180 research outputs found

    Cooling the optical-spin driven limit cycle oscillations of a levitated gyroscope

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    Birefringent microspheres, trapped in vacuum and set into rotation by circularly polarised light, demonstrate remarkably stable translational motion. This is in marked contrast to isotropic particles in similar conditions. Here we demonstrate that this stability is obtained because the fast rotation of these birefringent spheres reduces the effect of azimuthal spin forces created by the inhomogeneous optical spin of circularly polarised light. At reduced pressures, the unique profile of these rotationally averaged, effective azimuthal forces results in the formation of nano-scale limit cycles. We demonstrate feedback cooling of these non-equilibrium oscillators, resulting in effective temperatures on the order of a milliKelvin. The principles we elaborate here can inform the design of high-stability rotors carrying enhanced centripetal loads or result in more efficient cooling schemes for autonomous limit cycle oscillations. Ultimately, this latter development could provide experimental access to non-equilibrium quantum effects within the mesoscopic regime.Yoshihiko Arita, Stephen H. Simpson, Graham D. Bruce, Ewan M. Wright, Pavel Zemánek, Kishan Dholaki

    The GMAT Analytical Writing Assessment: Opportunitw or Threat for Management Communication?

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    Instituted as a regular part of the GMAT in October 1994, the Analytical Writing Assessment (AWA) has the potential to serve as a diagnostic tool in MBA programs. This article describes the new test and reviews the uses of the AWA scores and essays that have significant ramifications for management communication. It concludes by suggesting why it is vital for communication instructors to become involved in decisions about how to use the A WA results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68049/2/10.1177_108056999605900206.pd

    On recurrence and ergodicity for geodesic flows on noncompact periodic polygonal surfaces

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    We study the recurrence and ergodicity for the billiard on noncompact polygonal surfaces with a free, cocompact action of Z\Z or Z2\Z^2. In the Z\Z-periodic case, we establish criteria for recurrence. In the more difficult Z2\Z^2-periodic case, we establish some general results. For a particular family of Z2\Z^2-periodic polygonal surfaces, known in the physics literature as the wind-tree model, assuming certain restrictions of geometric nature, we obtain the ergodic decomposition of directional billiard dynamics for a dense, countable set of directions. This is a consequence of our results on the ergodicity of \ZZ-valued cocycles over irrational rotations.Comment: 48 pages, 12 figure

    Systematics of K-pi=8(-) isomers in N=74 nuclei

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    An isomer with a half-life of 6+/-1 mu s has been observed in the N=74 nucleus Gd-138, populated following the reaction Cd-106(Cl-35,p2n)Gd-138. Th, isomer decays via a 583 keV EI transition with a hindrance per degree of K forbiddenness, f(v)=24. This value is similar to the values measured for the N=74 isotones Nd-134 and Sm-136 but markedly different from that measured for Ba-130. This suggests that there is some change in structure across the N=74 isotones and possible explanations of this feature are discussed

    Rotation of an eight-quasiparticle isomer

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    A T-1/2 = 220 ns, eight-quasiparticle isomer, with four unpaired neutrons and four unpaired protons, has been established at an excitation energy of 6576 keV in the prolate deformed nucleus, W-178. The associated rotational band has also been identified, revealing the collective properties in the presence of blocked pairing correlations, with expected quenching of the nuclear superfluidity. The band retains a small degree of rotational alignment, and has a less-than-rigid dynamic moment of inertia

    Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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    We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 × 10−8), while five of the 21 lead SNPs reach suggestive significance (P < 1 × 10−5) for at least one other macronutrient. While the phenotypes are genetically correlated, each phenotype carries a partially unique genetic architecture. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease (rg ≈ 0.15–0.5). In contrast, relative carbohydrate and sugar intake have negative genetic correlations with waist circumference, waist-hip ratio, and neighborhood deprivation (|rg| ≈ 0.1–0.3) and positive genetic correlations with physical activity (rg ≈ 0.1 and 0.2). Relative fat intake has no consistent pattern of genetic correlations with poor health but has a negative genetic correlation with educational attainment (rg ≈−0.1). Although our analyses do not allow us to draw causal conclusions, we find no evidence of negative health consequences associated with relative carbohydrate, sugar, or fat intake. However, our results are consistent with the hypothesis that relative protein intake plays a role in the etiology of metabolic dysfunction

    Definition, aims, and implementation of GA2LEN/HAEi Angioedema Centers of Reference and Excellence

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    Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk

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    Background: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD. Methods: The Advancing Understanding of RecOvery afteR traumA (AURORA) study is a prospective cohort of adults presenting at emergency departments (N = 2,943). Participants self-reported PTSD symptoms and the frequency and quantity of tobacco, alcohol, and cannabis use at six total timepoints. We assessed the associations of PTSD and future substance use, lagged by one timepoint, using the Poisson generalized estimating equations. We also stratified by incident and prevalent substance use and generated causal forests to identify the most important effect modifiers of this relationship out of 128 potential variables. Results: At baseline, 37.3% (N = 1,099) of participants reported likely PTSD. PTSD was associated with tobacco frequency (incidence rate ratio (IRR): 1.003, 95% CI: 1.00, 1.01, p = 0.02) and quantity (IRR: 1.01, 95% CI: 1.001, 1.01, p = 0.01), and alcohol frequency (IRR: 1.002, 95% CI: 1.00, 1.004, p = 0.03) and quantity (IRR: 1.003, 95% CI: 1.001, 1.01, p = 0.001), but not with cannabis use. There were slight differences in incident compared to prevalent tobacco frequency and quantity of use; prevalent tobacco frequency and quantity were associated with PTSD symptoms, while incident tobacco frequency and quantity were not. Using causal forests, lifetime worst use of cigarettes, overall self-rated physical health, and prior childhood trauma were major moderators of the relationship between PTSD symptoms and the three substances investigated. Conclusion: PTSD symptoms were highly associated with tobacco and alcohol use, while the association with prospective cannabis use is not clear. Findings suggest that understanding the different risk stratification that occurs can aid in tailoring interventions to populations at greatest risk to best mitigate the comorbidity between PTSD symptoms and future substance use outcomes. We demonstrate that this is particularly salient for tobacco use and, to some extent, alcohol use, while cannabis is less likely to be impacted by PTSD symptoms across the strata

    5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

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