118,707 research outputs found

    Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily

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    AbstractMicronemes are specialised organelles, found in all apicomplexan parasites, which secrete molecules that are essential for parasite attachment to and invasion of host cells. Regions of several microneme proteins have sequence similarity to the Apple domains (A-domains) of blood coagulation factor XI (FXI) and plasma pre-kallikrein (PK). We have used mass spectrometry on a recombinant-expressed, putative A-domain from the microneme protein EtMIC5 from Eimeria tenella, to demonstrate that three intramolecular disulphide bridges are formed. These bridges are analogous to those that stabilise A-domains in FXI and PK. The data confirm that the apicomplexan domains are structural homologues of A-domains and are therefore novel members of the PAN module superfamily, which also includes the N-terminal domains of members of the plasminogen/hepatocyte growth factor family. The role of A-domains/PAN modules in apicomplexan parasites is not known, but their presence in the microneme suggests that they may be important for mediating protein–protein or protein–carbohydrate interactions during parasite attachment and host cell invasion

    Molecular weight effects on chain pull-out fracture of reinforced polymeric interfaces

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    Using Brownian dynamics, we simulate the fracture of polymer interfaces reinforced by diblock connector chains. We find that for short chains the interface fracture toughness depends linearly on the degree of polymerization NN of the connector chains, while for longer chains the dependence becomes N3/2N^{3/2}. Based on the geometry of initial chain configuration, we propose a scaling argument that accounts for both short and long chain limits and crossover between them.Comment: 5 pages, 3 figure

    Universal measurement of quantum correlations of radiation

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    A measurement technique is proposed which, in principle, allows one to observe the general space-time correlation properties of a quantized radiation field. Our method, called balanced homodyne correlation measurement, unifies the advantages of balanced homodyne detection with those of homodyne correlation measurements.Comment: 4 pages, 4 figures, small misprints were corrected, accepted to Phys. Rev. Let

    Time-Reversal-Violating Schiff Moment of 199Hg

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    We calculate the Schiff moment of the nucleus 199Hg, created by pi-N-N vertices that are odd under parity (P) and time-reversal (T). Our approach, formulated in diagrammatic perturbation theory with important core-polarization diagrams summed to all orders, gives a close approximation to the expectation value of the Schiff operator in the odd-A Hartree-Fock-Bogoliubov ground state generated by a Skyrme interaction and a weak P- and T-odd pion-exchange potential. To assess the uncertainty in the results, we carry out the calculation with several Skyrme interactions (the quality of which we test by checking predictions for the isoscalar-E1 strength distribution in 208Pb) and estimate most of the important diagrams we omit.Comment: 13 pages, 7 figure

    Variable mixer propulsion cycle

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    A design technique, method and apparatus are delineated for controlling the bypass gas stream pressure and varying the bypass ratio of a mixed flow gas turbine engine in order to achieve improved performance. The disclosed embodiments each include a mixing device for combining the core and bypass gas streams. The variable area mixing device permits the static pressures of the core and bypass streams to be balanced prior to mixing at widely varying bypass stream pressure levels. The mixed flow gas turbine engine therefore operates efficiently over a wide range of bypass ratios and the dynamic pressure of the bypass stream is maintained at a level which will keep the engine inlet airflow matched to an optimum design level throughout a wide range of engine thrust settings

    Similitude requirements and scaling relationships as applied to model testing

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    The similitude requirements for the most general test conditions are presented. These similitude requirements are considered in relation to the scaling relationships, test technique, test conditions (including supersonic flow), and test objectives. Particular emphasis is placed on satisfying the various similitude requirements for incompressible and compressible flow conditions. For free flying models tests, the test velocities for incompressible flow are scaled from Froude number similitude requirements and those for compressible flow are scaled from Mach number similitude requirements. The limitations of various test techniques are indicated, with emphasis on the free flying model

    Analysis of the Strong Coupling Limit of the Richardson Hamiltonian using the Dyson Mapping

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    The Richardson Hamiltonian describes superconducting correlations in a metallic nanograin. We do a perturbative analysis of this and related Hamiltonians, around the strong pairing limit, without having to invoke Bethe Ansatz solvability. Rather we make use of a boson expansion method known as the Dyson mapping. Thus we uncover a selection rule that facilitates both time-independent and time-dependent perturbation expansions. In principle the model we analise is realised in a very small metalic grain of a very regular shape. The results we obtain point to subtleties sometimes neglected when thinking of the superconducting state as a Bose-Einstein condensate. An appendix contains a general presentation of time-independent perturbation theory for operators with degenerate spectra, with recursive formulas for corrections of arbitrarily high orders.Comment: New final version accepted for publication in PRB. 17 two-column pages, no figure

    Branching of the Falkner-Skan solutions for λ < 0

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    The Falkner-Skan equation f'" + ff" + λ(1 - f'^2) = 0, f(0) = f'(0) = 0, is discussed for λ < 0. Two types of problems, one with f'(∞) = 1 and another with f'(∞) = -1, are considered. For λ = 0- a close relation between these two types is found. For λ < -1 both types of problem allow multiple solutions which may be distinguished by an integer N denoting the number of zeros of f' - 1. The numerical results indicate that the solution branches with f'(∞) = 1 and those with f'(∞) = -1 tend towards a common limit curve as N increases indefinitely. Finally a periodic solution, existing for λ < -1, is presented.

    Field Quantization, Photons and Non-Hermitean Modes

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    Field quantization in three dimensional unstable optical systems is treated by expanding the vector potential in terms of non-Hermitean (Fox-Li) modes in both the cavity and external regions. The cavity non-Hermitean modes (NHM) are treated using the paraxial and monochromaticity approximations. The NHM bi-orthogonality relationships are used in a standard canonical quantization procedure based on introducing generalised coordinates and momenta for the electromagnetic (EM) field. The quantum EM field is equivalent to a set of quantum harmonic oscillators (QHO), associated with either the cavity or the external region NHM. This confirms the validity of the photon model in unstable optical systems, though the annihilation and creation operators for each QHO are not Hermitean adjoints. The quantum Hamiltonian for the EM field is the sum of non-commuting cavity and external region contributions, each of which is sum of independent QHO Hamiltonians for each NHM, but the external field Hamiltonian also includes a coupling term responsible for external NHM photon exchange processes. Cavity energy gain and loss processes is associated with the non-commutativity of cavity and external region operators, given in terms of surface integrals involving cavity and external region NHM functions on the cavity-external region boundary. The spontaneous decay of a two-level atom inside an unstable cavity is treated using the essential states approach and the rotating wave approximation. Atomic transitions leading to cavity NHM photon absorption have a different coupling constant to those leading to photon emission, a feature resulting from the use of NHM functions. Under certain conditions the decay rate is enhanced by the Petermann factor.Comment: 38 pages, tex, 2 figures, ps. General expression for decay rate added. To be published in Journal of Modern Optic
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