3D Morphological modeling of a polycrystaline microstructure with non-convex, anisotropic grains

International audienceTATB (1,3,5-triamino-2,4,6-trinitrobenzene) is an energetic molecular crystal that combines high energetic performance and good thermal stability. By adding a small amount of a polymer acting as a binder between TATB grains, it is possible to obtain exceptionally safe explosives displaying good mechanical properties. A first step toward the understanding of the influence of the microstructure on the mechanical properties of TATB is the development of stochastic models to describe the microstructure of the material

SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells

Significance Lysosomes are degradative intracellular organelles essential to cell maintenance and homeostasis. Although their degradative function is well documented, the proteins responsible for the efflux, and reuse, of lysosomal degradation products remain largely unknown. In this study, we identify the transporter responsible for lysosomal efflux of glutamine, an amino acid central to several key metabolic pathways. This central role of glutamine is exploited by several types of cancer cells with increased consumption of glutamine. Interestingly, genetic inactivation of the transporter impairs their growth under conditions of limited glutamine availability when internalized extracellular proteins are used as an alternative source of amino acids, suggesting novel approaches for anticancer therapies.</jats:p

Ion and Molecule Transport in Lysosomes

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Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters

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Intracellular localization and biochemical characterization of CNL7, a putative lysosomal transporter associated with late-infantile ceroid lipofuscinosis.

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Molecular physiology and pathophysiology of two lysosomal transporters (sialin and cystinosin)

LE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF

Technical and economic assessment tool for offshore wind generation connection scheme: application to comparing 33kV and 66kV AC collector grids

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