A Study of How Children Can Be Taught to Think Better

This study was concerned with ways to improve the thinking of upper elementary school children. An attempt was made to analyze classroom situations which do and do not help children learn to think, and to make suggestions for developing skills in thinking. Criteria were developed by the writer and were presented to upper elementary classroom teachers to help them evaluate themselves in teaching children to think. This problem was the study of how classroom teachers can teach children to think better. If the democratic way of life in the United States is to survive and the world tomorrow is to be a good place in which to live; then the schools must assume the responsibility of educating boys and girls so that they will have the ability to solve the ever-changing problems of the present and future. Although teaching children to think has long been one of the major objectives of education, it is ...comparatively new for schools to seek ways whereby they may effectively and directly teach pupils to think. The writer feels that teaching children to think better at all maturity levels is the best assurance teachers can give children for solving present and future problems. Before teachers can teach children to think, they must know what skills in thinking can be taught and how they can be taught. Therefore, it was the purpose of this study to bring together available facts and opinions from widely scattered sources to help classroom teachers evaluate their teaching procedures in relation to what has been done to teach children to think and to make suggestions to stimulate action in improving instruction in thinking

Characterization of the interaction between Basigin and the pattern recognition receptor TLR4

Toll-like receptors (TLRs) are a major group of pattern recognition receptors expressed on the surface of immune cells that recognize molecular patterns associated with all classes of pathogenic microorganisms. TLR4 recognizes the lipopolysaccharide component of Gram-negative bacterial cell walls and is the only TLR known to induce signaling through both the MyD88 and TRIF pathways. Basigin, a ubiquitous cell adhesion molecule, is a member of the immunoglobulin superfamily that has the ability to influence cell signaling mediated by the MyD88 and TRIF pathways, the same signaling pathways induced by the TLR4 receptor protein. Analysis of the Basigin protein sequence indicates the presence of a hydrophilic glutamate residue within the hydrophobic transmembrane domain, but no consensus binding sites for MyD88 or TRIF. The purpose of this study was to determine if Basigin uses TLR4 for signal transduction. It is hypothesized that Basigin interacts with TLR4 and that the glutamate residue plays a role in the interaction. Enzyme-linked immunosorbent binding assays were performed using endogenous TLR4 and recombinant Basigin proteins. These analyses demonstrated that binding of Basigin to TLR4 was significantly greater than that of the control protein and that the glutamate residue in the Basigin transmembrane domain does play a role in the interaction between Basigin and TLR4 as well as many hydrophobic residues in the Basigin transmembrane domain. The data suggest that Basigin interacts with TLR4 to influence signaling cascades using MyD88 and TRIF

Remembrance

I smile, think of you and smile, eyes burning wet, but smile..

Relevant Participants\u27 Participation in Systems Development: When is Particitipation Irrelevant?

User participation and involvement (UPI) are complex concepts with many factors. This complexity stems from the different ways in how users are defined, how they participate and are involved, from the characteristics of the system, and the various phases within systems development. Managing UPI is important to change agents, i.e., managers, information technology experts, and consultants because they are the ones who are tasked with choosing the best participants at the right time to contribute to the systems development process to ensure a successful system. By reviewing relevant literature, this paper examines when participants should not participate in specific phases of systems development so as to not impede success or contribute to the failure of the systems development project

Multiplexed prostate cancer companion diagnostic devices

Prostate cancer (PCa) remains one of the most prominent forms of cancer for men. Since the early 1990s, Prostate-Specific Antigen (PSA) has been a commonly recognized PCa-associated protein biomarker. However, PSA testing has been shown to lack in specificity and sensitivity when needed to diagnose, monitor and/or treat PCa patients successfully. One enhancement could include the simultaneous detection of multiple PCa-associated protein biomarkers alongside PSA, also known as multiplexing. If conventional methods such as the enzyme-linked immunosorbent assay (ELISA) are used, multiplexed detection of such protein biomarkers can result in an increase in the required sample volume, in the complexity of the analytical procedures, and in adding to the cost. Using companion diagnostic devices such as biosensors, which can be portable and cost-effective with multiplexing capacities, may address these limitations. This review explores recent research for multiplexed PCa protein biomarker detection using optical and electrochemical biosensor platforms. Some of the novel and potential serum-based PCa protein biomarkers will be discussed in this review. In addition, this review discusses the importance of converting research protocols into multiplex point-of-care testing (xPOCT) devices to be used in near-patient settings, providing a more personalized approach to PCa patients’ diagnostic, surveillance and treatment management

Using a Bone-Conduction Headset to Improve Speech Discrimination in Children With Otitis Media With Effusion.

The recommended management for children with otitis media with effusion (OME) is 'watchful waiting' before considering grommet surgery. During this time speech and language, listening skills, quality of life, social skills, and outcomes of education can be jeopardized. Air-conduction (AC) hearing aids are problematic due to fluctuating AC hearing loss. Bone-conduction (BC) hearing is stable, but BC hearing aids can be uncomfortable. Both types of hearing aids are costly. Given the high prevalence of OME and the transitory nature of the accompanying hearing loss, cost-effective solutions are needed. The leisure industry has developed relatively inexpensive, comfortable, high-quality BC headsets for transmission of speech or music. This study assessed whether these headsets, paired with a remote microphone, improve speech discrimination for children with OME. Nineteen children aged 3 to 6 years receiving recommended management in the United Kingdom for children with OME participated. Word-discrimination thresholds were measured in a sound-treated room in quiet and with 65 dB(A) speech-shaped noise, with and without a headset. The median threshold in quiet (N = 17) was 39 dB(A) (range: 23-59) without a headset and 23 dB(A) (range: 9-35) with a headset (Z = -3.519, p < .001). The median threshold in noise (N = 19) was 59 dB(A) (range: 50-63) without a headset and 45 dB(A) (range: 32-50) with a headset (Z = -3.825, p < .001). Thus, the use of a BC headset paired with a remote microphone significantly improved speech discrimination in quiet and in noise for children with OME.The main source of funding for this study was the Cambridge Hearing Trust. T. H. B. was awarded the British Association of Paediatricians in Audiology Prize in 2017, and J. E. M. and M. S.-C. were jointly granted the Stuart Gatehouse Applied Research Grant 2015 by the British Society of Audiology, both toward the Bone conduction In Glue ear study

Mental contamination in the "Dirty Kiss": Imaginal betrayal or bodily fluids?

It has been suggested that an act of a betrayal by a trusted person is a particularly important “violation” which can lead to feelings of “mental contamination”. Most experimental research has used an imaginal task referred to as the “dirty kiss” (an imagined scenario of a non-consensual kiss). The theoretical emphasis in these studies has been on the element of betrayal; however, prominent in the imaginal task is that it involves contact and saliva. The aim of the present study was to disentangle these elements. Female participants (n=80) were randomised to one of four conditions involving betrayal and contact/no contact. They imagined themselves as either receiving a non-consensual kiss from a friend or a stranger, or having a valued personal belonging stolen by a friend or a stranger. The betrayal manipulation was effective. Participants who imagined a non-consensual kiss reported the greatest feelings of mental contamination, irrespective of their relationship to the perpetrator. Violations not involving imagined physical contact did not result in feelings of contamination whether or not betrayal was evoked. It is concluded that imagined physical contact but not imagined betrayal is important in evoking feelings of contamination in this procedure. <br/

The State of Digital Media Data Research, 2024

The purpose of this report is to reflect on the state of digital media data research in 2024. This is the second in a series of reports on the state of digital media research, which we originally published in 2023. We reflect on changes to digital media research since our report in 2023. Specifically, we highlight the following trends: 1. From 2023 to 2024, access to digital media data changed drastically. Researchers were largely priced out of the Twitter API, and Pushshift–a commonly used archive for Reddit data–went private to comply with Reddit’s API policies. Meta also announced the imminent sunsetting of CrowdTangle, a transparency tool popular amongst researchers and journalists alike. At the same time, however, many platforms announced academic programs for data access, including the YouTube researcher program, TikTok’s Research API, and the Meta Content Library. 2. Federated social media platforms became more popular. Following Elon Musk’s purchase of Twitter, Twitter users flocked to Mastodon, Threads, BlueSky, and other federated (or soon to be federated) platforms. This presents unique challenges for researchers studying digital media data. As new platforms are created, researchers must build new tools to analyze them or wait for third parties or the platforms themselves to make data available. 3. Generative AI’s explosion may change how we study digital media. First, researchers using computational methods to measure social media content have turned to OpenAI’s ChatGPT and other Large Language Models (LLMs) to classify content. Second, researchers and civil society groups are increasingly concerned about the possibility for Generative AI to flood the information environment with fake content. 4. In February 2024, the EU Digital Services Act (DSA) went into effect, mandating that large platforms give researchers near real-time access to public data. We don’t yet know how these policies will impact data access in the United States, and it remains unclear what this data access will look like in practice. In the United States, legislative efforts to mandate researcher access stalled. While the last year brought many welcome and unwelcome changes to digital media data research, the findings in this report renew our encouragement that digital media data research should be guided by collaboration, transparency, preparation, and consistency.Journalism and Medi

Improving weekend handover in a teaching hospital elective general surgery department

BackgroundEffective documentation and transfer of clinical information are vital for the continuity of care, patient safety, and maintaining medico-legal records, as outlined by the Royal College of Surgeons “Safe Handover: Guidance from the Working Time Directive working party”. Our elective surgery weekend team cross-covers both Colorectal and Upper Gastrointestinal surgical specialties across multiple wards, which poses a significant challenge. The aim of this study was to improve the documentation of patients' weekend plans through the introduction of a weekend handover proforma.MethodWe reviewed the weekend plans of 199 patients overall. 41 records were initially reviewed over a 2-week period. The surgical multidisciplinary team was then surveyed to establish the need for an improved weekend handover. Following this, a weekend handover proforma was introduced as part of the Friday ward round and education on the expectations were provided at a local Surgery Clinical Governance meeting. The documentation of the weekend plan was reviewed for 158 patients over a 6-week period and a post-intervention survey was disseminated.ResultsThe preliminary survey highlighted concerns for delayed discharges and patient safety over the weekend, with 88.2% of respondents agreeing a weekend handover proforma would be beneficial. The initial data confirmed inadequate documentation of diagnosis (19.5%), operation/procedure (28.1%), and weekend plans for blood tests (19.5%), discharge planning (2.4%), diet (46.3%), antibiotics (19.5%), intravenous (IV) fluids (22.0%), mobility (19.5%) and drain/wound care (37.5%). After education and implementing a weekend handover proforma, these results increased for documentation of diagnosis (61.2%), operation/procedure (83.2%), blood tests (59.7%), and discharge planning (85.8%). However, there was little improvement in diet (53.0%) and no improvement in the weekend plans for antibiotics (14.2%), IV fluids (17.2%), mobility (14.9%) and drain/wound care (20.2%). The post-intervention survey showed an improvement across all areas, notably continuity of care and patient safety, with 95.5% of individuals finding the weekend handover proforma aided in patient care over the weekend.ConclusionEducation of the ward team and implementation of a weekend handover proforma resulted in a marked improvement in the documentation of patients' weekend plans, which is essential to ensure the continuation of safe and effective patient care