4 research outputs found
CDH11 Expression is Associated with Survival in Patients with Osteosarcoma
Previous studies have shown that cadherin-11 (CDH11) may be involved in the
metastatic process of osteosarcoma. The correlation of the expression levels of
CDH11 in osteosarcoma samples with the risk of disease progression and metastasis
was examined. Real time qRT-PCR was used to quantify CDH11 expression in a set of
newly established osteosarcoma cell lines, 11 primaries and five metastases,
compared to the levels in 12 normal osteoblast cell lines established from
healthy bone, and also in a set of 10 snap-frozen osteosarcoma samples. In all
cases long term clinical follow-up data was available. The CDH11 expression level
decreased gradually from the osteoblast to the primary cell lines (p=0.2184) and
further to those established from the tumor metastases (p=0.0275). Importantly,
the level of CDH11 expression correlated significantly (p=0.01) with patient
survival (Kaplan-Meier survival analysis) in both sample sets (p=0.0128 for the
cell lines, p=0.0492 for the biopsies). In conclusion, the results indicate that
CDH11 may be useful as a prognostic marker of disease progression and survival in
osteosarcoma