327 research outputs found
Targeted free energy perturbation
A generalization of the free energy perturbation identity is derived, and a
computational strategy based on this result is presented. A simple example
illustrates the efficiency gains that can be achieved with this method.Comment: 8 pages + 1 color figur
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population
Background: We investigated the associations among cardiovascular risk factors, carotid atherosclerosis and cognitive function in a Canadian First Nations population. Methods: Individuals aged ≥18 years, without stroke, nonpreg- nant and with First Nations status were assessed by the Trail Making Test Parts A and B. Results were combined into a Trail Making Test executive function score (TMT-exec). Doppler ultrasonography assessed carotid stenosis and plaque volume. Anthropometric, vascular and metabolic risk factors were assessed by interview, clinical examinations and blood tests. Results: For 190 individuals with TMT-exec scores, the median age of the population was 39 years. Compared to the reference group, individuals with elevated levels of left carotid stenosis (LCS) and total carotid stenosis (TCS) were less likely to demonstrate lowered cognitive performance [LCS, odds ratio (OR): 0.47, 95% confidence interval (CI): 0.24-0.96; TCS, OR: 0.40, 95% CI: 0.20-0.80]. No effect was shown for plaque volume. In structural equation modeling, we found that for every 1-unit change in the anthropometric factor in kg/m2, there was a 0.86-fold decrease in the percent of TCS (p \u3c 0.05). Conclusions: Individuals with elevated levels of LCS and TCS were less likely to demonstrate lowered performance. There was some suggestion that TCS mediates the effect of anthropometric risk factors on cognitive function. Copyright © 2009 S. Karger AG, Basel
Conformal Field Theories, Representations and Lattice Constructions
An account is given of the structure and representations of chiral bosonic
meromorphic conformal field theories (CFT's), and, in particular, the
conditions under which such a CFT may be extended by a representation to form a
new theory. This general approach is illustrated by considering the untwisted
and -twisted theories, and respectively,
which may be constructed from a suitable even Euclidean lattice .
Similarly, one may construct lattices and by
analogous constructions from a doubly-even binary code . In the case when
is self-dual, the corresponding lattices are also. Similarly,
and are self-dual if and only if is. We show that
has a natural ``triality'' structure, which induces an
isomorphism and also a triality
structure on . For the Golay code,
is the Leech lattice, and the triality on is the symmetry which extends the natural action of (an
extension of) Conway's group on this theory to the Monster, so setting triality
and Frenkel, Lepowsky and Meurman's construction of the natural Monster module
in a more general context. The results also serve to shed some light on the
classification of self-dual CFT's. We find that of the 48 theories
and with central charge 24 that there are 39 distinct ones,
and further that all 9 coincidences are accounted for by the isomorphism
detailed above, induced by the existence of a doubly-even self-dual binary
code.Comment: 65 page
Primordialists and Constructionists: a typology of theories of religion
This article adopts categories from nationalism theory to classify theories of religion. Primordialist explanations are grounded in evolutionary psychology and emphasize the innate human demand for religion. Primordialists predict that religion does not decline in the modern era but will endure in perpetuity. Constructionist theories argue that religious demand is a human construct. Modernity initially energizes religion, but subsequently undermines it. Unpacking these ideal types is necessary in order to describe actual theorists of religion. Three distinctions within primordialism and constructionism are relevant. Namely those distinguishing: a) materialist from symbolist forms of constructionism; b) theories of origins from those pertaining to the reproduction of religion; and c) within reproduction, between theories of religious persistence and secularization. This typology helps to make sense of theories of religion by classifying them on the basis of their causal mechanisms, chronology and effects. In so doing, it opens up new sightlines for theory and research
Theory of Coexistence of Superconductivity and Ferroelectricity : A Dynamical Symmetry Model
We propose and investigate a model for the coexistence of Superconductivity
(SC) and Ferroelectricity (FE) based on the dynamical symmetries for
the pseudo-spin SC sector, for the displaced oscillator FE sector, and
for the composite system. We assume a minimal
symmetry-allowed coupling, and simplify the hamiltonian using a double mean
field approximation (DMFA). A variational coherent state (VCS) trial
wave-function is used for the ground state: the energy, and the relevant order
parameters for SC and FE are obtained. For positive sign of the SC-FE coupling
coefficient, a non-zero value of either order parameter can suppress the other
(FE polarization suppresses SC and vice versa). This gives some support to
"Matthias' Conjecture" [1964], that SC and FE tend to be mutually exclusive.
For such a Ferroelectric Superconductor we predict: a) the SC gap
(and ) will increase with increasing applied pressure when pressure
quenches FE as in many ferroelectrics, and b) the FE polarization will increase
with increaesing magnetic field up to . The last result is equivalent to
the prediction of a new type of Magneto-Electric Effect in a coexistent SC-FE
material. Some discussion will be given of the relation of these results to the
cuprate superconductors.Comment: 46 page
A Markov chain model for changes in users’ assessment of search results
Previous research shows that users tend to change their assessment of search results over time. This is a first study that investigates the factors and reasons for these changes, and describes a stochastic model of user behaviour that may explain these changes. In particular, we hypothesise that most of the changes are local, i.e. between results with similar or close relevance to the query, and thus belong to the same ”coarse” relevance category. According to the theory of coarse beliefs and categorical thinking, humans tend to divide the range of values under consideration into coarse categories, and are thus able to distinguish only between cross-category values but not within them. To test this hypothesis we conducted five experiments with about 120 subjects divided into 3 groups. Each student in every group was asked to rank and assign relevance scores to the same set of search results over two or three rounds, with a period of three to nine weeks between each round. The subjects of the last three-round experiment were then exposed to the differences in their judgements and were asked to explain them. We make use of a Markov chain model to measure change in users’ judgments between the different rounds. The Markov chain demonstrates that the changes converge, and that a majority of the changes are local to a neighbouring relevance category. We found that most of the subjects were satisfied with their changes, and did not perceive them as mistakes but rather as a legitimate phenomenon, since they believe that time has influenced their relevance assessment. Both our quantitative analysis and user comments support the hypothesis of the existence of coarse relevance categories resulting from categorical thinking in the context of user evaluation of search results
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, we compared allele frequencies for 551 642 SNPs in 978 cases and 883 controls and assessed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion load and normalized brain volume from magnetic resonance imaging exams. A multi-analytical strategy identified 242 susceptibility SNPs exceeding established thresholds of significance, including 65 within the MHC locus in chromosome 6p21.3. Independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk. Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotyp
Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium
Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation of genotyping arrays with rare variants (e.g., minor allele frequency [MAF] <0.01) is the difficulty that automated clustering algorithms have to accurately detect and assign genotype calls. Combining intensity data from large numbers of samples may increase the ability to accurately call the genotypes of rare variants. Approximately 62,000 ethnically diverse samples from eleve
Population connectivity of the highly migratory shortfin mako (Isurus oxyrinchus Rafinesque 1810) and implications for management in the Southern Hemisphere
Published: 20 November 2018In this paper we combine analyses of satellite telemetry and molecular data to investigate spatial connectivity and genetic structure among populations of shortfin mako (Isurus oxyrinchus) in and around Australian waters, where this species is taken in recreational and commercial fisheries. Mitochondrial DNA data suggest matrilineal substructure across hemispheres, while nuclear DNA data indicate shortfin mako may constitute a globally panmictic population. There was generally high genetic connectivity within Australian waters. Assessing genetic connectivity across the Indian Ocean basin, as well as the extent that shortfin mako exhibit sex biases in dispersal patterns would benefit from future improved sampling of adult size classes, particularly of individuals from the eastern Indian Ocean. Telemetry data indicated that Australasian mako are indeed highly migratory and frequently make long-distance movements. However, individuals also exhibit fidelity to relatively small geographic areas for extended periods. Together these patterns suggest that shortfin mako populations may be genetically homogenous across large geographical areas as a consequence of few reproductively active migrants, although spatial partitioning exists. Given that connectivity appears to occur at different scales, management at both the national and regional levels seems most appropriate.Shannon Corrigan, Andrew D. Lowther, Luciano B. Beheregaray, Barry D. Bruce, Geremy Cliff, Clinton A. Duffy, Alan Foulis, Malcolm P. Francis, Simon D. Goldsworthy, John R. Hyde, Rima W. Jabado, Dovi Kacev, Lindsay Marshall, Gonzalo R. Mucientes, Gavin J. P. Naylor, Julian G. Pepperell, Nuno Queiroz, William T. White, Sabine P. Wintner and Paul J. Roger
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