Development of a soundscape simulator tool

This paper discusses the development of an interactive soundscape simulator, enabling users to manipulate a series of parameters to investigate if there is group correlation between factors such as source selection, positioning and level. The basis of the simulator stems from fieldwork and recordings carried out in London and Manchester. Through the use of an enhanced version of soundwalking, respondents are led on a walk around an urban space focusing on the soundscape, whilst answering questions in a semi-structured interview. The data collected is then used to inform the ecological validity of the simulator. The laboratory based tests use simulations based on spaces recorded in a series of urban locations, as well as an ‘idealised’ soundscape simulation, featuring data from all recorded locations. The sound sources used are based on user highlighted selections from all locations, based on preferences extracted from soundwalk field data. Preliminary results show the simulator is effective in obtaining numerical data based on subjective choices as well as, effective qualitative data which provides an insight into the reasoning behind the respondents choices. This work forms part of the Positive Soundscape Project

The effects of expectation on the perception of soundscapes

This paper explores how expectations of a place and its soundscape can affect our perception of that soundscape. Previous soundscape research has included expectation as one possible element of the context in which soundscape evaluation takes place. This work aimed to focus on expectation and unpack it to improve understanding of its different components and how it works. A combination of soundwalks, interviews, focus groups and an interactive soundscape simulation were used in the investigation. A linked series of locations in Manchester and London were studied. It was found that participants’ perceptions of a soundscape, both real and simulated, were affected by expectation in several different ways. Participants expected certain types of sound to be present in a particular space. Participants distinguished between whether a sound was expected and whether it sounded pleasant. It was also possible to distinguish between the expectation of particular sound sources and the expectation of the soundscape as a whole. The latter was found to be driven significantly by prior experience of similar spaces and also by perceived loudness. Participants also had expectations about the type of activity they could undertake in a particular soundscape, the behaviour of other people as expressed in the soundscape, and the degree of control they might have over their own exposure to the sound. These findings suggest that expectations of a soundscape are based on prior experience in a way which is consistent with Truax’s notion of soundscape competence. The results have been used to produce a new model for soundscape expectation which is expressed as a flowchart

The positive soundscape project : a synthesis of results from many disciplines

This paper takes an overall view of ongoing findings from the Positive Soundscape Project, a large inter-disciplinary soundscapes study which is nearing completion. Qualitative fieldwork (soundwalks and focus groups) and lab-based listening tests have revealed that two key dimensions of the emotional response are calmness and vibrancy. In the lab these factors explain nearly 80% of the variance in listener response. Physiological validation is being sought using fMRI measurements, and these have so far shown significant differences in the response of the brain to affective and neutral soundscapes. A conceptual framework which links the key soundscape components and which could be used for future design is outlined. Metrics are suggested for some perceptual scales and possibilities for soundscape synthesis for design and user engagement are discussed, as are the applications of the results to future research and environmental noise policy

Comparative population structure of <i>Plasmodium malariae</i> and <i>Plasmodium falciparum</i> under different transmission settings in Malawi

&lt;b&gt;Background:&lt;/b&gt; Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increasingly important. This study compares the population parameters of the two species in two districts of Malawi with different malaria transmission patterns - one seasonal, one perennial - to explore the effects of transmission on population structures. &lt;BR/&gt; &lt;b&gt;Methods:&lt;/b&gt; Six species-specific microsatellite markers were used to analyse 257 P. malariae samples and 257 P. falciparum samples matched for age, gender and village of residence. Allele sizes were scored to within 2 bp for each locus and haplotypes were constructed from dominant alleles in multiple infections. Analysis of multiplicity of infection (MOI), population differentiation, clustering of haplotypes and linkage disequilibrium was performed for both species. Regression analyses were used to determine association of MOI measurements with clinical malaria parameters. &lt;BR/&gt; &lt;b&gt;Results:&lt;/b&gt; Multiple-genotype infections within each species were common in both districts, accounting for 86.0% of P. falciparum and 73.2% of P. malariae infections and did not differ significantly with transmission setting. Mean MOI of P. falciparum was increased under perennial transmission compared with seasonal (3.14 vs 2.59, p = 0.008) and was greater in children compared with adults. In contrast, P. malariae mean MOI was similar between transmission settings (2.12 vs 2.11) and there was no difference between children and adults. Population differentiation showed no significant differences between villages or districts for either species. There was no evidence of geographical clustering of haplotypes. Linkage disequilibrium amongst loci was found only for P. falciparum samples from the seasonal transmission setting. &lt;BR/&gt; &lt;b&gt;Conclusions:&lt;/b&gt; The extent of similarity between P. falciparum and P. malariae population structure described by the high level of multiple infection, the lack of significant population differentiation or haplotype clustering and lack of linkage disequilibrium is surprising given the differences in the biological features of these species that suggest a reduced potential for out-crossing and transmission in P. malariae. The absence of a rise in P. malariae MOI with increased transmission or a reduction in MOI with age could be explained by differences in the duration of infection or degree of immunity compared to P. falciparum

Soundscape reproduction and synthesis

The aims of this work were to investigate (i) whether soundscape perceptual dimensions are correctly reproduced by ambisonic loudspeaker playback, (ii) whether soundscape dimensional analysis is robust to changes of location and from the field to laboratory playback, and (iii) whether a simple soundscape synthesis can be used to interactively design a soundscape. The first two aims were addressed by an experiment which attempted to repeat the dimensional analysis made by Kang (Kang, J. (2007), Urban Sound Environment. London: Taylor and Francis). Kang used semantic differential scales to conduct an in-situ survey of two urban soundscapes in Sheffield, UK. He used factor analysis to derive four perceptual dimensions from the responses. The present work repeated this approach, but the fifteen participants were judging ambisonic recordings of four soundscapes in Manchester, UK. The present work found very similar dimensions to Kang but with more variance explained: relaxation/calmness (41%), dynamics/vibrancy (10%), communication (7%) and spatiality (7%). The dimensions from the two studies load onto the semantic scales in a similar way. These results indicate that an ambisonic reproduction of a soundscape gives similar results to field experiments, though with more variance explained. They also show that dimensional analysis of soundscape response is robust enough to produce similar results for different locations in different cities. To investigate the third aim, the ambisonic reproduction was extended to a system which allowed independent interactive control of sixteen foreground sounds set in an ambisonic background soundscape. Eight participants were able to use this system to successfully design a soundscape that expressed their intentions. It was found that the designed soundscapes seemed to be based more on participant expectation of typical urban soundscapes than on their preference for individual sounds. These results suggest that a more sophisticated soundscape synthesiser might be suitable for real design problems

An activity-centric conceptual framework for assessing and creating positive urban soundscapes

The Positive Soundscapes Project is an interdisciplinary investigation of soundscape perception [1]. The project seeks to develop a rounded view of human perception of soundscapes by drawing together methods from the disciplines of engineering sound quality [2], acoustics, psychoacoustics, physiology [3], as well as sound art, acoustic ecology and social science [4]. In the acoustics community, sound in the environment, especially that made by other people has overwhelmingly been considered in negative terms as both intrusive and undesirable. The strong focus of traditional engineering acoustics on reducing noise levels ignores the many possibilities for characterizing positive aspects of the soundscape, whereas art and social science disciplines interpret soundscape perception as a multimodal and multi-dimensional concept. The project team come from a wide range of disciplines and are applying their experiences to investigate soundscapes from different aspects to produce a more nuanced and complete picture of listener response than has so far been achieved. In order for the team behind the project to achieve this, an underpinning framework is required, by which to approach and move the project forward, while aligning thinking from the different disciplines. This paper describes a high-level first iteration of the conceptual framework, which is structured in three parts. The use and potential application of the framework within the Positive Soundscapes Project is then discussed

Physical and mental health comorbidity is common in people with multiple sclerosis: nationally representative cross-sectional population database analysis

&lt;b&gt;Background&lt;/b&gt; Comorbidity in Multiple Sclerosis (MS) is associated with worse health and higher mortality. This study aims to describe clinician recorded comorbidities in people with MS. &lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods&lt;/b&gt; 39 comorbidities in 3826 people with MS aged ≥25 years were compared against 1,268,859 controls. Results were analysed by age, gender, and socioeconomic status, with unadjusted and adjusted Odds Ratios (ORs) calculated using logistic regression. &lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt; People with MS were more likely to have one (OR 2.44; 95% CI 2.26-2.64), two (OR 1.49; 95% CI 1.38-1.62), three (OR 1.86; 95% CI 1.69-2.04), four or more (OR 1.61; 95% CI 1.47-1.77) non-MS chronic conditions than controls, and greater mental health comorbidity (OR 2.94; 95% CI 2.75-3.14), which increased as the number of physical comorbidities rose. Cardiovascular conditions, including atrial fibrillation (OR 0.49; 95% CI 0.36-0.67), chronic kidney disease (OR 0.51; 95% CI 0.40-0.65), heart failure (OR 0.62; 95% CI 0.45-0.85), coronary heart disease (OR 0.64; 95% CI 0.52-0.71), and hypertension (OR 0.65; 95% CI 0.59-0.72) were significantly less common in people with MS. &lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion&lt;/b&gt; People with MS have excess multiple chronic conditions, with associated increased mental health comorbidity. The low recorded cardiovascular comorbidity warrants further investigation

How are falls and fear of falling associated with objectively measured physical activity in a cohort of community-dwelling older men?

BACKGROUND: Falls affect approximately one third of community-dwelling older adults each year and have serious health and social consequences. Fear of falling (FOF) (lack of confidence in maintaining balance during normal activities) affects many older adults, irrespective of whether they have actually experienced falls. Both falls and fear of falls may result in restrictions of physical activity, which in turn have health consequences. To date the relation between (i) falls and (ii) fear of falling with physical activity have not been investigated using objectively measured activity data which permits examination of different intensities of activity and sedentary behaviour. METHODS: Cross-sectional study of 1680 men aged 71-92 years recruited from primary care practices who were part of an on-going population-based cohort. Men reported falls history in previous 12 months, FOF, health status and demographic characteristics. Men wore a GT3x accelerometer over the hip for 7 days. RESULTS: Among the 12% of men who had recurrent falls, daily activity levels were lower than among non-fallers; 942 (95% CI 503, 1381) fewer steps/day, 12(95% CI 2, 22) minutes less in light activity, 10(95% CI 5, 15) minutes less in moderate to vigorous PA [MVPA] and 22(95% CI 9, 35) minutes more in sedentary behaviour. 16% (n = 254) of men reported FOF, of whom 52% (n = 133) had fallen in the past year. Physical activity deficits were even greater in the men who reported that they were fearful of falling than in men who had fallen. Men who were fearful of falling took 1766(95% CI 1391, 2142) fewer steps/day than men who were not fearful, and spent 27(95% CI 18, 36) minutes less in light PA, 18(95% CI 13, 22) minutes less in MVPA, and 45(95% CI 34, 56) minutes more in sedentary behaviour. The significant differences in activity levels between (i) fallers and non-fallers and (ii) men who were fearful of falling or not fearful, were mediated by similar variables; lower exercise self-efficacy, fewer excursions from home and more mobility difficulties. CONCLUSIONS: Falls and in particular fear of falling are important barriers to older people gaining health benefits of walking and MVPA. Future studies should assess the longitudinal associations between falls and physical activity

Interstellar Turbulence II: Implications and Effects

Interstellar turbulence has implications for the dispersal and mixing of the elements, cloud chemistry, cosmic ray scattering, and radio wave propagation through the ionized medium. This review discusses the observations and theory of these effects. Metallicity fluctuations are summarized, and the theory of turbulent transport of passive tracers is reviewed. Modeling methods, turbulent concentration of dust grains, and the turbulent washout of radial abundance gradients are discussed. Interstellar chemistry is affected by turbulent transport of various species between environments with different physical properties and by turbulent heating in shocks, vortical dissipation regions, and local regions of enhanced ambipolar diffusion. Cosmic rays are scattered and accelerated in turbulent magnetic waves and shocks, and they generate turbulence on the scale of their gyroradii. Radio wave scintillation is an important diagnostic for small scale turbulence in the ionized medium, giving information about the power spectrum and amplitude of fluctuations. The theory of diffraction and refraction is reviewed, as are the main observations and scintillation regions.Comment: 46 pages, 2 figures, submitted to Annual Reviews of Astronomy and Astrophysic

Investigation into mercury bound to biothiols: structural identification using ESI–ion-trap MS and introduction of a method for their HPLC separation with simultaneous detection by ICP-MS and ESI-MS

Mercury in plants or animal tissue is supposed to occur in the form of complexes formed with biologically relevant thiols (biothiols), rather than as free cation. We describe a technique for the separation and molecular identification of mercury and methylmercury complexes derived from their reactions with cysteine (Cys) and glutathione (GS): Hg(Cys)2, Hg(GS)2, MeHgCys, MeHgGS. Complexes were characterised by electrospray mass spectrometry (MS) equipped with an ion trap and the fragmentation pattern of MeHgCys was explained by using MP2 and B3LYP calculations, showing the importance of mercury–amine interactions in the gas phase. Chromatographic baseline separation was performed within 10 min with formic acid as the mobile phase on a reversed-phase column. Detection was done by online simultaneous coupling of ES-MS and inductively coupled plasma MS. When the mercury complexes were spiked in real samples (plant extracts), no perturbation of the separation and detection conditions was observed, suggesting that this method is capable of detecting mercury biothiol complexes in plants