Terrorist use of weapons of mass destruction: how serious is the threat?

Basingstoke, U

Plan Dalet in the Context of the Contradictions of Zionism

Plan Dalet played an important role in the Palestinian mass flight in April and May 1948. The question of the Zionists' intention with regard to this is still the subject of scholarly debate. The central thesis of this article is that Plan Dalet and the Zionists' intention should be evaluated in the context of the contradiction between Zionism's moral and national ideals. This context is introduced with some examples from the history of Zionism in general. The interpretation in this context provides a fuller and more consistent explanation of Plan Dalet than a context that disregards either of Zionism's ideals

Synaptic, transcriptional and chromatin genes disrupted in autism.

The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate (FDR) < 0.05, plus a set of 107 autosomal genes strongly enriched for those likely to affect risk (FDR < 0.30). These 107 genes, which show unusual evolutionary constraint against mutations, incur de novo loss-of-function mutations in over 5% of autistic subjects. Many of the genes implicated encode proteins for synaptic formation, transcriptional regulation and chromatin-remodelling pathways. These include voltage-gated ion channels regulating the propagation of action potentials, pacemaking and excitability-transcription coupling, as well as histone-modifying enzymes and chromatin remodellers-most prominently those that mediate post-translational lysine methylation/demethylation modifications of histones

Christian Fundamentalists and Public Opinion Toward the Middle East: Israel's New Best Friends?

Although Christian fundamentalist elites have become increasingly vocal in their support for Israel in the ongoing conflict in the Middle East, it is not clear that this rhetoric has produced differing attitudes about U.S. foreign policy in public opinion. This article examines whether such differences exist, and whether they are rooted in aspects of fundamentalist eschatology. Copyright (c) 2004 by the Southwestern Social Science Association.

Synaptic, transcriptional and chromatin genes disrupted in autism

The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate (FDR) < 0.05, plus a set of 107 autosomal genes strongly enriched for those likely to affect risk (FDR < 0.30). These 107 genes, which show unusual evolutionary constraint against mutations, incur de novo loss-of-function mutations in over 5% of autistic subjects. Many of the genes implicated encode proteins for synaptic formation, transcriptional regulation and chromatin-remodelling pathways. These include voltage-gated ion channels regulating the propagation of action potentials, pacemaking and excitability-transcription coupling, as well as histone-modifying enzymes and chromatin remodellers-most prominently those that mediate post-translational lysine methylation/demethylation modifications of histones