 20-22-2017

DDI 2017, Driver Distraction and Inattention - Meeting the Challenges of New Technology and Automation, PARIS, FRANCE, 20-/03/2017 - 22/03/2017The 5th International Conference on Driver Distraction and Inattention, DDI2017, aimed to bring participants up-to-date on recent developments and trends in the field of inattention and distraction in driving, and to bring together researchers and practitioners. Participants presented and discussed current work covering basic and applied research, mitigation challenges, the latest policy developments, and priorities for research and countermeasures development