Factors Affecting Participation in Cervical Cancer Screening Programs

It has been asserted elsewhere that widespread use of cytologic screening can prevent mortality from cancer of the uterine cervix. The truth of this assertion depends upon three main factors: on the probability that cases of invasive cervical cancer are preceded by an earlier, less malignant stage (called carcinoma in situ); on the probability that the screening test (the Pap smear) can detect cases of carcinoma in situ; and on the probability that a woman will be screened, and screened repeatedly, for this disease. This paper examines the third factor. We ask what factors influence whether and how often a woman will be screened. After having determined these factors, we can suggest how they should affect the efficient design of a screening program

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity. A candidate gene study was conducted to assess potential association of genetic variants with GI toxicity in 808 patients who received carboplatin/taxane in the Scottish Randomized Trial in Ovarian Cancer 1 (SCOTROC1). Patients were randomized into discovery and validation cohorts consisting of 404 patients each. Clinical covariates and genetic variants associated with grade III/IV GI toxicity in discovery cohort were evaluated in replication cohort. Chemotherapy-induced GI toxicity was significantly associated with seven single-nucleotide polymorphisms in the ATP7B, GSR, VEGFA and SCN10A genes. Patients with risk genotypes were at 1.53 to 18.01 higher odds to develop carboplatin/taxane-induced GI toxicity (P<0.01). Variants in the VEGF gene were marginally associated with survival time. Our data provide potential targets for modulation/inhibition of GI toxicity in ovarian cancer patients

Prediction of Microstructure in Laser Deposition of Titanium Alloys

Laser deposition of titanium alloys is under consideration for aerospace applications, and offers significant increases in efficiency and flexibility compared to conventional manufacturing methods. However, its ultimate success will depend on the ability to predict and control the microstructure and resulting mechanical properties of the deposit. In this study, both 2-D continuum finite element modeling and 3-D cellular automaton finite element modeling of a thinwall geometry are used to investigate the effects of deposition process variables on microstructure in laser deposited Ti-6Al-4V. Numerical results for cooling rate and thermal gradient obtained from the 2-D models are used to provide insight into grain size and morphology, while the 3-D cellular automaton models are used to provide direct predictions of deposited microstructure. The numerical model predictions are subsequently compared with observed microstructures in LENSTM deposited Ti-6Al-4V.This work was supported by the Joint AFRL/DAGSI Research Program, project number ML-WSU-01-11, as well as by a grant from Wright State University and the Ohio Board of Regents.Mechanical Engineerin

The size of Selmer groups for the congruent number problem, II

The oldest problem in the theory of elliptic curves is to determine which positive integers D can be the common difference of a three term arithmetic progres-sion of squares of rational numbers. Such integers D are known as congruent numbers. Equivalently one may ask which elliptic curve

Enhanced enforcement of the foreign corrupt practices act: Improving the ethics of U.S. business practices abroad

Empirical research demonstrates that bribery has a detrimental impact on investment, economic growth, trade, and democratic governments. In response to rising bribery activity and the additional burdens placed on corporate officials by the Sarbanes-Oxley Act of 2002, enforcement of the Foreign Corrupt Practices Act (FCPA) of 1977 has reached an all-time high. Although many managers, financial officers, entrepreneurs, and auditors are aware of the FCPA\u27s objectives and mandates, many do not do an adequate job of protecting their firms, employees, and/or clients from fines and prison sentences. The purposes of this paper are to (1) analyze and describe bribery and FCPA case filings, sanctions, payments (bribes), and value of business to be obtained; (2) describe and analyze the important provisions of the FCPA; (3) discuss vicarious liability or the liability of U.S. firms and others for the acts of third parties; and (4) make recommendations to help firms improve their compliance with the FCPA. © 2012 by Emerald Group Publishing Limited

On some problems involving Hardy's function

Some problems involving the classical Hardy function $$Z(t) := \zeta(1/2+it)\bigl(\chi(1/2+it)\bigr)^{-1/2}, \quad \zeta(s) = \chi(s)\zeta(1-s)$$ are discussed. In particular we discuss the odd moments of $Z(t)$, the distribution of its positive and negative values and the primitive of $Z(t)$. Some analogous problems for the mean square of $|\zeta(1/2+it)|$ are also discussed.Comment: 15 page

Improved model identification for non-linear systems using a random subsampling and multifold modelling (RSMM) approach

In non-linear system identification, the available observed data are conventionally partitioned into two parts: the training data that are used for model identification and the test data that are used for model performance testing. This sort of 'hold-out' or 'split-sample' data partitioning method is convenient and the associated model identification procedure is in general easy to implement. The resultant model obtained from such a once-partitioned single training dataset, however, may occasionally lack robustness and generalisation to represent future unseen data, because the performance of the identified model may be highly dependent on how the data partition is made. To overcome the drawback of the hold-out data partitioning method, this study presents a new random subsampling and multifold modelling (RSMM) approach to produce less biased or preferably unbiased models. The basic idea and the associated procedure are as follows. First, generate K training datasets (and also K validation datasets), using a K-fold random subsampling method. Secondly, detect significant model terms and identify a common model structure that fits all the K datasets using a new proposed common model selection approach, called the multiple orthogonal search algorithm. Finally, estimate and refine the model parameters for the identified common-structured model using a multifold parameter estimation method. The proposed method can produce robust models with better generalisation performance

'The natural foundation of perfect efficiency' : medical services and the Victorian Post Office

This article explores the creation of the Post Office medical service. Working for the Post Office was relatively well-paid and an increasing number of doctors were employed. Medical provision expanded with the introduction of non-contributory pensions from mid-century and developed into a comprehensive and nationwide service that was involved at all stages of employment, from initial recruitment through to receiving a pension. Post Office doctors assessed candidates’ fitness for work, checked on sick absences, provided free medicine and advice and visited workers’ homes. Doctors were responsible for determining whether or not a worker should be pensioned off on grounds of ill health. The career of the first Chief Medical Officer, Dr Waller Lewis, also illustrates the range of other areas in which the Post Office medical service became involved, including the clinical assessment and relief of sickness as well as identifying preventative measures to improve health outcomes.Kingston Universit